SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O32090

- PNCB_BACSU

UniProt

O32090 - PNCB_BACSU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Nicotinate phosphoribosyltransferase
Gene
pncB, yueK, BSU31750
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: InterPro
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU31750-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Synonyms:yueK
Ordered Locus Names:BSU31750
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU31750. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Nicotinate phosphoribosyltransferase
PRO_0000360847Add
BLAST

Proteomic databases

PaxDbiO32090.

Interactioni

Protein-protein interaction databases

IntActiO32090. 1 interaction.
MINTiMINT-8365860.
STRINGi224308.BSU31750.

Structurei

3D structure databases

ProteinModelPortaliO32090.
SMRiO32090. Positions 6-484.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000001112.
KOiK00763.
OMAiMQVYFNQ.
OrthoDBiEOG6D2KVQ.
PhylomeDBiO32090.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

Sequencei

Sequence statusi: Complete.

O32090-1 [UniParc]FASTAAdd to Basket

« Hide

MLEYGFKDDS LSLHTDLYQI NMAETYWRDG IHEKKAIFEL FFRRLPFENG    50
YAVFAGLEKA IEYLENFKFT DSDLSYLQDE LGYHEDFIEY LRGLSFTGSL 100
YSMKEGELVF NNEPIMRVEA PLVEAQLIET ALLNIVNYQT LIATKAARIK 150
GVIGDEVALE FGTRRAHEMD AAMWGARAAL IGGFSATSNV RAGKRFNIPV 200
SGTHAHALVQ AYRDEYTAFK KYAETHKDCV FLVDTYDTLR SGMPNAIRVA 250
KEFGDRINFI GIRLDSGDLA YLSKKARKML DEAGFTDAKV IASSDLDEHT 300
IMNLKAQGAR IDVWGVGTKL ITAYDQPALG AVYKLVAIEE DGKMVDTIKI 350
SSNPEKVTTP GRKKVYRIIN QSNHHSEGDY IALYDEQVND QKRLRMFHPV 400
HTFISKFVTN FYAKDLHELI FEKGILCYQN PEISDIQQYV QDNLSLLWEE 450
YKRISKPEEY PVDLSEDCWS NKMQRIHEVK SRIEEELEEE 490
Length:490
Mass (Da):56,180
Last modified:January 1, 1998 - v1
Checksum:i02EC55FF5B3EF83D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB15163.1.
PIRiD70008.
RefSeqiNP_391053.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15163; CAB15163; BSU31750.
GeneIDi937186.
KEGGibsu:BSU31750.
PATRICi18978322. VBIBacSub10457_3324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB15163.1 .
PIRi D70008.
RefSeqi NP_391053.1. NC_000964.3.

3D structure databases

ProteinModelPortali O32090.
SMRi O32090. Positions 6-484.
ModBasei Search...

Protein-protein interaction databases

IntActi O32090. 1 interaction.
MINTi MINT-8365860.
STRINGi 224308.BSU31750.

Proteomic databases

PaxDbi O32090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15163 ; CAB15163 ; BSU31750 .
GeneIDi 937186.
KEGGi bsu:BSU31750.
PATRICi 18978322. VBIBacSub10457_3324.

Organism-specific databases

GenoListi BSU31750. [Micado ]

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000001112.
KOi K00763.
OMAi MQVYFNQ.
OrthoDBi EOG6D2KVQ.
PhylomeDBi O32090.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci BSUB:BSU31750-MONOMER.

Family and domain databases

InterProi IPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.

Entry informationi

Entry nameiPNCB_BACSU
AccessioniPrimary (citable) accession number: O32090
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi