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Protein

Methionine-binding lipoprotein MetQ

Gene

metQ

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex MetNPQ involved in methionine import. Binds the methionine and transfers it to the membrane-bound permease. It has also been shown to be involved in methionine sulfoxide transport (Probable).Curated

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU32730-MONOMER.

Protein family/group databases

TCDBi3.A.1.24.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine-binding lipoprotein MetQ
Gene namesi
Name:metQ
Synonyms:yusA
Ordered Locus Names:BSU32730
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19PROSITE-ProRule annotationAdd BLAST19
ChainiPRO_000038364520 – 274Methionine-binding lipoprotein MetQAdd BLAST255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi20N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi20S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiO32167.

Expressioni

Inductioni

Repressed by methionine via the S-box system.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetP) and a solute-binding protein (metQ).By similarity

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100017761.

Structurei

Secondary structure

1274
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 37Combined sources6
Turni39 – 41Combined sources3
Helixi42 – 54Combined sources13
Turni55 – 57Combined sources3
Beta strandi59 – 63Combined sources5
Helixi70 – 76Combined sources7
Beta strandi81 – 87Combined sources7
Helixi88 – 97Combined sources10
Beta strandi103 – 111Combined sources9
Beta strandi115 – 117Combined sources3
Helixi124 – 126Combined sources3
Beta strandi132 – 136Combined sources5
Helixi139 – 141Combined sources3
Helixi142 – 151Combined sources10
Helixi163 – 165Combined sources3
Helixi168 – 170Combined sources3
Beta strandi171 – 173Combined sources3
Beta strandi179 – 183Combined sources5
Turni185 – 187Combined sources3
Helixi188 – 193Combined sources6
Beta strandi197 – 202Combined sources6
Helixi204 – 209Combined sources6
Helixi214 – 217Combined sources4
Beta strandi219 – 221Combined sources3
Beta strandi231 – 236Combined sources6
Helixi243 – 252Combined sources10
Helixi255 – 264Combined sources10
Turni265 – 267Combined sources3
Beta strandi268 – 271Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GOTX-ray1.95A27-274[»]
ProteinModelPortaliO32167.
SMRiO32167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NlpA lipoprotein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105D01. Bacteria.
COG1464. LUCA.
HOGENOMiHOG000222927.
InParanoidiO32167.
KOiK02073.
OMAiGTHLVKT.
PhylomeDBiO32167.

Family and domain databases

InterProiIPR004872. Lipoprotein_NlpA.
[Graphical view]
PANTHERiPTHR30429. PTHR30429. 1 hit.
PfamiPF03180. Lipoprotein_9. 1 hit.
[Graphical view]
PIRSFiPIRSF002854. MetQ. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O32167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLFLGALL LVFAGVMAAC GSNNGAESGK KEIVVAATKT PHAEILKEAE
60 70 80 90 100
PLLKEKGYTL KVKVLSDYKM YNKALADKEV DANYFQHIPY LEQEMKENTD
110 120 130 140 150
YKLVNAGAVH LEPFGIYSKT YKSLKDLPDG ATIILTNNVA EQGRMLAMLE
160 170 180 190 200
NAGLITLDSK VETVDATLKD IKKNPKNLEF KKVAPELTAK AYENKEGDAV
210 220 230 240 250
FINVNYAIQN KLNPKKDAIE VESTKNNPYA NIIAVRKGEE DSAKIKALME
260 270
VLHSKKIKDF IEKKYDGAVL PVSE
Length:274
Mass (Da):30,355
Last modified:January 1, 1998 - v1
Checksum:i3D40F949A1BFC73C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB15262.1.
PIRiB70020.
RefSeqiNP_391152.1. NC_000964.3.
WP_003228595.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15262; CAB15262; BSU32730.
GeneIDi936716.
KEGGibsu:BSU32730.
PATRICi18978526. VBIBacSub10457_3426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB15262.1.
PIRiB70020.
RefSeqiNP_391152.1. NC_000964.3.
WP_003228595.1. NZ_JNCM01000033.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GOTX-ray1.95A27-274[»]
ProteinModelPortaliO32167.
SMRiO32167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100017761.

Protein family/group databases

TCDBi3.A.1.24.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiO32167.

Protocols and materials databases

DNASUi936716.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15262; CAB15262; BSU32730.
GeneIDi936716.
KEGGibsu:BSU32730.
PATRICi18978526. VBIBacSub10457_3426.

Phylogenomic databases

eggNOGiENOG4105D01. Bacteria.
COG1464. LUCA.
HOGENOMiHOG000222927.
InParanoidiO32167.
KOiK02073.
OMAiGTHLVKT.
PhylomeDBiO32167.

Enzyme and pathway databases

BioCyciBSUB:BSU32730-MONOMER.

Family and domain databases

InterProiIPR004872. Lipoprotein_NlpA.
[Graphical view]
PANTHERiPTHR30429. PTHR30429. 1 hit.
PfamiPF03180. Lipoprotein_9. 1 hit.
[Graphical view]
PIRSFiPIRSF002854. MetQ. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMETQ_BACSU
AccessioniPrimary (citable) accession number: O32167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.