Reviewed,
UniProtKB/Swiss-Prot O32145 (XDHC_BACSU)
Last modified
February 9, 2010.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable xanthine dehydrogenase subunit C Short name=XDHase subunit C EC=1.17.1.4 | ||||||
| Gene names |
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| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1423 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 277 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Oxidizes hypoxanthine and xanthine to uric acid. Ref.2 |
| Catalytic activity | Xanthine + NAD+ + H2O = urate + NADH. Hypoxanthine + NAD+ + H2O = xanthine + NADH. |
| Cofactor | FAD By similarity. |
| Pathway | Purine metabolism; hypoxanthine degradation; urate from hypoxanthine: step 1/2. Purine metabolism; hypoxanthine degradation; urate from hypoxanthine: step 2/2. |
| Subunit structure | Could be composed of four subunits: pucA, pucC, pucD and pucE. |
| Induction | Expression is very low in excess nitrogen (glutamate plus ammonia) and is induced during limiting-nitrogen conditions (glutamate). Expression decreases when allantoin is added during limiting-nitrogen conditions. |
| Sequence similarities | Contains 1 FAD-binding PCMH-type domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine metabolism |
| Ligand | FAD Flavoprotein NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW purine base metabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | FAD binding Inferred from electronic annotation. Source: InterPro xanthine dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [2] | "Functional analysis of 14 genes that constitute the purine catabolic pathway in Bacillus subtilis and evidence for a novel regulon controlled by the PucR transcription activator." Schultz A.C., Nygaard P., Saxild H.H. J. Bacteriol. 183:3293-3302(2001) [PubMed: 11344136] [Abstract] Cited for: FUNCTION. Strain: 168. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL009126 Genomic DNA. Translation: CAB15239.1. |
| PIR | C70017. |
| RefSeq | NP_391129.1. |
3D structure databases | |
| SMR | O32145. Positions 12-271. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 936685. |
| GenomeReviews | Gene locus BSU32490 in contig AL009126_GR. |
| KEGG | bsu:BSU32490. |
| NMPDR | fig|224308.1.peg.3255. |
Organism-specific databases | |
| SubtiList | BG13990. pucC. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| OMA | MITIKEY. |
Enzyme and pathway databases | |
| BRENDA | 1.17.1.4. 150. |
Family and domain databases | |
| InterPro | IPR005107. CO_DH_flav_C. IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR002346. Mopterin_DH_FAD-bd. IPR017612. Xanthine_dehydrogenase_csu. [Graphical view] |
| Gene3D | G3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit. |
| Pfam | PF00941. FAD_binding_5. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03199. pucC. 1 hit. |
| PROSITE | PS51387. FAD_PCMH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | XDHC_BACSU | ||||||||
| Accession | Primary (citable) accession number: O32145 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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