Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O32085

- CDOA_BACSU

UniProt

O32085 - CDOA_BACSU

Protein

Cysteine dioxygenase

Gene

cdoA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    L-cysteine + O2 = 3-sulfinoalanine.1 Publication

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Kineticsi

    1. KM=3.0 mM for cysteine1 Publication

    pH dependencei

    Optimum pH is 6.2.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi75 – 751Iron; catalyticBy similarity
    Metal bindingi77 – 771Iron; catalyticBy similarity
    Metal bindingi125 – 1251Iron; catalyticBy similarity

    GO - Molecular functioni

    1. cysteine dioxygenase activity Source: UniProtKB-EC
    2. iron ion binding Source: InterPro

    GO - Biological processi

    1. L-cysteine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBSUB:BSU31140-MONOMER.
    BRENDAi1.13.11.20. 700.
    SABIO-RKO32085.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine dioxygenase (EC:1.13.11.20)
    Short name:
    CDO
    Gene namesi
    Name:cdoA
    Synonyms:yubC
    Ordered Locus Names:BSU31140
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU31140. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161Cysteine dioxygenasePRO_0000360761Add
    BLAST

    Proteomic databases

    PaxDbiO32085.

    Expressioni

    Developmental stagei

    Up-regulated upon sporulation.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU31140.

    Structurei

    Secondary structure

    1
    161
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 119
    Helixi19 – 268
    Helixi32 – 365
    Beta strandi44 – 5512
    Beta strandi60 – 667
    Beta strandi81 – 9818
    Beta strandi100 – 11213
    Beta strandi116 – 1194
    Beta strandi124 – 1285
    Beta strandi131 – 1333
    Beta strandi135 – 1439

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3EQEX-ray2.82A/B1-161[»]
    ProteinModelPortaliO32085.
    SMRiO32085. Positions 1-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO32085.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cysteine dioxygenase family.Curated

    Phylogenomic databases

    eggNOGiNOG236067.
    HOGENOMiHOG000080196.
    OMAiCILIVNG.
    OrthoDBiEOG67X1TS.
    PhylomeDBiO32085.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF05995. CDO_I. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O32085-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELYECIQDI FGGLKNPSVK DLATSLKQIP NAAKLSQPYI KEPDQYAYGR    50
    NAIYRNNELE IIVINIPPNK ETTVHDHGQS IGCAMVLEGK LLNSIYRSTG 100
    EHAELSNSYF VHEGECLIST KGLIHKMSNP TSERMVSLHV YSPPLEDMTV 150
    FEEQKEVLEN S 161
    Length:161
    Mass (Da):18,127
    Last modified:January 1, 1998 - v1
    Checksum:i9580D43AE8AFE016
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB15092.1.
    PIRiF70006.
    RefSeqiNP_390992.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB15092; CAB15092; BSU31140.
    GeneIDi938837.
    KEGGibsu:BSU31140.
    PATRICi18978182. VBIBacSub10457_3255.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB15092.1 .
    PIRi F70006.
    RefSeqi NP_390992.1. NC_000964.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3EQE X-ray 2.82 A/B 1-161 [» ]
    ProteinModelPortali O32085.
    SMRi O32085. Positions 1-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU31140.

    Proteomic databases

    PaxDbi O32085.

    Protocols and materials databases

    DNASUi 938837.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB15092 ; CAB15092 ; BSU31140 .
    GeneIDi 938837.
    KEGGi bsu:BSU31140.
    PATRICi 18978182. VBIBacSub10457_3255.

    Organism-specific databases

    GenoListi BSU31140. [Micado ]

    Phylogenomic databases

    eggNOGi NOG236067.
    HOGENOMi HOG000080196.
    OMAi CILIVNG.
    OrthoDBi EOG67X1TS.
    PhylomeDBi O32085.

    Enzyme and pathway databases

    BioCyci BSUB:BSU31140-MONOMER.
    BRENDAi 1.13.11.20. 700.
    SABIO-RK O32085.

    Miscellaneous databases

    EvolutionaryTracei O32085.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF05995. CDO_I. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    2. "Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria."
      Dominy J.E. Jr., Simmons C.R., Karplus P.A., Gehring A.M., Stipanuk M.H.
      J. Bacteriol. 188:5561-5569(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCDOA_BACSU
    AccessioniPrimary (citable) accession number: O32085
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3