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Protein

Ktr system potassium uptake protein A

Gene

ktrA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic subunit of the KtrAB potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei16NAD2 Publications1
Binding sitei109NAD2 Publications1
Binding sitei125NAD2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 38NAD2 Publications3
Nucleotide bindingi56 – 57NAD2 Publications2
Nucleotide bindingi78 – 80NAD2 Publications3
Nucleotide bindingi103 – 105NAD2 Publications3

GO - Molecular functioni

  • cation transmembrane transporter activity Source: InterPro
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Transport
LigandNAD, Potassium

Enzyme and pathway databases

BioCyciBSUB:BSU31090-MONOMER

Protein family/group databases

TCDBi2.A.38.4.3 the k(+) transporter (trk) family

Names & Taxonomyi

Protein namesi
Recommended name:
Ktr system potassium uptake protein A
Short name:
K(+)-uptake protein KtrA
Gene namesi
Name:ktrA
Synonyms:yuaA
Ordered Locus Names:BSU31090
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Impaired potassium uptake.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003606191 – 222Ktr system potassium uptake protein AAdd BLAST222

Proteomic databases

PaxDbiO32080
PRIDEiO32080

Interactioni

Subunit structurei

Homodimer, tetramer (dimer of homodimer) and octamer (tetramer of homodimer). Part of the KtrAB complex formed by an octameric catalytic ring of KtrA and a membrane associated dimer of KtrB forming a potassium channel.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-60209N
IntActiO32080, 1 interactor
STRINGi224308.Bsubs1_010100016906

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Helixi16 – 27Combined sources12
Beta strandi33 – 37Combined sources5
Helixi39 – 43Combined sources5
Turni44 – 48Combined sources5
Beta strandi50 – 54Combined sources5
Helixi60 – 64Combined sources5
Turni65 – 67Combined sources3
Helixi68 – 70Combined sources3
Beta strandi72 – 76Combined sources5
Helixi82 – 94Combined sources13
Beta strandi98 – 103Combined sources6
Helixi107 – 116Combined sources10
Beta strandi119 – 122Combined sources4
Helixi124 – 140Combined sources17
Turni141 – 143Combined sources3
Beta strandi148 – 151Combined sources4
Beta strandi153 – 156Combined sources4
Helixi160 – 162Combined sources3
Turni167 – 169Combined sources3
Helixi172 – 175Combined sources4
Beta strandi179 – 185Combined sources7
Beta strandi188 – 192Combined sources5
Beta strandi205 – 209Combined sources5
Helixi211 – 221Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LSUX-ray2.85A/B1-143[»]
2HMSX-ray2.70A/B/C/D1-144[»]
2HMTX-ray2.20A/B1-144[»]
2HMUX-ray2.25A/B1-144[»]
2HMVX-ray2.20A/B1-144[»]
2HMWX-ray3.00A/B1-144[»]
4J7CX-ray3.50A/B/C/D/E/F/G/H1-222[»]
4J90X-ray3.24A/B1-222[»]
4J91X-ray2.93A/B/C/D1-222[»]
5BUTX-ray5.97A/C/E/G1-212[»]
ProteinModelPortaliO32080
SMRiO32080
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO32080

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 130RCK N-terminalPROSITE-ProRule annotationAdd BLAST123
Domaini139 – 222RCK C-terminalPROSITE-ProRule annotationAdd BLAST84

Sequence similaritiesi

Belongs to the KtrA potassium transport family.Curated

Phylogenomic databases

eggNOGiCOG0569 LUCA
HOGENOMiHOG000279860
InParanoidiO32080
KOiK03499
OMAiAIGANIQ
PhylomeDBiO32080

Family and domain databases

Gene3Di3.30.70.1450, 1 hit
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR006037 RCK_C
IPR036721 RCK_C_sf
IPR003148 RCK_N
PfamiView protein in Pfam
PF02080 TrkA_C, 1 hit
PF02254 TrkA_N, 1 hit
SUPFAMiSSF116726 SSF116726, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS51202 RCK_C, 1 hit
PS51201 RCK_N, 1 hit

Sequencei

Sequence statusi: Complete.

O32080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRIKNKQFA VIGLGRFGGS ICKELHRMGH EVLAVDINEE KVNAYASYAT
60 70 80 90 100
HAVIANATEE NELLSLGIRN FEYVIVAIGA NIQASTLTTL LLKELDIPNI
110 120 130 140 150
WVKAQNYYHH KVLEKIGADR IIHPEKDMGV KIAQSLSDEN VLNYIDLSDE
160 170 180 190 200
YSIVELLATR KLDSKSIIDL NVRAKYGCTI LAIKHHGDIC LSPAPEDIIR
210 220
EQDCLVIMGH KKDIKRFENE GM
Length:222
Mass (Da):24,882
Last modified:January 1, 1998 - v1
Checksum:i24E32EDB155E806F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB15087.1
PIRiC70005
RefSeqiNP_390987.1, NC_000964.3
WP_003243377.1, NZ_JNCM01000033.1

Genome annotation databases

EnsemblBacteriaiCAB15087; CAB15087; BSU31090
GeneIDi937145
KEGGibsu:BSU31090
PATRICifig|224308.179.peg.3369

Similar proteinsi

Entry informationi

Entry nameiKTRA_BACSU
AccessioniPrimary (citable) accession number: O32080
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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