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O32167

- METQ_BACSU

UniProt

O32167 - METQ_BACSU

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Protein

Methionine-binding lipoprotein MetQ

Gene

metQ

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex MetNPQ involved in methionine import. Binds the methionine and transfers it to the membrane-bound permease. It has also been shown to be involved in methionine sulfoxide transport (Probable).Curated

GO - Biological processi

  1. amino acid transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU32730-MONOMER.

Protein family/group databases

TCDBi3.A.1.24.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine-binding lipoprotein MetQ
Gene namesi
Name:metQ
Synonyms:yusA
Ordered Locus Names:BSU32730
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU32730. [Micado]

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919PROSITE-ProRule annotationAdd
BLAST
Chaini20 – 274255Methionine-binding lipoprotein MetQPRO_0000383645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi20 – 201N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi20 – 201S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiO32167.

Expressioni

Inductioni

Repressed by methionine via the S-box system.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetP) and a solute-binding protein (metQ).By similarity

Protein-protein interaction databases

STRINGi224308.BSU32730.

Structurei

Secondary structure

1
274
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 376Combined sources
Turni39 – 413Combined sources
Helixi42 – 5413Combined sources
Turni55 – 573Combined sources
Beta strandi59 – 635Combined sources
Helixi70 – 767Combined sources
Beta strandi81 – 877Combined sources
Helixi88 – 9710Combined sources
Beta strandi103 – 1119Combined sources
Beta strandi115 – 1173Combined sources
Helixi124 – 1263Combined sources
Beta strandi132 – 1365Combined sources
Helixi139 – 1413Combined sources
Helixi142 – 15110Combined sources
Helixi163 – 1653Combined sources
Helixi168 – 1703Combined sources
Beta strandi171 – 1733Combined sources
Beta strandi179 – 1835Combined sources
Turni185 – 1873Combined sources
Helixi188 – 1936Combined sources
Beta strandi197 – 2026Combined sources
Helixi204 – 2096Combined sources
Helixi214 – 2174Combined sources
Beta strandi219 – 2213Combined sources
Beta strandi231 – 2366Combined sources
Helixi243 – 25210Combined sources
Helixi255 – 26410Combined sources
Turni265 – 2673Combined sources
Beta strandi268 – 2714Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GOTX-ray1.95A27-274[»]
ProteinModelPortaliO32167.
SMRiO32167. Positions 32-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NlpA lipoprotein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1464.
HOGENOMiHOG000222927.
InParanoidiO32167.
KOiK02073.
OMAiPKNLEFK.
OrthoDBiEOG6P073X.
PhylomeDBiO32167.

Family and domain databases

InterProiIPR004872. Lipoprotein_NlpA.
[Graphical view]
PfamiPF03180. Lipoprotein_9. 1 hit.
[Graphical view]
PIRSFiPIRSF002854. MetQ. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O32167-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKLFLGALL LVFAGVMAAC GSNNGAESGK KEIVVAATKT PHAEILKEAE
60 70 80 90 100
PLLKEKGYTL KVKVLSDYKM YNKALADKEV DANYFQHIPY LEQEMKENTD
110 120 130 140 150
YKLVNAGAVH LEPFGIYSKT YKSLKDLPDG ATIILTNNVA EQGRMLAMLE
160 170 180 190 200
NAGLITLDSK VETVDATLKD IKKNPKNLEF KKVAPELTAK AYENKEGDAV
210 220 230 240 250
FINVNYAIQN KLNPKKDAIE VESTKNNPYA NIIAVRKGEE DSAKIKALME
260 270
VLHSKKIKDF IEKKYDGAVL PVSE
Length:274
Mass (Da):30,355
Last modified:January 1, 1998 - v1
Checksum:i3D40F949A1BFC73C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB15262.1.
PIRiB70020.
RefSeqiNP_391152.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15262; CAB15262; BSU32730.
GeneIDi936716.
KEGGibsu:BSU32730.
PATRICi18978526. VBIBacSub10457_3426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB15262.1 .
PIRi B70020.
RefSeqi NP_391152.1. NC_000964.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GOT X-ray 1.95 A 27-274 [» ]
ProteinModelPortali O32167.
SMRi O32167. Positions 32-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU32730.

Protein family/group databases

TCDBi 3.A.1.24.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbi O32167.

Protocols and materials databases

DNASUi 936716.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15262 ; CAB15262 ; BSU32730 .
GeneIDi 936716.
KEGGi bsu:BSU32730.
PATRICi 18978526. VBIBacSub10457_3426.

Organism-specific databases

GenoListi BSU32730. [Micado ]

Phylogenomic databases

eggNOGi COG1464.
HOGENOMi HOG000222927.
InParanoidi O32167.
KOi K02073.
OMAi PKNLEFK.
OrthoDBi EOG6P073X.
PhylomeDBi O32167.

Enzyme and pathway databases

BioCyci BSUB:BSU32730-MONOMER.

Family and domain databases

InterProi IPR004872. Lipoprotein_NlpA.
[Graphical view ]
Pfami PF03180. Lipoprotein_9. 1 hit.
[Graphical view ]
PIRSFi PIRSF002854. MetQ. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  2. "The metNPQ operon of Bacillus subtilis encodes an ABC permease transporting methionine sulfoxide, D- and L-methionine."
    Hullo M.-F., Auger S., Dassa E., Danchin A., Martin-Verstraete I.
    Res. Microbiol. 155:80-86(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROBABLE FUNCTION IN METHIONINE AND METHIONINE SULFOXIDE TRANSPORT, INDUCTION.
    Strain: 168.

Entry informationi

Entry nameiMETQ_BACSU
AccessioniPrimary (citable) accession number: O32167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3