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Protein

Transcriptional regulatory protein LiaR

Gene

liaR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. LiaR regulates the transcription of the liaIHGFSR operon.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi167 – 186H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Enzyme and pathway databases

BioCyciBSUB:BSU33080-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein LiaR
Gene namesi
Name:liaR
Synonyms:yvqC
Ordered Locus Names:BSU33080
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000811141 – 211Transcriptional regulatory protein LiaRAdd BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by LiaS.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO32197.

Expressioni

Inductioni

Autoregulated. Induced by antibiotics (vancomycin, bacitracin, nisin and ramoplanin), cationic antimicrobial peptides (human LL-37 and porcine PG-1), Triton X-100 and severe secretion stress.4 Publications

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100017956.

Structurei

3D structure databases

ProteinModelPortaliO32197.
SMRiO32197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST117
Domaini143 – 208HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Phylogenomic databases

eggNOGiENOG4105WH1. Bacteria.
COG2197. LUCA.
HOGENOMiHOG000034813.
InParanoidiO32197.
KOiK11618.
OMAiNVLRKTQ.
PhylomeDBiO32197.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
cd00156. REC. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
PRINTSiPR00038. HTHLUXR.
SMARTiView protein in SMART
SM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

O32197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRVLLIDDH EMVRMGLAAF LEAQPDIEVI GEASDGSEGV RLAVELSPDV
60 70 80 90 100
ILMDLVMEGM DGIEATKQIC RELSDPKIIV LTSFIDDDKV YPVIEAGALS
110 120 130 140 150
YLLKTSKAAE IADAIRAASK GEPKLESKVA GKVLSRLRHS GENALPHESL
160 170 180 190 200
TKRELEILCL IAEGKTNKEI GEELFITIKT VKTHITNILS KLDVSDRTQA
210
AVYAHRNHLV N
Length:211
Mass (Da):23,125
Last modified:January 1, 1998 - v1
Checksum:iADBA4BAE61E3F5A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223978 Genomic DNA. Translation: CAA11745.1.
AL009126 Genomic DNA. Translation: CAB15298.1.
PIRiE70045.
RefSeqiNP_391188.1. NC_000964.3.
WP_003243201.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15298; CAB15298; BSU33080.
GeneIDi935957.
KEGGibsu:BSU33080.
PATRICifig|224308.179.peg.3586.

Similar proteinsi

Entry informationi

Entry nameiLIAR_BACSU
AccessioniPrimary (citable) accession number: O32197
Secondary accession number(s): Q7B2J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList