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Protein

Transcriptional regulatory protein LiaR

Gene

liaR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. LiaR regulates the transcription of the liaIHGFSR operon.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi167 – 186H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Enzyme and pathway databases

BioCyciBSUB:BSU33080-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein LiaR
Gene namesi
Name:liaR
Synonyms:yvqC
Ordered Locus Names:BSU33080
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000811141 – 211Transcriptional regulatory protein LiaRAdd BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by LiaS.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO32197
PRIDEiO32197

Expressioni

Inductioni

Autoregulated. Induced by antibiotics (vancomycin, bacitracin, nisin and ramoplanin), cationic antimicrobial peptides (human LL-37 and porcine PG-1), Triton X-100 and severe secretion stress.4 Publications

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100017956

Structurei

3D structure databases

ProteinModelPortaliO32197
SMRiO32197
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST117
Domaini143 – 208HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Phylogenomic databases

eggNOGiENOG4105WH1 Bacteria
COG2197 LUCA
HOGENOMiHOG000034813
InParanoidiO32197
KOiK11618
OMAiNVLRKTQ
PhylomeDBiO32197

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
cd00156 REC, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR001789 Sig_transdc_resp-reg_receiver
IPR000792 Tscrpt_reg_LuxR_C
PfamiView protein in Pfam
PF00196 GerE, 1 hit
PF00072 Response_reg, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SM00448 REC, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS00622 HTH_LUXR_1, 1 hit
PS50043 HTH_LUXR_2, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

O32197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRVLLIDDH EMVRMGLAAF LEAQPDIEVI GEASDGSEGV RLAVELSPDV
60 70 80 90 100
ILMDLVMEGM DGIEATKQIC RELSDPKIIV LTSFIDDDKV YPVIEAGALS
110 120 130 140 150
YLLKTSKAAE IADAIRAASK GEPKLESKVA GKVLSRLRHS GENALPHESL
160 170 180 190 200
TKRELEILCL IAEGKTNKEI GEELFITIKT VKTHITNILS KLDVSDRTQA
210
AVYAHRNHLV N
Length:211
Mass (Da):23,125
Last modified:January 1, 1998 - v1
Checksum:iADBA4BAE61E3F5A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223978 Genomic DNA Translation: CAA11745.1
AL009126 Genomic DNA Translation: CAB15298.1
PIRiE70045
RefSeqiNP_391188.1, NC_000964.3
WP_003243201.1, NZ_JNCM01000033.1

Genome annotation databases

EnsemblBacteriaiCAB15298; CAB15298; BSU33080
GeneIDi935957
KEGGibsu:BSU33080
PATRICifig|224308.179.peg.3586

Similar proteinsi

Entry informationi

Entry nameiLIAR_BACSU
AccessioniPrimary (citable) accession number: O32197
Secondary accession number(s): Q7B2J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health