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Protein

Methionine import ATP-binding protein MetN

Gene

metN

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex MetNPQ involved in methionine import. Responsible for energy coupling to the transport system (Probable). It has also been shown to be involved in methionine sulfoxide transport.Curated1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU32750-MONOMER.

Protein family/group databases

TCDBi3.A.1.24.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine import ATP-binding protein MetNUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:metNUniRule annotation
Synonyms:yusC
Ordered Locus Names:BSU32750
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Methionine import ATP-binding protein MetNPRO_0000270247Add
BLAST

Proteomic databases

PaxDbiO32169.

Expressioni

Inductioni

Repressed by methionine via the S-box system.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetP) and a solute-binding protein (MetQ).Curated

Protein-protein interaction databases

IntActiO32169. 1 interaction.
MINTiMINT-8366514.
STRINGi224308.Bsubs1_010100017771.

Structurei

3D structure databases

ProteinModelPortaliO32169.
SMRiO32169. Positions 1-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 241240ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JEI. Bacteria.
COG1135. LUCA.
InParanoidiO32169.
KOiK02071.
OMAiAEVITNV.
PhylomeDBiO32169.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR026253. ABC_MetN.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017908. ABC_transprt_methionine_MetN_C.
IPR018449. NIL_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24220:SF186. PTHR24220:SF186. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
PF09383. NIL. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00930. NIL. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51264. METN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O32169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINLQDVSKV YKSKHGDVNA VQNVSLSIKK GEIFGIIGYS GAGKSSLIRL
60 70 80 90 100
LNGLEKPTSG TVEVAGTKIN EVNGRGLRKA RHEISMIFQH FNLLWSRTVR
110 120 130 140 150
DNIMFPLEIA GVKKSERIKR ANELIKLVGL EGKEKSYPSQ LSGGQKQRVG
160 170 180 190 200
IARALANNPK VLLCDEATSA LDPQTTDSIL DLLSDINERL GLTIVLITHE
210 220 230 240 250
MHVIRKICNR VAVMENGKVV EEGEVLDVFK NPKEQMTKRF VQQVTEPEET
260 270 280 290 300
KETLQHLLDD TASGKMVQLT FVGESAEQPL ITEMIRNFNV SVNILQGKIS
310 320 330 340
QTKDGAYGSL FIHIDGDEEE VQNVIRFIND KQVKAEVITN V
Length:341
Mass (Da):37,886
Last modified:January 1, 1998 - v1
Checksum:i37DDC75528723311
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB15264.1.
PIRiD70020.
RefSeqiNP_391154.1. NC_000964.3.
WP_003242531.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15264; CAB15264; BSU32750.
GeneIDi936700.
KEGGibsu:BSU32750.
PATRICi18978530. VBIBacSub10457_3428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB15264.1.
PIRiD70020.
RefSeqiNP_391154.1. NC_000964.3.
WP_003242531.1. NZ_JNCM01000033.1.

3D structure databases

ProteinModelPortaliO32169.
SMRiO32169. Positions 1-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO32169. 1 interaction.
MINTiMINT-8366514.
STRINGi224308.Bsubs1_010100017771.

Protein family/group databases

TCDBi3.A.1.24.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiO32169.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15264; CAB15264; BSU32750.
GeneIDi936700.
KEGGibsu:BSU32750.
PATRICi18978530. VBIBacSub10457_3428.

Phylogenomic databases

eggNOGiENOG4108JEI. Bacteria.
COG1135. LUCA.
InParanoidiO32169.
KOiK02071.
OMAiAEVITNV.
PhylomeDBiO32169.

Enzyme and pathway databases

BioCyciBSUB:BSU32750-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR026253. ABC_MetN.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017908. ABC_transprt_methionine_MetN_C.
IPR018449. NIL_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24220:SF186. PTHR24220:SF186. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
PF09383. NIL. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00930. NIL. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51264. METN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMETN_BACSU
AccessioniPrimary (citable) accession number: O32169
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.