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O32090 (PNCB_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11
Gene names
Name:pncB
Synonyms:yueK
Ordered Locus Names:BSU31750
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.

Catalytic activity

Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Nicotinate phosphoribosyltransferase
PRO_0000360847

Sequences

Sequence LengthMass (Da)Tools
O32090 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 02EC55FF5B3EF83D

FASTA49056,180
        10         20         30         40         50         60 
MLEYGFKDDS LSLHTDLYQI NMAETYWRDG IHEKKAIFEL FFRRLPFENG YAVFAGLEKA 

        70         80         90        100        110        120 
IEYLENFKFT DSDLSYLQDE LGYHEDFIEY LRGLSFTGSL YSMKEGELVF NNEPIMRVEA 

       130        140        150        160        170        180 
PLVEAQLIET ALLNIVNYQT LIATKAARIK GVIGDEVALE FGTRRAHEMD AAMWGARAAL 

       190        200        210        220        230        240 
IGGFSATSNV RAGKRFNIPV SGTHAHALVQ AYRDEYTAFK KYAETHKDCV FLVDTYDTLR 

       250        260        270        280        290        300 
SGMPNAIRVA KEFGDRINFI GIRLDSGDLA YLSKKARKML DEAGFTDAKV IASSDLDEHT 

       310        320        330        340        350        360 
IMNLKAQGAR IDVWGVGTKL ITAYDQPALG AVYKLVAIEE DGKMVDTIKI SSNPEKVTTP 

       370        380        390        400        410        420 
GRKKVYRIIN QSNHHSEGDY IALYDEQVND QKRLRMFHPV HTFISKFVTN FYAKDLHELI 

       430        440        450        460        470        480 
FEKGILCYQN PEISDIQQYV QDNLSLLWEE YKRISKPEEY PVDLSEDCWS NKMQRIHEVK 

       490 
SRIEEELEEE

« Hide

References

[1]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL009126 Genomic DNA. Translation: CAB15163.1.
PIRD70008.
RefSeqNP_391053.1. NC_000964.3.

3D structure databases

HSSPHSSP built from PDB template 2F7F based on UniProtKB Q830Y8.
ProteinModelPortalO32090.
SMRO32090. Positions 6-484.
ModBaseSearch...

Protein-protein interaction databases

STRING224308.BSU31750.

Proteomic databases

PaxDbO32090.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB15163; CAB15163; BSU31750.
GeneID937186.
KEGGbsu:BSU31750.
PATRIC18978322. VBIBacSub10457_3324.

Organism-specific databases

GenoListBSU31750. [Micado]

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000001112.
KOK00763.
OMAAVYKLVS.
ProtClustDBPRK09243.

Enzyme and pathway databases

BioCycBSUB:BSU31750-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

InterProIPR015977. Nic_PRibTrfase-like.
IPR007229. Nic_PRibTrfase-rel.
IPR006405. Nic_PRibTrfase_put.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. Q_phspho_trans. 1 hit.
TIGRFAMsTIGR01513. NAPRTase_put. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_BACSU
AccessionPrimary (citable) accession number: O32090
Entry history
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents