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O32039

- SYH_BACSU

UniProt

O32039 - SYH_BACSU

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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histidine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU27560-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligase (EC:6.1.1.21)
Alternative name(s):
Histidyl-tRNA synthetase
Short name:
HisRS
Gene namesi
Name:hisS
Ordered Locus Names:BSU27560
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU27560. [Micado]

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Histidine--tRNA ligasePRO_0000136105Add
BLAST

Proteomic databases

PaxDbiO32039.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiO32039. 1 interaction.
MINTiMINT-8365629.
STRINGi224308.BSU27560.

Structurei

3D structure databases

ProteinModelPortaliO32039.
SMRiO32039. Positions 3-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018072.
InParanoidiO32039.
KOiK01892.
OMAiCGGGNFK.
OrthoDBiEOG6BPDH4.
PhylomeDBiO32039.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O32039-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGYNIPRGTQ DILPGESDRW QFVEQIMRDT CRTYQYKEIR TPIFEHTELF
60 70 80 90 100
ARGVGESTDI VQKEMYTFED RKGRSLTLRP EGTAAAVRAF NENKLFANPV
110 120 130 140 150
QPTKLYYVGP MFRYERPQTG RYRQFYQFGI EAIGSKDPAI DAEVMALAMS
160 170 180 190 200
IYEKAGLENV KLVINSLGDQ DSRKSYREAL VKHFEPRIEE FCSDCQSRLH
210 220 230 240 250
TNPLRILDCK KDRDHELMKS APSILTYLNE ESAAYFEKVK QYLNDLGISY
260 270 280 290 300
EIDPNLVRGL DYYNHTAFEI MSNAEGFGAI TTLAGGGRYD GLVEQIGGPE
310 320 330 340 350
APGIGFAMSI ERLLAAIDAE KRELPVDKGI DCYIVTLGEK AKDYSVSLVY
360 370 380 390 400
KLREAGISSE IDYENKKMKG QFKTADRLKA RFIAILGEDE LAQNKINVKD
410 420
AQTGEQIEVA LDEFIHVMKA NQKG
Length:424
Mass (Da):48,132
Last modified:January 1, 1998 - v1
Checksum:i2FF1FC001684C87D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB14715.1.
PIRiG69641.
RefSeqiNP_390634.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB14715; CAB14715; BSU27560.
GeneIDi938617.
KEGGibsu:BSU27560.
PATRICi18977376. VBIBacSub10457_2877.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB14715.1 .
PIRi G69641.
RefSeqi NP_390634.1. NC_000964.3.

3D structure databases

ProteinModelPortali O32039.
SMRi O32039. Positions 3-420.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O32039. 1 interaction.
MINTi MINT-8365629.
STRINGi 224308.BSU27560.

Proteomic databases

PaxDbi O32039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB14715 ; CAB14715 ; BSU27560 .
GeneIDi 938617.
KEGGi bsu:BSU27560.
PATRICi 18977376. VBIBacSub10457_2877.

Organism-specific databases

GenoListi BSU27560. [Micado ]

Phylogenomic databases

eggNOGi COG0124.
HOGENOMi HOG000018072.
InParanoidi O32039.
KOi K01892.
OMAi CGGGNFK.
OrthoDBi EOG6BPDH4.
PhylomeDBi O32039.

Enzyme and pathway databases

BioCyci BSUB:BSU27560-MONOMER.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
HAMAPi MF_00127. His_tRNA_synth.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view ]
PANTHERi PTHR11476. PTHR11476. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view ]
PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMi SSF52954. SSF52954. 1 hit.
TIGRFAMsi TIGR00442. hisS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.

Entry informationi

Entry nameiSYH_BACSU
AccessioniPrimary (citable) accession number: O32039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3