O32057 (YRZF_BACSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative serine/threonine-protein kinase YrzF
EC=2.7.11.1

Gene names

Name:	yrzF
Ordered Locus Names:	BSU27785
ORF Names:	BSU27780

Organism

Bacillus subtilis (strain 168) [Reference proteome] [HAMAP]

Taxonomic identifier

224308 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus subtilis group › Bacillus subtilis › Bacillus subtilis subsp. subtilis

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.
Sequence caution	The sequence CAB75326.1 differs from that shown. Reason: Frameshift at position 127.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	Putative serine/threonine-protein kinase YrzF		PRO_0000387941
Regions
	Domain	27 – 215	189	Protein kinase
	Nucleotide binding	33 – 41	9	ATP By similarity
Sites
	Active site	135	1	Proton acceptor By similarity
	Binding site	54	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	O32057 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 9C019DDEFE44490F	FASTA	215	24,720
	10 20 30 40 50 60 MLTKAEALAH TVIYRKNSRF DKVKEKSEEL TLIGKGRSAY VFALTEGGRK MALKVFFPEY 70 80 90 100 110 120 QATAVKEAAI YEKLAGSAFY PDIYETGDSF ILMEYIKGET FYNCLKKGIA ISDDMIQQVE 130 140 150 160 170 180 EALSDARAAG LNPSDIHLRN LILTETGAVR VIDVARFEQT KTCTQWDDLK SAYHALYKKP 190 200 210 IFPKKIPGFW LEIIAFLYKK DWFQKHFAQR KRKYS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 17.8 kb segment in the spoVB-nadC region of the Bacillus subtilis 168 chromosome: sequencing and ruv operon identification." Tosato V., Bolotin A., Bertani I., Valentino I., Bruschi C.V. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[3]	"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later." Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A. Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION TO C-TERMINUS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y15896 Genomic DNA. Translation: CAB75326.1. Frameshift. AL009126 Genomic DNA. Translation: CAB14738.2.
PIR	E69982.
RefSeq	NP_390656.2. NC_000964.3.
3D structure databases
ProteinModelPortal	O32057.
SMR	O32057. Positions 24-205.
ModBase	Search...
Protein-protein interaction databases
STRING	224308.BSU27785.
Proteomic databases
PaxDb	O32057.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB14738; CAB14738; BSU27785.
GeneID	936570.
KEGG	bsu:BSU27785.
PATRIC	18977424. VBIBacSub10457_2901.
Organism-specific databases
GenoList	BSU27785.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000011094.
ProtClustDB	CLSK904680.
Enzyme and pathway databases
BioCyc	BSUB:BSU27785-MONOMER.
Family and domain databases
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR011009. Kinase-like_dom. IPR017441. Protein_kinase_ATP_BS. [Graphical view]
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. False negative. PS00108. PROTEIN_KINASE_ST. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YRZF_BACSU

Accession

Primary (citable) accession number: O32057
Secondary accession number(s): C0SPA9, Q799D9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program