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O32147

- XDHA_BACSU

UniProt

O32147 - XDHA_BACSU

Protein

Probable xanthine dehydrogenase subunit A

Gene

pucA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Oxidizes hypoxanthine and xanthine to uric acid. PucA subunit could exert a molybdenum cofactor recruiting function.1 Publication

    Catalytic activityi

    Xanthine + NAD+ + H2O = urate + NADH.
    Hypoxanthine + NAD+ + H2O = xanthine + NADH.

    Pathwayi

    GO - Molecular functioni

    1. xanthine dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. hypoxanthine catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Purine metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBSUB:BSU32510-MONOMER.
    UniPathwayiUPA00604; UER00661.
    UPA00604; UER00662.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable xanthine dehydrogenase subunit A (EC:1.17.1.4)
    Short name:
    XDHase subunit A
    Gene namesi
    Name:pucA
    Synonyms:yurF
    Ordered Locus Names:BSU32510
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU32510. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Probable xanthine dehydrogenase subunit APRO_0000166100Add
    BLAST

    Proteomic databases

    PaxDbiO32147.

    Expressioni

    Inductioni

    Expression is very low in excess nitrogen (glutamate plus ammonia) and is induced during limiting-nitrogen conditions (glutamate). Expression decreases when allantoin is added during limiting-nitrogen conditions.

    Interactioni

    Subunit structurei

    Could be composed of four subunits: PucA, PucC, PucD and PucE.

    Protein-protein interaction databases

    STRINGi224308.BSU32510.

    Structurei

    3D structure databases

    ProteinModelPortaliO32147.
    SMRiO32147. Positions 1-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1975.
    HOGENOMiHOG000244666.
    KOiK00087.
    OMAiLGWHVTV.
    OrthoDBiEOG680X47.
    PhylomeDBiO32147.

    Family and domain databases

    InterProiIPR003777. XdhC_CoxI.
    IPR027051. XdhC_Rossmann_dom.
    [Graphical view]
    PfamiPF13478. XdhC_C. 1 hit.
    PF02625. XdhC_CoxI. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O32147-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNFHTMLDA LLEDQEEAVL ATIVQVEGSA YRKAGASMLF KKKGRRIGLL    50
    SGGCVEEDVF QRISALGDQL TSTLIPYDMR SEDDLSWGMG AGCNGIIHVH 100
    AERITQEKRR HYEKVRDCLH SGKAVTSVIK IESSHYLFLT ENGHFGNWPD 150
    APLQDIQRTV STLHLPHFDQ TTNMFIQRIE PKPRLILFGA GPDNVPLANL 200
    AADTGFSVIV TDWRPAYCTS SLFPKADQLI TAFPEQMLSE FQFFPHDAAV 250
    VATHHYQHDQ TIINFLFSQN LHYIGLLGSA NRTKRLLSGK HPPSHFYSPV 300
    GLKIGAEGPE EIAVSVVAEI IQTRKRVAVV 330
    Length:330
    Mass (Da):36,746
    Last modified:January 1, 1998 - v1
    Checksum:iE4A70B2155BE1902
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB15241.1.
    PIRiE70017.
    RefSeqiNP_391131.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB15241; CAB15241; BSU32510.
    GeneIDi938865.
    KEGGibsu:BSU32510.
    PATRICi18978476. VBIBacSub10457_3401.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB15241.1 .
    PIRi E70017.
    RefSeqi NP_391131.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali O32147.
    SMRi O32147. Positions 1-326.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU32510.

    Proteomic databases

    PaxDbi O32147.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB15241 ; CAB15241 ; BSU32510 .
    GeneIDi 938865.
    KEGGi bsu:BSU32510.
    PATRICi 18978476. VBIBacSub10457_3401.

    Organism-specific databases

    GenoListi BSU32510. [Micado ]

    Phylogenomic databases

    eggNOGi COG1975.
    HOGENOMi HOG000244666.
    KOi K00087.
    OMAi LGWHVTV.
    OrthoDBi EOG680X47.
    PhylomeDBi O32147.

    Enzyme and pathway databases

    UniPathwayi UPA00604 ; UER00661 .
    UPA00604 ; UER00662 .
    BioCyci BSUB:BSU32510-MONOMER.

    Family and domain databases

    InterProi IPR003777. XdhC_CoxI.
    IPR027051. XdhC_Rossmann_dom.
    [Graphical view ]
    Pfami PF13478. XdhC_C. 1 hit.
    PF02625. XdhC_CoxI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    2. "Functional analysis of 14 genes that constitute the purine catabolic pathway in Bacillus subtilis and evidence for a novel regulon controlled by the PucR transcription activator."
      Schultz A.C., Nygaard P., Saxild H.H.
      J. Bacteriol. 183:3293-3302(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: 168.

    Entry informationi

    Entry nameiXDHA_BACSU
    AccessioniPrimary (citable) accession number: O32147
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3