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O32241 (SDPI_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunity protein SdpI
Gene names
Name:sdpI
Synonyms:yvaZ
Ordered Locus Names:BSU33780
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Immunity protein that provides protection for the cell against the toxic effects of its own SdpC killing factor, and that functions as a receptor/signal transduction protein as well. Once SdpC accumulates in the extracellular milieu, SdpI binds to SdpC, causing sequestration of SdpR at the bacterial membrane. Ref.2

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Induction

By Spo0A during nutrient starvation, through its direct negative control of AbrB. Repressed by AbrB during regular growth when nutrients are plentiful, and also by SdpR. Ref.2

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Immunity protein SdpI
PRO_0000312744

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane47 – 6721Helical; Potential
Transmembrane78 – 9821Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane171 – 19121Helical; Potential

Experimental info

Mutagenesis61I → T: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. Ref.2
Mutagenesis501I → T: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. Ref.2
Mutagenesis781F → I: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. Ref.2
Mutagenesis841M → T: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. Ref.2
Mutagenesis851L → S: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. Ref.2
Mutagenesis981I → K: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. Ref.2
Mutagenesis1261Q → L: Loss of ability to promote transcription of the sdpRI genes in response to SdpC binding. No effect in ability to confer immunity to SdpC. Ref.2
Mutagenesis1561S → T: Loss of ability to promote transcription of the sdpRI genes in response to SdpC binding. No effect in ability to confer immunity to SdpC. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O32241 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 27171B056BA86490

FASTA20723,293
        10         20         30         40         50         60 
MKKNIISIII VCLSFLTSII LYQYLPEEIP IQWSGNKPAA IVSKPLTIFI IPVVMLIYYL 

        70         80         90        100        110        120 
TFYMLTIKST QKNKALLFLA SNNMLILLYI LQLSTLLISL GYEVNIDLII GLGVGIFLII 

       130        140        150        160        170        180 
GGNSMQLAEQ NHLIGLRTPW TLKDETVWKL GNRFASKVLV VCGFIIAVLS FFTGEYIILI 

       190        200 
MIVLVLLALV ISTLASYHYY KKLNGSR 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[2]"A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin."
Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R.
Cell 124:549-559(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION, MUTAGENESIS OF ILE-6; ILE-50; PHE-78; MET-84; LEU-85; ILE-98; GLN-126 AND SER-156.
Strain: 168 / PY79.

Web resources

Protein Spotlight

I'll have you for supper - Issue 90 of January 2008

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL009126 Genomic DNA. Translation: CAB15383.1.
PIRC70029.
RefSeqNP_391258.1. NC_000964.3.

3D structure databases

ProteinModelPortalO32241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU33780.

Protein family/group databases

TCDB9.A.32.1.1. the sdpc (peptide-antibiotic killer factor) immunity protein, sdpi (sdpi) family.

Proteomic databases

PaxDbO32241.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB15383; CAB15383; BSU33780.
GeneID936238.
KEGGbsu:BSU33780.
PATRIC18978756. VBIBacSub10457_3541.

Organism-specific databases

GenoListBSU33780. [Micado]

Phylogenomic databases

eggNOGCOG5658.
OMAVVWRKTH.
OrthoDBEOG63NMH6.

Enzyme and pathway databases

BioCycBSUB:BSU33780-MONOMER.

Family and domain databases

InterProIPR012867. DUF1648.
IPR026272. SdpI.
IPR025962. SdpI/YhfL.
[Graphical view]
PfamPF07853. DUF1648. 1 hit.
PF13630. SdpI. 1 hit.
[Graphical view]
PIRSFPIRSF038959. SdpI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSDPI_BACSU
AccessionPrimary (citable) accession number: O32241
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList