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O32090

- PNCB_BACSU

UniProt

O32090 - PNCB_BACSU

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN).By similarity
    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide salvage Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciBSUB:BSU31750-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
    Short name:
    NAPRTase
    Gene namesi
    Name:pncB
    Synonyms:yueK
    Ordered Locus Names:BSU31750
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU31750. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Nicotinate phosphoribosyltransferasePRO_0000360847Add
    BLAST

    Proteomic databases

    PaxDbiO32090.

    Interactioni

    Protein-protein interaction databases

    IntActiO32090. 1 interaction.
    MINTiMINT-8365860.
    STRINGi224308.BSU31750.

    Structurei

    3D structure databases

    ProteinModelPortaliO32090.
    SMRiO32090. Positions 6-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.Curated

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000001112.
    KOiK00763.
    OMAiMQVYFNQ.
    OrthoDBiEOG6D2KVQ.
    PhylomeDBiO32090.

    Family and domain databases

    InterProiIPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O32090-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEYGFKDDS LSLHTDLYQI NMAETYWRDG IHEKKAIFEL FFRRLPFENG    50
    YAVFAGLEKA IEYLENFKFT DSDLSYLQDE LGYHEDFIEY LRGLSFTGSL 100
    YSMKEGELVF NNEPIMRVEA PLVEAQLIET ALLNIVNYQT LIATKAARIK 150
    GVIGDEVALE FGTRRAHEMD AAMWGARAAL IGGFSATSNV RAGKRFNIPV 200
    SGTHAHALVQ AYRDEYTAFK KYAETHKDCV FLVDTYDTLR SGMPNAIRVA 250
    KEFGDRINFI GIRLDSGDLA YLSKKARKML DEAGFTDAKV IASSDLDEHT 300
    IMNLKAQGAR IDVWGVGTKL ITAYDQPALG AVYKLVAIEE DGKMVDTIKI 350
    SSNPEKVTTP GRKKVYRIIN QSNHHSEGDY IALYDEQVND QKRLRMFHPV 400
    HTFISKFVTN FYAKDLHELI FEKGILCYQN PEISDIQQYV QDNLSLLWEE 450
    YKRISKPEEY PVDLSEDCWS NKMQRIHEVK SRIEEELEEE 490
    Length:490
    Mass (Da):56,180
    Last modified:January 1, 1998 - v1
    Checksum:i02EC55FF5B3EF83D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB15163.1.
    PIRiD70008.
    RefSeqiNP_391053.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB15163; CAB15163; BSU31750.
    GeneIDi937186.
    KEGGibsu:BSU31750.
    PATRICi18978322. VBIBacSub10457_3324.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB15163.1 .
    PIRi D70008.
    RefSeqi NP_391053.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali O32090.
    SMRi O32090. Positions 6-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O32090. 1 interaction.
    MINTi MINT-8365860.
    STRINGi 224308.BSU31750.

    Proteomic databases

    PaxDbi O32090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB15163 ; CAB15163 ; BSU31750 .
    GeneIDi 937186.
    KEGGi bsu:BSU31750.
    PATRICi 18978322. VBIBacSub10457_3324.

    Organism-specific databases

    GenoListi BSU31750. [Micado ]

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000001112.
    KOi K00763.
    OMAi MQVYFNQ.
    OrthoDBi EOG6D2KVQ.
    PhylomeDBi O32090.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci BSUB:BSU31750-MONOMER.

    Family and domain databases

    InterProi IPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.

    Entry informationi

    Entry nameiPNCB_BACSU
    AccessioniPrimary (citable) accession number: O32090
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3