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O31982 (BLYA_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetylmuramoyl-L-alanine amidase BlyA

EC=3.5.1.28
Alternative name(s):
Autolysin
Cell wall hydrolase
Gene names
Name:blyA
Synonyms:yomC
Ordered Locus Names:BSU21410
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Involved in prophage SP-beta-mediated cell lysis. Ref.1

Catalytic activity

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367N-acetylmuramoyl-L-alanine amidase BlyA
PRO_0000164416

Sequences

Sequence LengthMass (Da)Tools
O31982 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 20D8BA91DF6A982A

FASTA36739,629
        10         20         30         40         50         60 
MSVFTNSYIP VNKYTRPGLK LQGVKKCVLH YTANPGAGAD NHRRYFSNAQ VYASAHIFVD 

        70         80         90        100        110        120 
KAEAICIIPL NEVAYHANDI QQRDSAGNPY RGVAALKPNA NFLSIGVEMC LEKDGSFHSD 

       130        140        150        160        170        180 
TVERTEDVFV ELCNKFGLDP IDDIVRHYDI THKNCPAPWV SNSQKFVDFK NRVKAKMSGK 

       190        200        210        220        230        240 
SVSKASPTKP TTSSPSSSSA VSGSLKSKVD GLRFYSKPSW EDKDVVGTVN KGIGFPTVVE 

       250        260        270        280        290        300 
KVKVGSAYQY KVKNSKGTTY YITASDKYVD VTGSVKTSSS APKTTSTSSS SSSIKSVGKI 

       310        320        330        340        350        360 
KIVGVSSAAI VMDKPDRNSS KNIGTVKLGS TISISGSVKG KNNSNGYWEV IYKGKRGYIS 


GQFGSTI 

« Hide

References

« Hide 'large scale' references
[1]"The N-acetylmuramoyl-L-alanine amidase encoded by the Bacillus subtilis 168 prophage SP beta."
Regamey A., Karamata D.
Microbiology 144:885-893(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF021803 Genomic DNA. Translation: AAC38300.1.
AL009126 Genomic DNA. Translation: CAB14059.1.
RefSeqNP_390024.1. NC_000964.3.

3D structure databases

ProteinModelPortalO31982.
SMRO31982. Positions 1-173.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU21410.

Proteomic databases

PaxDbO31982.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB14059; CAB14059; BSU21410.
GeneID939130.
KEGGbsu:BSU21410.
PATRIC18976087. VBIBacSub10457_2234.

Organism-specific databases

GenoListBSU21410. [Micado]

Phylogenomic databases

eggNOGCOG5632.
HOGENOMHOG000095240.
KOK01447.
OMAEHTIPIN.
OrthoDBEOG6GR386.

Enzyme and pathway databases

BioCycBSUB:BSU21410-MONOMER.

Family and domain databases

Gene3D3.40.80.10. 1 hit.
InterProIPR002502. Amidase_domain.
[Graphical view]
PfamPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTSM00644. Ami_2. 1 hit.
[Graphical view]
SUPFAMSSF55846. SSF55846. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBLYA_BACSU
AccessionPrimary (citable) accession number: O31982
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList