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O32167

- METQ_BACSU

UniProt

O32167 - METQ_BACSU

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Protein
Methionine-binding lipoprotein MetQ
Gene
metQ, yusA, BSU32730
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex MetNPQ involved in methionine import. Binds the methionine and transfers it to the membrane-bound permease. It has also been shown to be involved in methionine sulfoxide transport Inferred.1 Publication

GO - Biological processi

  1. amino acid transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU32730-MONOMER.

Protein family/group databases

TCDBi3.A.1.24.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine-binding lipoprotein MetQ
Gene namesi
Name:metQ
Synonyms:yusA
Ordered Locus Names:BSU32730
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU32730. [Micado]

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 274255Methionine-binding lipoprotein MetQ
PRO_0000383645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi20 – 201N-palmitoyl cysteine Reviewed prediction
Lipidationi20 – 201S-diacylglycerol cysteine Reviewed prediction

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiO32167.

Expressioni

Inductioni

Repressed by methionine via the S-box system.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetP) and a solute-binding protein (metQ) By similarity.

Protein-protein interaction databases

STRINGi224308.BSU32730.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 376
Turni39 – 413
Helixi42 – 5413
Turni55 – 573
Beta strandi59 – 635
Helixi70 – 767
Beta strandi81 – 877
Helixi88 – 9710
Beta strandi103 – 1119
Beta strandi115 – 1173
Helixi124 – 1263
Beta strandi132 – 1365
Helixi139 – 1413
Helixi142 – 15110
Helixi163 – 1653
Helixi168 – 1703
Beta strandi171 – 1733
Beta strandi179 – 1835
Turni185 – 1873
Helixi188 – 1936
Beta strandi197 – 2026
Helixi204 – 2096
Helixi214 – 2174
Beta strandi219 – 2213
Beta strandi231 – 2366
Helixi243 – 25210
Helixi255 – 26410
Turni265 – 2673
Beta strandi268 – 2714

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GOTX-ray1.95A27-274[»]
ProteinModelPortaliO32167.
SMRiO32167. Positions 32-274.

Family & Domainsi

Sequence similaritiesi

Belongs to the NlpA lipoprotein family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1464.
HOGENOMiHOG000222927.
KOiK02073.
OMAiPKNLEFK.
OrthoDBiEOG6P073X.
PhylomeDBiO32167.

Family and domain databases

InterProiIPR004872. Lipoprotein_NlpA.
[Graphical view]
PfamiPF03180. Lipoprotein_9. 1 hit.
[Graphical view]
PIRSFiPIRSF002854. MetQ. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O32167-1 [UniParc]FASTAAdd to Basket

« Hide

MKKLFLGALL LVFAGVMAAC GSNNGAESGK KEIVVAATKT PHAEILKEAE    50
PLLKEKGYTL KVKVLSDYKM YNKALADKEV DANYFQHIPY LEQEMKENTD 100
YKLVNAGAVH LEPFGIYSKT YKSLKDLPDG ATIILTNNVA EQGRMLAMLE 150
NAGLITLDSK VETVDATLKD IKKNPKNLEF KKVAPELTAK AYENKEGDAV 200
FINVNYAIQN KLNPKKDAIE VESTKNNPYA NIIAVRKGEE DSAKIKALME 250
VLHSKKIKDF IEKKYDGAVL PVSE 274
Length:274
Mass (Da):30,355
Last modified:January 1, 1998 - v1
Checksum:i3D40F949A1BFC73C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB15262.1.
PIRiB70020.
RefSeqiNP_391152.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15262; CAB15262; BSU32730.
GeneIDi936716.
KEGGibsu:BSU32730.
PATRICi18978526. VBIBacSub10457_3426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB15262.1 .
PIRi B70020.
RefSeqi NP_391152.1. NC_000964.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GOT X-ray 1.95 A 27-274 [» ]
ProteinModelPortali O32167.
SMRi O32167. Positions 32-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU32730.

Protein family/group databases

TCDBi 3.A.1.24.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbi O32167.

Protocols and materials databases

DNASUi 936716.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15262 ; CAB15262 ; BSU32730 .
GeneIDi 936716.
KEGGi bsu:BSU32730.
PATRICi 18978526. VBIBacSub10457_3426.

Organism-specific databases

GenoListi BSU32730. [Micado ]

Phylogenomic databases

eggNOGi COG1464.
HOGENOMi HOG000222927.
KOi K02073.
OMAi PKNLEFK.
OrthoDBi EOG6P073X.
PhylomeDBi O32167.

Enzyme and pathway databases

BioCyci BSUB:BSU32730-MONOMER.

Family and domain databases

InterProi IPR004872. Lipoprotein_NlpA.
[Graphical view ]
Pfami PF03180. Lipoprotein_9. 1 hit.
[Graphical view ]
PIRSFi PIRSF002854. MetQ. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  2. "The metNPQ operon of Bacillus subtilis encodes an ABC permease transporting methionine sulfoxide, D- and L-methionine."
    Hullo M.-F., Auger S., Dassa E., Danchin A., Martin-Verstraete I.
    Res. Microbiol. 155:80-86(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROBABLE FUNCTION IN METHIONINE AND METHIONINE SULFOXIDE TRANSPORT, INDUCTION.
    Strain: 168.

Entry informationi

Entry nameiMETQ_BACSU
AccessioniPrimary (citable) accession number: O32167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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