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Protein

Ktr system potassium uptake protein B

Gene

ktrB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integral membrane subunit of the KtrAB potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

BioCyciBSUB:BSU31100-MONOMER

Protein family/group databases

TCDBi2.A.38.4.3 the k(+) transporter (trk) family

Names & Taxonomyi

Protein namesi
Recommended name:
Ktr system potassium uptake protein B
Short name:
K(+)-uptake protein KtrB
Gene namesi
Name:ktrB
Synonyms:yubG
Ordered Locus Names:BSU31100
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Impaired potassium uptake.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi436 – 445Missing : Loss of homodimerization. 1 Publication10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003606181 – 445Ktr system potassium uptake protein BAdd BLAST445

Proteomic databases

PaxDbiO32081

Interactioni

Subunit structurei

Homodimer. Part of the KtrAB complex formed by an octameric catalytic ring of KtrA and a membrane associated dimer of KtrB forming a potassium channel.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ktrAO320802EBI-16045470,EBI-16045427

Protein-protein interaction databases

DIPiDIP-60210N
IntActiO32081, 1 interactor
STRINGi224308.Bsubs1_010100016911

Structurei

Secondary structure

1445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 36Combined sources21
Helixi38 – 40Combined sources3
Beta strandi41 – 43Combined sources3
Helixi47 – 58Combined sources12
Helixi68 – 71Combined sources4
Helixi74 – 89Combined sources16
Helixi91 – 101Combined sources11
Helixi108 – 117Combined sources10
Helixi126 – 145Combined sources20
Helixi148 – 151Combined sources4
Helixi161 – 173Combined sources13
Beta strandi180 – 185Combined sources6
Helixi186 – 188Combined sources3
Helixi192 – 206Combined sources15
Helixi209 – 218Combined sources10
Beta strandi220 – 223Combined sources4
Helixi226 – 250Combined sources25
Helixi254 – 258Combined sources5
Helixi264 – 274Combined sources11
Turni275 – 279Combined sources5
Helixi291 – 302Combined sources12
Beta strandi307 – 310Combined sources4
Helixi316 – 330Combined sources15
Helixi345 – 372Combined sources28
Helixi377 – 388Combined sources12
Helixi398 – 400Combined sources3
Helixi403 – 418Combined sources16
Helixi420 – 424Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J7CX-ray3.50I/J/K/L1-445[»]
5BUTX-ray5.97I/J/K/L1-445[»]
ProteinModelPortaliO32081
SMRiO32081
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CZN Bacteria
COG0168 LUCA
HOGENOMiHOG000277617
InParanoidiO32081
KOiK03498
OMAiAYMLARP
PhylomeDBiO32081

Family and domain databases

InterProiView protein in InterPro
IPR003445 Cat_transpt
IPR004772 TrkH
PfamiView protein in Pfam
PF02386 TrkH, 1 hit
TIGRFAMsiTIGR00933 2a38, 1 hit

Sequencei

Sequence statusi: Complete.

O32081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLQKDKVIK WVRFTPPQVL AIGFFLTIII GAVLLMLPIS TTKPLSWIDA
60 70 80 90 100
LFTAASATTV TGLAVVDTGT QFTVFGQTVI MGLIQIGGLG FMTFAVLIVM
110 120 130 140 150
ILGKKIGLKE RMLVQEALNQ PTIGGVIGLV KVLFLFSISI ELIAALILSI
160 170 180 190 200
RLVPQYGWSS GLFASLFHAI SAFNNAGFSL WPDNLMSYVG DPTVNLVITF
210 220 230 240 250
LFITGGIGFT VLFDVMKNRR FKTFSLHTKL MLTGTLMLNA IAMLTVFILE
260 270 280 290 300
YSNPGTLGHL HIVDKLWASY FQAVTPRTAG FNSLDFGSMR EGTIVFTLLL
310 320 330 340 350
MFIGAGSAST ASGIKLTTFI VILTSVIAYL RGKKETVIFR RSIKYPIIIK
360 370 380 390 400
ALAVSVTSLF IVFLGIFALT ITEQAPFLQI VFETFSAFGT VGLTMGLTPE
410 420 430 440
LTTAGKCIII VIMFIGRIGP LTFVFSFAKT EQSNIRYPDG EVFTG
Length:445
Mass (Da):48,437
Last modified:January 1, 1998 - v1
Checksum:i94AFD060587FD117
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB15088.1
PIRiB70007
RefSeqiNP_390988.1, NC_000964.3
WP_003243582.1, NZ_JNCM01000033.1

Genome annotation databases

EnsemblBacteriaiCAB15088; CAB15088; BSU31100
GeneIDi938835
KEGGibsu:BSU31100
PATRICifig|224308.179.peg.3370

Similar proteinsi

Entry informationi

Entry nameiKTRB_BACSU
AccessioniPrimary (citable) accession number: O32081
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health