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O32241

- SDPI_BACSU

UniProt

O32241 - SDPI_BACSU

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Protein

Immunity protein SdpI

Gene
sdpI, yvaZ, BSU33780
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Immunity protein that provides protection for the cell against the toxic effects of its own SdpC killing factor, and that functions as a receptor/signal transduction protein as well. Once SdpC accumulates in the extracellular milieu, SdpI binds to SdpC, causing sequestration of SdpR at the bacterial membrane.1 Publication

Enzyme and pathway databases

BioCyciBSUB:BSU33780-MONOMER.

Protein family/group databases

TCDBi9.A.32.1.1. the sdpc (peptide-antibiotic killer factor) immunity protein, sdpi (sdpi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunity protein SdpI
Gene namesi
Name:sdpI
Synonyms:yvaZ
Ordered Locus Names:BSU33780
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU33780. [Micado]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Reviewed predictionAdd
BLAST
Transmembranei47 – 6721Helical; Reviewed predictionAdd
BLAST
Transmembranei78 – 9821Helical; Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Reviewed predictionAdd
BLAST
Transmembranei150 – 17021Helical; Reviewed predictionAdd
BLAST
Transmembranei171 – 19121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi6 – 61I → T: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. 1 Publication
Mutagenesisi50 – 501I → T: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. 1 Publication
Mutagenesisi78 – 781F → I: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. 1 Publication
Mutagenesisi84 – 841M → T: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. 1 Publication
Mutagenesisi85 – 851L → S: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. 1 Publication
Mutagenesisi98 – 981I → K: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. 1 Publication
Mutagenesisi126 – 1261Q → L: Loss of ability to promote transcription of the sdpRI genes in response to SdpC binding. No effect in ability to confer immunity to SdpC. 1 Publication
Mutagenesisi156 – 1561S → T: Loss of ability to promote transcription of the sdpRI genes in response to SdpC binding. No effect in ability to confer immunity to SdpC. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Immunity protein SdpIPRO_0000312744Add
BLAST

Proteomic databases

PaxDbiO32241.

Expressioni

Inductioni

By Spo0A during nutrient starvation, through its direct negative control of AbrB. Repressed by AbrB during regular growth when nutrients are plentiful, and also by SdpR.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU33780.

Structurei

3D structure databases

ProteinModelPortaliO32241.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5658.
OMAiVVWRKTH.
OrthoDBiEOG63NMH6.

Family and domain databases

InterProiIPR012867. DUF1648.
IPR026272. SdpI.
IPR025962. SdpI/YhfL.
[Graphical view]
PfamiPF07853. DUF1648. 1 hit.
PF13630. SdpI. 1 hit.
[Graphical view]
PIRSFiPIRSF038959. SdpI. 1 hit.

Sequencei

Sequence statusi: Complete.

O32241-1 [UniParc]FASTAAdd to Basket

« Hide

MKKNIISIII VCLSFLTSII LYQYLPEEIP IQWSGNKPAA IVSKPLTIFI    50
IPVVMLIYYL TFYMLTIKST QKNKALLFLA SNNMLILLYI LQLSTLLISL 100
GYEVNIDLII GLGVGIFLII GGNSMQLAEQ NHLIGLRTPW TLKDETVWKL 150
GNRFASKVLV VCGFIIAVLS FFTGEYIILI MIVLVLLALV ISTLASYHYY 200
KKLNGSR 207
Length:207
Mass (Da):23,293
Last modified:January 1, 1998 - v1
Checksum:i27171B056BA86490
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB15383.1.
PIRiC70029.
RefSeqiNP_391258.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15383; CAB15383; BSU33780.
GeneIDi936238.
KEGGibsu:BSU33780.
PATRICi18978756. VBIBacSub10457_3541.

Cross-referencesi

Web resourcesi

Protein Spotlight

I'll have you for supper - Issue 90 of January 2008

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB15383.1 .
PIRi C70029.
RefSeqi NP_391258.1. NC_000964.3.

3D structure databases

ProteinModelPortali O32241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU33780.

Protein family/group databases

TCDBi 9.A.32.1.1. the sdpc (peptide-antibiotic killer factor) immunity protein, sdpi (sdpi) family.

Proteomic databases

PaxDbi O32241.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15383 ; CAB15383 ; BSU33780 .
GeneIDi 936238.
KEGGi bsu:BSU33780.
PATRICi 18978756. VBIBacSub10457_3541.

Organism-specific databases

GenoListi BSU33780. [Micado ]

Phylogenomic databases

eggNOGi COG5658.
OMAi VVWRKTH.
OrthoDBi EOG63NMH6.

Enzyme and pathway databases

BioCyci BSUB:BSU33780-MONOMER.

Family and domain databases

InterProi IPR012867. DUF1648.
IPR026272. SdpI.
IPR025962. SdpI/YhfL.
[Graphical view ]
Pfami PF07853. DUF1648. 1 hit.
PF13630. SdpI. 1 hit.
[Graphical view ]
PIRSFi PIRSF038959. SdpI. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  2. "A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin."
    Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R.
    Cell 124:549-559(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, MUTAGENESIS OF ILE-6; ILE-50; PHE-78; MET-84; LEU-85; ILE-98; GLN-126 AND SER-156.
    Strain: 168 / PY79.

Entry informationi

Entry nameiSDPI_BACSU
AccessioniPrimary (citable) accession number: O32241
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

External Data

Dasty 3

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