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Protein

N-acetylmuramoyl-L-alanine amidase BlyA

Gene

blyA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Involved in prophage SP-beta-mediated cell lysis.1 Publication

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCell wall biogenesis/degradation, Competence, Sporulation

Enzyme and pathway databases

BioCyciBSUB:BSU21410-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase BlyA (EC:3.5.1.28)
Alternative name(s):
Autolysin
Cell wall hydrolase
Gene namesi
Name:blyA
Synonyms:yomC
Ordered Locus Names:BSU21410
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001644161 – 367N-acetylmuramoyl-L-alanine amidase BlyAAdd BLAST367

Proteomic databases

PaxDbiO31982
PRIDEiO31982

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100011791

Structurei

3D structure databases

ProteinModelPortaliO31982
SMRiO31982
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 271SH3b 1PROSITE-ProRule annotationAdd BLAST70
Domaini298 – 367SH3b 2PROSITE-ProRule annotationAdd BLAST70

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108VPC Bacteria
COG5632 LUCA
HOGENOMiHOG000095240
KOiK01447
OMAiVNKYTRP

Family and domain databases

CDDicd06583 PGRP, 1 hit
Gene3Di3.40.80.10, 1 hit
InterProiView protein in InterPro
IPR036505 Amidase/PGRP_sf
IPR002502 Amidase_domain
IPR003646 SH3-like_bac-type
PfamiView protein in Pfam
PF01510 Amidase_2, 1 hit
SMARTiView protein in SMART
SM00644 Ami_2, 1 hit
SUPFAMiSSF55846 SSF55846, 1 hit
PROSITEiView protein in PROSITE
PS51781 SH3B, 2 hits

Sequencei

Sequence statusi: Complete.

O31982-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVFTNSYIP VNKYTRPGLK LQGVKKCVLH YTANPGAGAD NHRRYFSNAQ
60 70 80 90 100
VYASAHIFVD KAEAICIIPL NEVAYHANDI QQRDSAGNPY RGVAALKPNA
110 120 130 140 150
NFLSIGVEMC LEKDGSFHSD TVERTEDVFV ELCNKFGLDP IDDIVRHYDI
160 170 180 190 200
THKNCPAPWV SNSQKFVDFK NRVKAKMSGK SVSKASPTKP TTSSPSSSSA
210 220 230 240 250
VSGSLKSKVD GLRFYSKPSW EDKDVVGTVN KGIGFPTVVE KVKVGSAYQY
260 270 280 290 300
KVKNSKGTTY YITASDKYVD VTGSVKTSSS APKTTSTSSS SSSIKSVGKI
310 320 330 340 350
KIVGVSSAAI VMDKPDRNSS KNIGTVKLGS TISISGSVKG KNNSNGYWEV
360
IYKGKRGYIS GQFGSTI
Length:367
Mass (Da):39,629
Last modified:January 1, 1998 - v1
Checksum:i20D8BA91DF6A982A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021803 Genomic DNA Translation: AAC38300.1
AL009126 Genomic DNA Translation: CAB14059.1
RefSeqiNP_390024.1, NC_000964.3
WP_004399108.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14059; CAB14059; BSU21410
GeneIDi939130
KEGGibsu:BSU21410
PATRICifig|224308.179.peg.2338

Similar proteinsi

Entry informationi

Entry nameiBLYA_BACSU
AccessioniPrimary (citable) accession number: O31982
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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