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Protein

Methionine import system permease protein MetP

Gene

metP

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex MetNPQ involved in methionine import. Responsible for the translocation of the substrate across the membrane (Probable). It has also been shown to be involved in methionine sulfoxide transport.Curated1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU32740-MONOMER.

Protein family/group databases

TCDBi3.A.1.24.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine import system permease protein MetP
Gene namesi
Name:metP
Synonyms:yusB
Ordered Locus Names:BSU32740
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei73 – 93HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei97 – 117HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei152 – 172HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei195 – 215HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003836441 – 222Methionine import system permease protein MetPAdd BLAST222

Proteomic databases

PaxDbiO32168.
PRIDEiO32168.

Expressioni

Inductioni

Repressed by methionine via the S-box system.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetP) and a solute-binding protein (MetQ).By similarity

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100017766.

Structurei

3D structure databases

ProteinModelPortaliO32168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 212ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST195

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108UMI. Bacteria.
COG2011. LUCA.
HOGENOMiHOG000222815.
InParanoidiO32168.
KOiK02072.
OMAiMFEKWFP.
PhylomeDBiO32168.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O32168-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEKYFPNVD LTELWNATYE TLYMTLISLL FAFVIGVILG LLLFLTSKGS
60 70 80 90 100
LWQNKAVNSV IAAVVNIFRS IPFLILIILL LGFTKFLVGT ILGPNAALPA
110 120 130 140 150
LVIGSAPFYA RLVEIALREV DKGVIEAAKS MGAKTSTIIF KVLIPESMPA
160 170 180 190 200
LISGITVTAI ALIGSTAIAG AIGSGGLGNL AYVEGYQSNN ADVTFVATVF
210 220
ILIIVFIIQI IGDLITNIID KR
Length:222
Mass (Da):23,756
Last modified:January 1, 1998 - v1
Checksum:i7EA50D635BD2F261
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB15263.1.
PIRiC70020.
RefSeqiNP_391153.1. NC_000964.3.
WP_003228593.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15263; CAB15263; BSU32740.
GeneIDi936709.
KEGGibsu:BSU32740.
PATRICi18978528. VBIBacSub10457_3427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB15263.1.
PIRiC70020.
RefSeqiNP_391153.1. NC_000964.3.
WP_003228593.1. NZ_JNCM01000033.1.

3D structure databases

ProteinModelPortaliO32168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100017766.

Protein family/group databases

TCDBi3.A.1.24.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiO32168.
PRIDEiO32168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15263; CAB15263; BSU32740.
GeneIDi936709.
KEGGibsu:BSU32740.
PATRICi18978528. VBIBacSub10457_3427.

Phylogenomic databases

eggNOGiENOG4108UMI. Bacteria.
COG2011. LUCA.
HOGENOMiHOG000222815.
InParanoidiO32168.
KOiK02072.
OMAiMFEKWFP.
PhylomeDBiO32168.

Enzyme and pathway databases

BioCyciBSUB:BSU32740-MONOMER.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMETP_BACSU
AccessioniPrimary (citable) accession number: O32168
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.