Reviewed,
UniProtKB/Swiss-Prot O32271 (TUAD_BACSU)
Last modified
June 16, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UDP-glucose 6-dehydrogenase Short name=UDP-Glc dehydrogenase Short name=UDP-GlcDH Short name=UDPGDH EC=1.1.1.22 Alternative name(s): Teichuronic acid biosynthesis protein tuaD | ||||||
| Gene names |
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| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1423 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 461 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid. |
| Catalytic activity | UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH. |
| Enzyme regulation | Activated by phosphorylation; inhibited by dephosphorylation. Ref.4 |
| Pathway | |
| Subcellular location | |
| Induction | By phosphate starvation, via the phoP/phoR two-component regulatory system. |
| Post-translational modification | Phosphorylated by ywqD and dephosphorylated by ywqE in vitro. Ref.4 |
| Miscellaneous | The nature of the anionic polymer present in the cell wall of B.subtilis depends on phosphate availability. Under phosphate-replete growth conditions teichoic acids are present, whereas under phosphate-depleted conditions, at least part of the wall teichoic acid is replaced with teichuronic acid, a non-phosphate containing anionic polymer. The synthesis of teichuronic acid is accompanied by degradation of teichoic acid and reutilization of liberated phosphate for other cellular processes such as nucleic acid synthesis. |
| Sequence similarities | Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell wall biogenesis/degradation Stress response |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW response to stressInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | NAD or NADH binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Teichuronic acid operon of Bacillus subtilis 168." Soldo B., Lazarevic V., Pagni M., Karamata D. Mol. Microbiol. 31:795-805(1999) [PubMed: 10048024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "Assay for UDPglucose 6-dehydrogenase in phosphate-starved cells: gene tuaD of Bacillus subtilis 168 encodes the UDPglucose 6-dehydrogenase involved in teichuronic acid synthesis." Pagni M., Lazarevic V., Soldo B., Karamata D. Microbiology 145:1049-1053(1999) [PubMed: 10376820] [Abstract] Cited for: CHARACTERIZATION. Strain: 168. |
| [4] | "Transmembrane modulator-dependent bacterial tyrosine kinase activates UDP-glucose dehydrogenases." Mijakovic I., Poncet S., Boel G., Maze A., Gillet S., Jamet E., Decottignies P., Grangeasse C., Doublet P., Le Marechal P., Deutscher J. EMBO J. 22:4709-4718(2003) [PubMed: 12970183] [Abstract] Cited for: PHOSPHORYLATION, ENZYME REGULATION. |
Cross-references
Sequence databases | |
|---|---|
| AF015609 Genomic DNA. Translation: AAB94865.1. AL009126 Genomic DNA. Translation: CAB15575.1. | |
| PIR | F69727. |
| RefSeq | NP_391438.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MFZ based on UniProtKB P11759. |
| ModBase | Search... |
PTM databases | |
| PhosSite | O32271. |
Genome annotation databases | |
| GeneID | 936766. |
| GenomeReviews | Gene locus BSU35580 in contig AL009126_GR. |
| KEGG | bsu:BSU35580. |
| NMPDR | fig|224308.1.peg.3564. |
Organism-specific databases | |
| SubtiList | BG12691. tuaD. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | O32271. |
| OMA | O32271. CLADVGH. |
Enzyme and pathway databases | |
| BioCyc | BSUB224308:BSU3555-MON. |
| BRENDA | 1.1.1.22. 150. |
Family and domain databases | |
| InterPro | IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DH_C. IPR014026. UDP-Glc/GDP-Man_DH_dimer. IPR014028. UDP-Glc/GDP-Man_DH_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DH_N. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit. |
| PANTHER | PTHR11374. UDPG_MGDP_DH_Creg. 1 hit. |
| Pfam | PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03026. NDP-sugDHase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | TUAD_BACSU | ||||||||
| Accession | Primary (citable) accession number: O32271 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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