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O32167

- METQ_BACSU

UniProt

O32167 - METQ_BACSU

Protein

Methionine-binding lipoprotein MetQ

Gene

metQ

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Part of the ABC transporter complex MetNPQ involved in methionine import. Binds the methionine and transfers it to the membrane-bound permease. It has also been shown to be involved in methionine sulfoxide transport Probable.Curated

    GO - Biological processi

    1. amino acid transport Source: UniProtKB-KW

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    BioCyciBSUB:BSU32730-MONOMER.

    Protein family/group databases

    TCDBi3.A.1.24.2. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine-binding lipoprotein MetQ
    Gene namesi
    Name:metQ
    Synonyms:yusA
    Ordered Locus Names:BSU32730
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU32730. [Micado]

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919PROSITE-ProRule annotationAdd
    BLAST
    Chaini20 – 274255Methionine-binding lipoprotein MetQPRO_0000383645Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi20 – 201N-palmitoyl cysteinePROSITE-ProRule annotation
    Lipidationi20 – 201S-diacylglycerol cysteinePROSITE-ProRule annotation

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiO32167.

    Expressioni

    Inductioni

    Repressed by methionine via the S-box system.1 Publication

    Interactioni

    Subunit structurei

    The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetP) and a solute-binding protein (metQ).By similarity

    Protein-protein interaction databases

    STRINGi224308.BSU32730.

    Structurei

    Secondary structure

    1
    274
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi32 – 376
    Turni39 – 413
    Helixi42 – 5413
    Turni55 – 573
    Beta strandi59 – 635
    Helixi70 – 767
    Beta strandi81 – 877
    Helixi88 – 9710
    Beta strandi103 – 1119
    Beta strandi115 – 1173
    Helixi124 – 1263
    Beta strandi132 – 1365
    Helixi139 – 1413
    Helixi142 – 15110
    Helixi163 – 1653
    Helixi168 – 1703
    Beta strandi171 – 1733
    Beta strandi179 – 1835
    Turni185 – 1873
    Helixi188 – 1936
    Beta strandi197 – 2026
    Helixi204 – 2096
    Helixi214 – 2174
    Beta strandi219 – 2213
    Beta strandi231 – 2366
    Helixi243 – 25210
    Helixi255 – 26410
    Turni265 – 2673
    Beta strandi268 – 2714

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GOTX-ray1.95A27-274[»]
    ProteinModelPortaliO32167.
    SMRiO32167. Positions 32-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NlpA lipoprotein family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1464.
    HOGENOMiHOG000222927.
    KOiK02073.
    OMAiPKNLEFK.
    OrthoDBiEOG6P073X.
    PhylomeDBiO32167.

    Family and domain databases

    InterProiIPR004872. Lipoprotein_NlpA.
    [Graphical view]
    PfamiPF03180. Lipoprotein_9. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002854. MetQ. 1 hit.
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O32167-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKLFLGALL LVFAGVMAAC GSNNGAESGK KEIVVAATKT PHAEILKEAE    50
    PLLKEKGYTL KVKVLSDYKM YNKALADKEV DANYFQHIPY LEQEMKENTD 100
    YKLVNAGAVH LEPFGIYSKT YKSLKDLPDG ATIILTNNVA EQGRMLAMLE 150
    NAGLITLDSK VETVDATLKD IKKNPKNLEF KKVAPELTAK AYENKEGDAV 200
    FINVNYAIQN KLNPKKDAIE VESTKNNPYA NIIAVRKGEE DSAKIKALME 250
    VLHSKKIKDF IEKKYDGAVL PVSE 274
    Length:274
    Mass (Da):30,355
    Last modified:January 1, 1998 - v1
    Checksum:i3D40F949A1BFC73C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB15262.1.
    PIRiB70020.
    RefSeqiNP_391152.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB15262; CAB15262; BSU32730.
    GeneIDi936716.
    KEGGibsu:BSU32730.
    PATRICi18978526. VBIBacSub10457_3426.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB15262.1 .
    PIRi B70020.
    RefSeqi NP_391152.1. NC_000964.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GOT X-ray 1.95 A 27-274 [» ]
    ProteinModelPortali O32167.
    SMRi O32167. Positions 32-274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU32730.

    Protein family/group databases

    TCDBi 3.A.1.24.2. the atp-binding cassette (abc) superfamily.

    Proteomic databases

    PaxDbi O32167.

    Protocols and materials databases

    DNASUi 936716.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB15262 ; CAB15262 ; BSU32730 .
    GeneIDi 936716.
    KEGGi bsu:BSU32730.
    PATRICi 18978526. VBIBacSub10457_3426.

    Organism-specific databases

    GenoListi BSU32730. [Micado ]

    Phylogenomic databases

    eggNOGi COG1464.
    HOGENOMi HOG000222927.
    KOi K02073.
    OMAi PKNLEFK.
    OrthoDBi EOG6P073X.
    PhylomeDBi O32167.

    Enzyme and pathway databases

    BioCyci BSUB:BSU32730-MONOMER.

    Family and domain databases

    InterProi IPR004872. Lipoprotein_NlpA.
    [Graphical view ]
    Pfami PF03180. Lipoprotein_9. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002854. MetQ. 1 hit.
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    2. "The metNPQ operon of Bacillus subtilis encodes an ABC permease transporting methionine sulfoxide, D- and L-methionine."
      Hullo M.-F., Auger S., Dassa E., Danchin A., Martin-Verstraete I.
      Res. Microbiol. 155:80-86(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROBABLE FUNCTION IN METHIONINE AND METHIONINE SULFOXIDE TRANSPORT, INDUCTION.
      Strain: 168.

    Entry informationi

    Entry nameiMETQ_BACSU
    AccessioniPrimary (citable) accession number: O32167
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3