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Protein

Glycine betaine/carnitine/choline-binding protein OpuCC

Gene

opuCC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of a high affinity multicomponent binding-protein-dependent transport system for glycine betaine, carnitine, and choline.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU33810-MONOMER.
BRENDAi3.6.3.32. 658.

Protein family/group databases

TCDBi3.A.1.12.4. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine betaine/carnitine/choline-binding protein OpuCC
Alternative name(s):
Osmoprotectant-binding protein
Gene namesi
Name:opuCC
Synonyms:yvbC
Ordered Locus Names:BSU33810
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Cell membrane PROSITE-ProRule annotation1 Publication; Lipid-anchor PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20PROSITE-ProRule annotationAdd BLAST20
ChainiPRO_000003184621 – 303Glycine betaine/carnitine/choline-binding protein OpuCCAdd BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi21N-palmitoyl cysteineCurated1
Lipidationi21S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiO32243.

Expressioni

Inductioni

Repressed by OpcR.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (OpuCA), two transmembrane proteins (OpuCB and OpuCD) and a solute-binding protein (OpuCC).1 Publication

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018341.

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 41Combined sources8
Helixi42 – 58Combined sources17
Beta strandi63 – 69Combined sources7
Helixi72 – 80Combined sources9
Beta strandi85 – 91Combined sources7
Helixi92 – 97Combined sources6
Turni98 – 100Combined sources3
Helixi108 – 123Combined sources16
Beta strandi125 – 127Combined sources3
Beta strandi137 – 142Combined sources6
Helixi143 – 149Combined sources7
Beta strandi152 – 154Combined sources3
Helixi155 – 163Combined sources9
Beta strandi165 – 168Combined sources4
Helixi172 – 174Combined sources3
Beta strandi176 – 179Combined sources4
Helixi180 – 187Combined sources8
Beta strandi192 – 196Combined sources5
Helixi199 – 201Combined sources3
Helixi202 – 207Combined sources6
Beta strandi210 – 217Combined sources8
Helixi222 – 225Combined sources4
Beta strandi228 – 230Combined sources3
Beta strandi242 – 248Combined sources7
Helixi249 – 254Combined sources6
Helixi258 – 263Combined sources6
Turni264 – 267Combined sources4
Helixi271 – 282Combined sources12
Helixi288 – 298Combined sources11
Helixi300 – 302Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PPNX-ray2.30A/B1-303[»]
3PPOX-ray2.70A/B1-303[»]
3PPPX-ray2.40A/B1-303[»]
3PPQX-ray1.91A/B1-303[»]
3PPRX-ray2.10A/B1-303[»]
ProteinModelPortaliO32243.
SMRiO32243.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO32243.

Family & Domainsi

Sequence similaritiesi

Belongs to the OsmX family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108HQR. Bacteria.
COG1732. LUCA.
HOGENOMiHOG000015716.
InParanoidiO32243.
KOiK05845.
OMAiIGQIDTE.
PhylomeDBiO32243.

Family and domain databases

InterProiIPR007210. ABC_Gly_betaine_transp_sub-bd.
[Graphical view]
PfamiPF04069. OpuAC. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O32243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKIKWLGAF ALVFVMLLGG CSLPGLGGAS DDTIKIGAQS MTESEIVANM
60 70 80 90 100
IAQLIEHDTD LNTALVKNLG SNYVQHQAML GGDIDISATR YSGTDLTSTL
110 120 130 140 150
GKEAEKDPKK ALNIVQNEFQ KRFSYKWFDS YGFDNTYAFT VTKKFAEKEH
160 170 180 190 200
INTVSDLKKN ASQYKLGVDN AWLKRKGDGY KGFVSTYGFE FGTTYPMQIG
210 220 230 240 250
LVYDAVKNGK MDAVLAYSTD GRIKAYDLKI LKDDKRFFPP YDCSPVIPEK
260 270 280 290 300
VLKEHPELEG VINKLIGQID TETMQELNYE VDGKLKEPSV VAKEFLEKHH

YFD
Length:303
Mass (Da):33,957
Last modified:January 1, 1998 - v1
Checksum:iBEA28D72D7C7E2F9
GO

Sequence cautioni

The sequence AAB63770 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53 – 54QL → HV in AAB63770 (PubMed:10216873).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009352 Genomic DNA. Translation: AAB63770.1. Different initiation.
AL009126 Genomic DNA. Translation: CAB15386.1.
PIRiE69670.
RefSeqiNP_391261.1. NC_000964.3.
WP_003228350.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15386; CAB15386; BSU33810.
GeneIDi936248.
KEGGibsu:BSU33810.
PATRICi18978762. VBIBacSub10457_3544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009352 Genomic DNA. Translation: AAB63770.1. Different initiation.
AL009126 Genomic DNA. Translation: CAB15386.1.
PIRiE69670.
RefSeqiNP_391261.1. NC_000964.3.
WP_003228350.1. NC_000964.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PPNX-ray2.30A/B1-303[»]
3PPOX-ray2.70A/B1-303[»]
3PPPX-ray2.40A/B1-303[»]
3PPQX-ray1.91A/B1-303[»]
3PPRX-ray2.10A/B1-303[»]
ProteinModelPortaliO32243.
SMRiO32243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018341.

Protein family/group databases

TCDBi3.A.1.12.4. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiO32243.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15386; CAB15386; BSU33810.
GeneIDi936248.
KEGGibsu:BSU33810.
PATRICi18978762. VBIBacSub10457_3544.

Phylogenomic databases

eggNOGiENOG4108HQR. Bacteria.
COG1732. LUCA.
HOGENOMiHOG000015716.
InParanoidiO32243.
KOiK05845.
OMAiIGQIDTE.
PhylomeDBiO32243.

Enzyme and pathway databases

BioCyciBSUB:BSU33810-MONOMER.
BRENDAi3.6.3.32. 658.

Miscellaneous databases

EvolutionaryTraceiO32243.

Family and domain databases

InterProiIPR007210. ABC_Gly_betaine_transp_sub-bd.
[Graphical view]
PfamiPF04069. OpuAC. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPUCC_BACSU
AccessioniPrimary (citable) accession number: O32243
Secondary accession number(s): O31407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.