Reviewed,
UniProtKB/Swiss-Prot O32241 (SDPI_BACSU)
Last modified
June 16, 2009.
Version 38.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Immunity protein sdpI | ||||||
| Gene names |
| ||||||
| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1423 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 207 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Immunity protein that provides protection for the cell against the toxic effects of its own sdpC killing factor, and that functions as a receptor/signal transduction protein as well. Once sdpC accumulates in the extracellular milieu, sdpI binds to sdpC, causing sequestration of sdpR at the bacterial membrane. Ref.2 |
| Subcellular location | Membrane; Multi-pass membrane protein Potential. |
| Induction | By spo0A during nutrient starvation, through its direct negative control of abrB. Repressed by abrB during regular growth when nutrients are plentiful, and also by sdpR. Ref.2 |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Transmembrane |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 207 | 207 | Immunity protein sdpI | PRO_0000312744 | |||||
Regions | |||||||||
| Transmembrane | 5 – 25 | 21 | Potential | ||||||
| Transmembrane | 47 – 67 | 21 | Potential | ||||||
| Transmembrane | 78 – 98 | 21 | Potential | ||||||
| Transmembrane | 100 – 120 | 21 | Potential | ||||||
| Transmembrane | 150 – 170 | 21 | Potential | ||||||
| Transmembrane | 171 – 191 | 21 | Potential | ||||||
Experimental info | |||||||||
| Mutagenesis | 6 | 1 | I → T: Ability to bypass the requirement of sdpC binding for expression of the sdpRI genes. Ref.2 | ||||||
| Mutagenesis | 50 | 1 | I → T: Ability to bypass the requirement of sdpC binding for expression of the sdpRI genes. Ref.2 | ||||||
| Mutagenesis | 78 | 1 | F → I: Ability to bypass the requirement of sdpC binding for expression of the sdpRI genes. Ref.2 | ||||||
| Mutagenesis | 84 | 1 | M → T: Ability to bypass the requirement of sdpC binding for expression of the sdpRI genes. Ref.2 | ||||||
| Mutagenesis | 85 | 1 | L → S: Ability to bypass the requirement of sdpC binding for expression of the sdpRI genes. Ref.2 | ||||||
| Mutagenesis | 98 | 1 | I → K: Ability to bypass the requirement of sdpC binding for expression of the sdpRI genes. Ref.2 | ||||||
| Mutagenesis | 126 | 1 | Q → L: Loss of ability to promote transcription of the sdpRI genes in response to sdpC binding. No effect in ability to confer immunity to sdpC. Ref.2 | ||||||
| Mutagenesis | 156 | 1 | S → T: Loss of ability to promote transcription of the sdpRI genes in response to sdpC binding. No effect in ability to confer immunity to sdpC. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.  Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [2] | "A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin." Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R. Cell 124:549-559(2006) [PubMed: 16469701] [Abstract] Cited for: FUNCTION, INDUCTION, MUTAGENESIS OF ILE-6; ILE-50; PHE-78; MET-84; LEU-85; ILE-98; GLN-126 AND SER-156. Strain: 168 / PY79. |
Cross-references
Sequence databases | |
|---|---|
| AL009126 Genomic DNA. Translation: CAB15383.1. | |
| PIR | C70029. |
| RefSeq | NP_391258.1. |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| TCDB | 9.A.32.1.1. SdpC (Peptide-antibiotic killer Factor) immunity protein, SdpI family. |
Genome annotation databases | |
| GeneID | 936238. |
| GenomeReviews | Gene locus BSU33780 in contig AL009126_GR. |
| KEGG | bsu:BSU33780. |
| NMPDR | fig|224308.1.peg.3384. |
Organism-specific databases | |
| SubtiList | BG14077. sdpI. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | O32241. |
| OMA | O32241. WIFTFAI. |
Enzyme and pathway databases | |
| BioCyc | BSUB224308:BSU3375-MON. |
Family and domain databases | |
| InterPro | IPR012867. DUF1648. [Graphical view] |
| Pfam | PF07853. DUF1648. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SDPI_BACSU | ||||||||
| Accession | Primary (citable) accession number: O32241 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
