O32242 (SDPR_BACSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcriptional repressor SdpR

Gene names

Name:	sdpR
Synonyms:	yvbA
Ordered Locus Names:	BSU33790

Organism

Bacillus subtilis (strain 168) [Reference proteome] [HAMAP]

Taxonomic identifier

224308 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus subtilis group › Bacillus subtilis › Bacillus subtilis subsp. subtilis

Protein attributes

Sequence length	90 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. Ref.2
Subcellular location	Cytoplasm. Note: Sequestred at the bacterial membrane by SdpC-bound SdpI. Ref.2
Induction	By Spo0A during nutrient starvation. Repressed by AbrB during regular growth when nutrients are plentiful. Represses its own transcription. Ref.2
Sequence similarities	Contains 1 HTH arsR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 90	90	Transcriptional repressor SdpR		PRO_0000312745
Regions
	Domain	1 – 87	87	HTH arsR-type
	DNA binding	39 – 62	24	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	O32242 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: E2008BDD17975113	FASTA	90	10,243
	10 20 30 40 50 60 MNNVFKAISD PTRRKILDLL KGGDMTAGDI AEHFNISKPS ISHHLNILKQ AEVISDHRKG 70 80 90 QFIYYSLNTT VLQDSINWML NFINKGDNDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[2]	"A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin." Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R. Cell 124:549-559(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION. Strain: 168 / PY79.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL009126 Genomic DNA. Translation: CAB15384.1.
PIR	D70029.
RefSeq	NP_391259.1. NC_000964.3.
3D structure databases
ProteinModelPortal	O32242.
SMR	O32242. Positions 2-68.
ModBase	Search...
Protein-protein interaction databases
STRING	224308.BSU33790.
Proteomic databases
PaxDb	O32242.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB15384; CAB15384; BSU33790.
GeneID	936249.
KEGG	bsu:BSU33790.
PATRIC	18978758. VBIBacSub10457_3542.
Organism-specific databases
GenoList	BSU33790. [Micado]
Phylogenomic databases
eggNOG	COG0640.
HOGENOM	HOG000144508.
OMA	LMMEIFK.
Enzyme and pathway databases
BioCyc	BSUB:BSU33790-MONOMER.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001845. HTH_ArsR_DNA-bd_dom. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF01022. HTH_5. 1 hit. [Graphical view]
PRINTS	PR00778. HTHARSR.
SMART	SM00418. HTH_ARSR. 1 hit. [Graphical view]
PROSITE	PS00846. HTH_ARSR_1. False negative. PS50987. HTH_ARSR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SDPR_BACSU

Accession

Primary (citable) accession number: O32242

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program