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O32241

- SDPI_BACSU

UniProt

O32241 - SDPI_BACSU

Protein

Immunity protein SdpI

Gene

sdpI

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Immunity protein that provides protection for the cell against the toxic effects of its own SdpC killing factor, and that functions as a receptor/signal transduction protein as well. Once SdpC accumulates in the extracellular milieu, SdpI binds to SdpC, causing sequestration of SdpR at the bacterial membrane.1 Publication

    Enzyme and pathway databases

    BioCyciBSUB:BSU33780-MONOMER.

    Protein family/group databases

    TCDBi9.A.32.1.1. the sdpc (peptide-antibiotic killer factor) immunity protein, sdpi (sdpi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunity protein SdpI
    Gene namesi
    Name:sdpI
    Synonyms:yvaZ
    Ordered Locus Names:BSU33780
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU33780. [Micado]

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi6 – 61I → T: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. 1 Publication
    Mutagenesisi50 – 501I → T: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. 1 Publication
    Mutagenesisi78 – 781F → I: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. 1 Publication
    Mutagenesisi84 – 841M → T: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. 1 Publication
    Mutagenesisi85 – 851L → S: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. 1 Publication
    Mutagenesisi98 – 981I → K: Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes. 1 Publication
    Mutagenesisi126 – 1261Q → L: Loss of ability to promote transcription of the sdpRI genes in response to SdpC binding. No effect in ability to confer immunity to SdpC. 1 Publication
    Mutagenesisi156 – 1561S → T: Loss of ability to promote transcription of the sdpRI genes in response to SdpC binding. No effect in ability to confer immunity to SdpC. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Immunity protein SdpIPRO_0000312744Add
    BLAST

    Proteomic databases

    PaxDbiO32241.

    Expressioni

    Inductioni

    By Spo0A during nutrient starvation, through its direct negative control of AbrB. Repressed by AbrB during regular growth when nutrients are plentiful, and also by SdpR.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU33780.

    Structurei

    3D structure databases

    ProteinModelPortaliO32241.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5658.
    OMAiVVWRKTH.
    OrthoDBiEOG63NMH6.

    Family and domain databases

    InterProiIPR012867. DUF1648.
    IPR026272. SdpI.
    IPR025962. SdpI/YhfL.
    [Graphical view]
    PfamiPF07853. DUF1648. 1 hit.
    PF13630. SdpI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038959. SdpI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O32241-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKNIISIII VCLSFLTSII LYQYLPEEIP IQWSGNKPAA IVSKPLTIFI    50
    IPVVMLIYYL TFYMLTIKST QKNKALLFLA SNNMLILLYI LQLSTLLISL 100
    GYEVNIDLII GLGVGIFLII GGNSMQLAEQ NHLIGLRTPW TLKDETVWKL 150
    GNRFASKVLV VCGFIIAVLS FFTGEYIILI MIVLVLLALV ISTLASYHYY 200
    KKLNGSR 207
    Length:207
    Mass (Da):23,293
    Last modified:January 1, 1998 - v1
    Checksum:i27171B056BA86490
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB15383.1.
    PIRiC70029.
    RefSeqiNP_391258.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB15383; CAB15383; BSU33780.
    GeneIDi936238.
    KEGGibsu:BSU33780.
    PATRICi18978756. VBIBacSub10457_3541.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    I'll have you for supper - Issue 90 of January 2008

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB15383.1 .
    PIRi C70029.
    RefSeqi NP_391258.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali O32241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU33780.

    Protein family/group databases

    TCDBi 9.A.32.1.1. the sdpc (peptide-antibiotic killer factor) immunity protein, sdpi (sdpi) family.

    Proteomic databases

    PaxDbi O32241.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB15383 ; CAB15383 ; BSU33780 .
    GeneIDi 936238.
    KEGGi bsu:BSU33780.
    PATRICi 18978756. VBIBacSub10457_3541.

    Organism-specific databases

    GenoListi BSU33780. [Micado ]

    Phylogenomic databases

    eggNOGi COG5658.
    OMAi VVWRKTH.
    OrthoDBi EOG63NMH6.

    Enzyme and pathway databases

    BioCyci BSUB:BSU33780-MONOMER.

    Family and domain databases

    InterProi IPR012867. DUF1648.
    IPR026272. SdpI.
    IPR025962. SdpI/YhfL.
    [Graphical view ]
    Pfami PF07853. DUF1648. 1 hit.
    PF13630. SdpI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038959. SdpI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    2. "A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin."
      Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R.
      Cell 124:549-559(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, MUTAGENESIS OF ILE-6; ILE-50; PHE-78; MET-84; LEU-85; ILE-98; GLN-126 AND SER-156.
      Strain: 168 / PY79.

    Entry informationi

    Entry nameiSDPI_BACSU
    AccessioniPrimary (citable) accession number: O32241
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

    External Data

    Dasty 3