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O32085

- CDOA_BACSU

UniProt

O32085 - CDOA_BACSU

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Protein

Cysteine dioxygenase

Gene

cdoA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.1 Publication

Cofactori

Binds 1 iron ion per subunit.By similarity

Kineticsi

  1. KM=3.0 mM for cysteine1 Publication

pH dependencei

Optimum pH is 6.2.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Iron; catalyticBy similarity
Metal bindingi77 – 771Iron; catalyticBy similarity
Metal bindingi125 – 1251Iron; catalyticBy similarity

GO - Molecular functioni

  1. cysteine dioxygenase activity Source: UniProtKB-EC
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. L-cysteine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU31140-MONOMER.
BRENDAi1.13.11.20. 700.
SABIO-RKO32085.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase (EC:1.13.11.20)
Short name:
CDO
Gene namesi
Name:cdoA
Synonyms:yubC
Ordered Locus Names:BSU31140
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU31140. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Cysteine dioxygenasePRO_0000360761Add
BLAST

Proteomic databases

PaxDbiO32085.

Expressioni

Developmental stagei

Up-regulated upon sporulation.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU31140.

Structurei

Secondary structure

1
161
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 119
Helixi19 – 268
Helixi32 – 365
Beta strandi44 – 5512
Beta strandi60 – 667
Beta strandi81 – 9818
Beta strandi100 – 11213
Beta strandi116 – 1194
Beta strandi124 – 1285
Beta strandi131 – 1333
Beta strandi135 – 1439

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EQEX-ray2.82A/B1-161[»]
ProteinModelPortaliO32085.
SMRiO32085. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO32085.

Family & Domainsi

Sequence similaritiesi

Belongs to the cysteine dioxygenase family.Curated

Phylogenomic databases

eggNOGiNOG236067.
HOGENOMiHOG000080196.
InParanoidiO32085.
OMAiCILIVNG.
OrthoDBiEOG67X1TS.
PhylomeDBiO32085.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

O32085-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELYECIQDI FGGLKNPSVK DLATSLKQIP NAAKLSQPYI KEPDQYAYGR
60 70 80 90 100
NAIYRNNELE IIVINIPPNK ETTVHDHGQS IGCAMVLEGK LLNSIYRSTG
110 120 130 140 150
EHAELSNSYF VHEGECLIST KGLIHKMSNP TSERMVSLHV YSPPLEDMTV
160
FEEQKEVLEN S
Length:161
Mass (Da):18,127
Last modified:January 1, 1998 - v1
Checksum:i9580D43AE8AFE016
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB15092.1.
PIRiF70006.
RefSeqiNP_390992.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15092; CAB15092; BSU31140.
GeneIDi938837.
KEGGibsu:BSU31140.
PATRICi18978182. VBIBacSub10457_3255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB15092.1 .
PIRi F70006.
RefSeqi NP_390992.1. NC_000964.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3EQE X-ray 2.82 A/B 1-161 [» ]
ProteinModelPortali O32085.
SMRi O32085. Positions 1-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU31140.

Proteomic databases

PaxDbi O32085.

Protocols and materials databases

DNASUi 938837.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15092 ; CAB15092 ; BSU31140 .
GeneIDi 938837.
KEGGi bsu:BSU31140.
PATRICi 18978182. VBIBacSub10457_3255.

Organism-specific databases

GenoListi BSU31140. [Micado ]

Phylogenomic databases

eggNOGi NOG236067.
HOGENOMi HOG000080196.
InParanoidi O32085.
OMAi CILIVNG.
OrthoDBi EOG67X1TS.
PhylomeDBi O32085.

Enzyme and pathway databases

BioCyci BSUB:BSU31140-MONOMER.
BRENDAi 1.13.11.20. 700.
SABIO-RK O32085.

Miscellaneous databases

EvolutionaryTracei O32085.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF05995. CDO_I. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  2. "Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria."
    Dominy J.E. Jr., Simmons C.R., Karplus P.A., Gehring A.M., Stipanuk M.H.
    J. Bacteriol. 188:5561-5569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCDOA_BACSU
AccessioniPrimary (citable) accession number: O32085
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3