O32085 (CDOA_BACSU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 65.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cysteine dioxygenase Short name=CDO EC=1.13.11.20 | ||||||
| Gene names |
| ||||||
| Organism | Bacillus subtilis | ||||||
| Taxonomic identifier | 1423 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 161 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | L-cysteine + O2 = 3-sulfinoalanine. Ref.2 |
| Cofactor | Binds 1 iron ion per subunit By similarity. |
| Developmental stage | Up-regulated upon sporulation. Ref.2 |
| Sequence similarities | Belongs to the cysteine dioxygenase family. |
| Biophysicochemical properties | Kinetic parameters: KM=3.0 mM for cysteine Ref.2 pH dependence: Optimum pH is 6.2. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | cysteine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 161 | 161 | Cysteine dioxygenase | PRO_0000360761 | |||||||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||||||||
| Metal binding | 75 | 1 | Iron; catalytic By similarity | ||||||||||||||||||||||||||||||
| Metal binding | 77 | 1 | Iron; catalytic By similarity | ||||||||||||||||||||||||||||||
| Metal binding | 125 | 1 | Iron; catalytic By similarity | ||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||
| Helix | 3 – 10 | 8 | |||||||||||||||||||||||||||||||
| Helix | 19 – 26 | 8 | |||||||||||||||||||||||||||||||
| Helix | 32 – 36 | 5 | |||||||||||||||||||||||||||||||
| Beta strand | 44 – 46 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 51 – 55 | 5 | |||||||||||||||||||||||||||||||
| Beta strand | 60 – 66 | 7 | |||||||||||||||||||||||||||||||
| Beta strand | 83 – 88 | 6 | |||||||||||||||||||||||||||||||
| Beta strand | 91 – 98 | 8 | |||||||||||||||||||||||||||||||
| Beta strand | 103 – 111 | 9 | |||||||||||||||||||||||||||||||
| Beta strand | 124 – 128 | 5 | |||||||||||||||||||||||||||||||
| Beta strand | 131 – 133 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 135 – 143 | 9 | |||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [2] | "Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria." Dominy J.E. Jr., Simmons C.R., Karplus P.A., Gehring A.M., Stipanuk M.H. J. Bacteriol. 188:5561-5569(2006) [PubMed: 16855246] [Abstract] Cited for: CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, DEVELOPMENTAL STAGE. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AL009126 Genomic DNA. Translation: CAB15092.1. | ||||||||||||
| PIR | F70006. | ||||||||||||
| RefSeq | NP_390992.1. NC_000964.3. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | O32085. | ||||||||||||
| SMR | O32085. Positions 1-154. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| EnsemblBacteria | EBBACT00000003406; EBBACP00000003406; EBBACG00000003399. | ||||||||||||
| GeneID | 938837. | ||||||||||||
| GenomeReviews | Gene locus BSU31140 in contig AL009126_GR. | ||||||||||||
| KEGG | bsu:BSU31140. | ||||||||||||
| NMPDR | fig|224308.1.peg.3117. | ||||||||||||
| PATRIC | 18978182. VBIBacSub10457_3255. | ||||||||||||
Organism-specific databases | |||||||||||||
| GenoList | BSU31140. [Micado] | ||||||||||||
Phylogenomic databases | |||||||||||||
| GeneTree | EBGT00050000005627. | ||||||||||||
| OMA | TEGNIFT. | ||||||||||||
| ProtClustDB | CLSK219258. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BioCyc | BSUB:BSU31140-MONOMER. | ||||||||||||
| BRENDA | 1.13.11.20. 700. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR011051. Cupin_RmlC_type. IPR010300. Cys_dOase_I. IPR014710. RmlC-like_jellyroll. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit. | ||||||||||||
| Pfam | PF05995. CDO_I. 1 hit. [Graphical view] | ||||||||||||
| SUPFAM | SSF51182. RmlC_like_cupin. 1 hit. | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Entry information
| Entry name | CDOA_BACSU | ||||||||
| Accession | Primary (citable) accession number: O32085 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with