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Protein

Probable xanthine dehydrogenase subunit C

Gene

pucC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Oxidizes hypoxanthine and xanthine to uric acid.1 Publication

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

FADBy similarity

Pathwayi: hypoxanthine degradation

This protein is involved in step 1 and 2 of the subpathway that synthesizes urate from hypoxanthine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable xanthine dehydrogenase subunit C (pucC), Probable xanthine dehydrogenase subunit A (pucA), Probable xanthine dehydrogenase subunit D (pucD), Probable xanthine dehydrogenase subunit E (pucE)
  2. Probable xanthine dehydrogenase subunit C (pucC), Probable xanthine dehydrogenase subunit A (pucA), Probable xanthine dehydrogenase subunit D (pucD), Probable xanthine dehydrogenase subunit E (pucE)
This subpathway is part of the pathway hypoxanthine degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes urate from hypoxanthine, the pathway hypoxanthine degradation and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPurine metabolism
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciBSUB:BSU32490-MONOMER
UniPathwayiUPA00604; UER00661
UPA00604; UER00662

Names & Taxonomyi

Protein namesi
Recommended name:
Probable xanthine dehydrogenase subunit C (EC:1.17.1.4)
Short name:
XDHase subunit C
Gene namesi
Name:pucC
Synonyms:yurD
Ordered Locus Names:BSU32490
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001660991 – 277Probable xanthine dehydrogenase subunit CAdd BLAST277

Proteomic databases

PaxDbiO32145

Expressioni

Inductioni

Expression is very low in excess nitrogen (glutamate plus ammonia) and is induced during limiting-nitrogen conditions (glutamate). Expression decreases when allantoin is added during limiting-nitrogen conditions.

Interactioni

Subunit structurei

Could be composed of four subunits: PucA, PucC, PucD and PucE.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100017626

Structurei

3D structure databases

ProteinModelPortaliO32145
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 176FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST170

Phylogenomic databases

eggNOGiCOG1319 LUCA
HOGENOMiHOG000154870
InParanoidiO32145
KOiK00087
OMAiKARMNIQ
PhylomeDBiO32145

Family and domain databases

InterProiView protein in InterPro
IPR036683 CO_DH_flav_C_dom_sf
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR002346 Mopterin_DH_FAD-bd
IPR017612 Xanthine_dehydrogenase_csu
PfamiView protein in Pfam
PF00941 FAD_binding_5, 1 hit
SUPFAMiSSF55447 SSF55447, 1 hit
SSF56176 SSF56176, 1 hit
TIGRFAMsiTIGR03199 pucC, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

O32145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGQVTKARM NIQLWRPAAL DEAYSLLEKL APDVCAASGS TLLQLQWDKG
60 70 80 90 100
TLPKQHLVSL EGIDEMRGIS TSDTHVSIGG LTSLNECRKN PLIKRALSCF
110 120 130 140 150
SDAASAVAAP GIRSRATIGG NIASKIGDFI PLLLVLGAEL IVYQKELIRL
160 170 180 190 200
PLGAWLSEED FRTAIVTRVI IPRAEGERVF YHKLGRRQAF TGAAAVAAGR
210 220 230 240 250
FLKDGSIRLA AGHADITPRR LLDSEAKWMA PGWDPHELYK TLIHELPFSS
260 270
DVFMSAAYRK KAAANVIMAE LMAEGGE
Length:277
Mass (Da):30,119
Last modified:January 1, 1998 - v1
Checksum:i25D8C75D6D237961
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB15239.1
PIRiC70017
RefSeqiNP_391129.1, NC_000964.3
WP_003228646.1, NZ_JNCM01000033.1

Genome annotation databases

EnsemblBacteriaiCAB15239; CAB15239; BSU32490
GeneIDi936685
KEGGibsu:BSU32490
PATRICifig|224308.179.peg.3518

Similar proteinsi

Entry informationi

Entry nameiXDHC_BACSU
AccessioniPrimary (citable) accession number: O32145
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health