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O31982

- BLYA_BACSU

UniProt

O31982 - BLYA_BACSU

Protein

N-acetylmuramoyl-L-alanine amidase BlyA

Gene

blyA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Involved in prophage SP-beta-mediated cell lysis.1 Publication

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. establishment of competence for transformation Source: UniProtKB-KW
    2. peptidoglycan catabolic process Source: InterPro
    3. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cell wall biogenesis/degradation, Competence, Sporulation

    Enzyme and pathway databases

    BioCyciBSUB:BSU21410-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetylmuramoyl-L-alanine amidase BlyA (EC:3.5.1.28)
    Alternative name(s):
    Autolysin
    Cell wall hydrolase
    Gene namesi
    Name:blyA
    Synonyms:yomC
    Ordered Locus Names:BSU21410
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU21410. [Micado]

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367N-acetylmuramoyl-L-alanine amidase BlyAPRO_0000164416Add
    BLAST

    Proteomic databases

    PaxDbiO31982.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU21410.

    Structurei

    3D structure databases

    ProteinModelPortaliO31982.
    SMRiO31982. Positions 1-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5632.
    HOGENOMiHOG000095240.
    KOiK01447.
    OMAiEHTIPIN.
    OrthoDBiEOG6GR386.

    Family and domain databases

    Gene3Di3.40.80.10. 1 hit.
    InterProiIPR002502. Amidase_domain.
    [Graphical view]
    PfamiPF01510. Amidase_2. 1 hit.
    [Graphical view]
    SMARTiSM00644. Ami_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55846. SSF55846. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O31982-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVFTNSYIP VNKYTRPGLK LQGVKKCVLH YTANPGAGAD NHRRYFSNAQ    50
    VYASAHIFVD KAEAICIIPL NEVAYHANDI QQRDSAGNPY RGVAALKPNA 100
    NFLSIGVEMC LEKDGSFHSD TVERTEDVFV ELCNKFGLDP IDDIVRHYDI 150
    THKNCPAPWV SNSQKFVDFK NRVKAKMSGK SVSKASPTKP TTSSPSSSSA 200
    VSGSLKSKVD GLRFYSKPSW EDKDVVGTVN KGIGFPTVVE KVKVGSAYQY 250
    KVKNSKGTTY YITASDKYVD VTGSVKTSSS APKTTSTSSS SSSIKSVGKI 300
    KIVGVSSAAI VMDKPDRNSS KNIGTVKLGS TISISGSVKG KNNSNGYWEV 350
    IYKGKRGYIS GQFGSTI 367
    Length:367
    Mass (Da):39,629
    Last modified:January 1, 1998 - v1
    Checksum:i20D8BA91DF6A982A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF021803 Genomic DNA. Translation: AAC38300.1.
    AL009126 Genomic DNA. Translation: CAB14059.1.
    RefSeqiNP_390024.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB14059; CAB14059; BSU21410.
    GeneIDi939130.
    KEGGibsu:BSU21410.
    PATRICi18976087. VBIBacSub10457_2234.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF021803 Genomic DNA. Translation: AAC38300.1 .
    AL009126 Genomic DNA. Translation: CAB14059.1 .
    RefSeqi NP_390024.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali O31982.
    SMRi O31982. Positions 1-173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU21410.

    Proteomic databases

    PaxDbi O31982.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB14059 ; CAB14059 ; BSU21410 .
    GeneIDi 939130.
    KEGGi bsu:BSU21410.
    PATRICi 18976087. VBIBacSub10457_2234.

    Organism-specific databases

    GenoListi BSU21410. [Micado ]

    Phylogenomic databases

    eggNOGi COG5632.
    HOGENOMi HOG000095240.
    KOi K01447.
    OMAi EHTIPIN.
    OrthoDBi EOG6GR386.

    Enzyme and pathway databases

    BioCyci BSUB:BSU21410-MONOMER.

    Family and domain databases

    Gene3Di 3.40.80.10. 1 hit.
    InterProi IPR002502. Amidase_domain.
    [Graphical view ]
    Pfami PF01510. Amidase_2. 1 hit.
    [Graphical view ]
    SMARTi SM00644. Ami_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55846. SSF55846. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The N-acetylmuramoyl-L-alanine amidase encoded by the Bacillus subtilis 168 prophage SP beta."
      Regamey A., Karamata D.
      Microbiology 144:885-893(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.

    Entry informationi

    Entry nameiBLYA_BACSU
    AccessioniPrimary (citable) accession number: O31982
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3