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O32085 (CDOA_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine dioxygenase
Short name=CDO
EC=1.13.11.20
Gene names
Name:cdoA
Synonyms:yubC
Ordered Locus Names:BSU31140
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

L-cysteine + O2 = 3-sulfinoalanine. Ref.2

Cofactor

Binds 1 iron ion per subunit By similarity.

Developmental stage

Up-regulated upon sporulation. Ref.2

Sequence similarities

Belongs to the cysteine dioxygenase family.

Biophysicochemical properties

Kinetic parameters:

KM=3.0 mM for cysteine Ref.2

pH dependence:

Optimum pH is 6.2.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 161161Cysteine dioxygenase
PRO_0000360761

Sites

Metal binding751Iron; catalytic By similarity
Metal binding771Iron; catalytic By similarity
Metal binding1251Iron; catalytic By similarity

Secondary structure

1 ....................... 161
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O32085 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9580D43AE8AFE016

FASTA16118,127
        10         20         30         40         50         60 
MELYECIQDI FGGLKNPSVK DLATSLKQIP NAAKLSQPYI KEPDQYAYGR NAIYRNNELE 

        70         80         90        100        110        120 
IIVINIPPNK ETTVHDHGQS IGCAMVLEGK LLNSIYRSTG EHAELSNSYF VHEGECLIST 

       130        140        150        160 
KGLIHKMSNP TSERMVSLHV YSPPLEDMTV FEEQKEVLEN S

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[2]"Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria."
Dominy J.E. Jr., Simmons C.R., Karplus P.A., Gehring A.M., Stipanuk M.H.
J. Bacteriol. 188:5561-5569(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL009126 Genomic DNA. Translation: CAB15092.1.
PIRF70006.
RefSeqNP_390992.1. NC_000964.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3EQEX-ray2.82A/B1-161[»]
ProteinModelPortalO32085.
SMRO32085. Positions 1-154.
ModBaseSearch...

Protein-protein interaction databases

STRING224308.BSU31140.

Proteomic databases

PaxDbO32085.

Protocols and materials databases

DNASU938837.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB15092; CAB15092; BSU31140.
GeneID938837.
KEGGbsu:BSU31140.
PATRIC18978182. VBIBacSub10457_3255.

Organism-specific databases

GenoListBSU31140. [Micado]

Phylogenomic databases

eggNOGNOG236067.
HOGENOMHOG000080196.
OMAMELYECI.
ProtClustDBCLSK219258.

Enzyme and pathway databases

BioCycBSUB:BSU31140-MONOMER.
BRENDA1.13.11.20. 700.
SABIO-RKO32085.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMSSF51182. RmlC_like_cupin. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceO32085.

Entry information

Entry nameCDOA_BACSU
AccessionPrimary (citable) accession number: O32085
Entry history
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents