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O32147

- XDHA_BACSU

UniProt

O32147 - XDHA_BACSU

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Protein

Probable xanthine dehydrogenase subunit A

Gene
pucA, yurF, BSU32510
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Oxidizes hypoxanthine and xanthine to uric acid. PucA subunit could exert a molybdenum cofactor recruiting function.1 Publication

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Pathwayi

GO - Molecular functioni

  1. xanthine dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. hypoxanthine catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBSUB:BSU32510-MONOMER.
UniPathwayiUPA00604; UER00661.
UPA00604; UER00662.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable xanthine dehydrogenase subunit A (EC:1.17.1.4)
Short name:
XDHase subunit A
Gene namesi
Name:pucA
Synonyms:yurF
Ordered Locus Names:BSU32510
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU32510. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Probable xanthine dehydrogenase subunit APRO_0000166100Add
BLAST

Proteomic databases

PaxDbiO32147.

Expressioni

Inductioni

Expression is very low in excess nitrogen (glutamate plus ammonia) and is induced during limiting-nitrogen conditions (glutamate). Expression decreases when allantoin is added during limiting-nitrogen conditions.

Interactioni

Subunit structurei

Could be composed of four subunits: PucA, PucC, PucD and PucE.

Protein-protein interaction databases

STRINGi224308.BSU32510.

Structurei

3D structure databases

ProteinModelPortaliO32147.
SMRiO32147. Positions 1-326.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1975.
HOGENOMiHOG000244666.
KOiK00087.
OMAiLGWHVTV.
OrthoDBiEOG680X47.
PhylomeDBiO32147.

Family and domain databases

InterProiIPR003777. XdhC_CoxI.
IPR027051. XdhC_Rossmann_dom.
[Graphical view]
PfamiPF13478. XdhC_C. 1 hit.
PF02625. XdhC_CoxI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O32147-1 [UniParc]FASTAAdd to Basket

« Hide

MGNFHTMLDA LLEDQEEAVL ATIVQVEGSA YRKAGASMLF KKKGRRIGLL    50
SGGCVEEDVF QRISALGDQL TSTLIPYDMR SEDDLSWGMG AGCNGIIHVH 100
AERITQEKRR HYEKVRDCLH SGKAVTSVIK IESSHYLFLT ENGHFGNWPD 150
APLQDIQRTV STLHLPHFDQ TTNMFIQRIE PKPRLILFGA GPDNVPLANL 200
AADTGFSVIV TDWRPAYCTS SLFPKADQLI TAFPEQMLSE FQFFPHDAAV 250
VATHHYQHDQ TIINFLFSQN LHYIGLLGSA NRTKRLLSGK HPPSHFYSPV 300
GLKIGAEGPE EIAVSVVAEI IQTRKRVAVV 330
Length:330
Mass (Da):36,746
Last modified:January 1, 1998 - v1
Checksum:iE4A70B2155BE1902
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB15241.1.
PIRiE70017.
RefSeqiNP_391131.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15241; CAB15241; BSU32510.
GeneIDi938865.
KEGGibsu:BSU32510.
PATRICi18978476. VBIBacSub10457_3401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB15241.1 .
PIRi E70017.
RefSeqi NP_391131.1. NC_000964.3.

3D structure databases

ProteinModelPortali O32147.
SMRi O32147. Positions 1-326.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU32510.

Proteomic databases

PaxDbi O32147.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15241 ; CAB15241 ; BSU32510 .
GeneIDi 938865.
KEGGi bsu:BSU32510.
PATRICi 18978476. VBIBacSub10457_3401.

Organism-specific databases

GenoListi BSU32510. [Micado ]

Phylogenomic databases

eggNOGi COG1975.
HOGENOMi HOG000244666.
KOi K00087.
OMAi LGWHVTV.
OrthoDBi EOG680X47.
PhylomeDBi O32147.

Enzyme and pathway databases

UniPathwayi UPA00604 ; UER00661 .
UPA00604 ; UER00662 .
BioCyci BSUB:BSU32510-MONOMER.

Family and domain databases

InterProi IPR003777. XdhC_CoxI.
IPR027051. XdhC_Rossmann_dom.
[Graphical view ]
Pfami PF13478. XdhC_C. 1 hit.
PF02625. XdhC_CoxI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  2. "Functional analysis of 14 genes that constitute the purine catabolic pathway in Bacillus subtilis and evidence for a novel regulon controlled by the PucR transcription activator."
    Schultz A.C., Nygaard P., Saxild H.H.
    J. Bacteriol. 183:3293-3302(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: 168.

Entry informationi

Entry nameiXDHA_BACSU
AccessioniPrimary (citable) accession number: O32147
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

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