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Protein

HTH-type transcriptional repressor CzrA

Gene

czrA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90ZincPROSITE-ProRule annotation1
Metal bindingi92ZincPROSITE-ProRule annotation1
Metal bindingi103ZincPROSITE-ProRule annotation1
Metal bindingi106ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi48 – 71H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBSUB:BSU19120-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor CzrA
Gene namesi
Name:czrA
Synonyms:yozA
Ordered Locus Names:BSU19120
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003784721 – 107HTH-type transcriptional repressor CzrAAdd BLAST107

Proteomic databases

PaxDbiO31844.
PRIDEiO31844.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100010556.

Structurei

3D structure databases

ProteinModelPortaliO31844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 107HTH arsR-typePROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105KTU. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiO31844.
OMAiMIHHTRH.
PhylomeDBiO31844.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O31844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFRETEQS AADLDEETLF LVAQTFKALS DPTRIRILHL LSQGEHAVNG
60 70 80 90 100
IAEKLNLLQS TVSHQLRFLK NLRLVKSRRE GTSIYYSPED EHVLDVLQQM

IHHTQHD
Length:107
Mass (Da):12,379
Last modified:January 1, 1998 - v1
Checksum:i1F5D693B9DBF0ABB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB13804.1.
PIRiE69930.
RefSeqiNP_389793.1. NC_000964.3.
WP_003231284.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB13804; CAB13804; BSU19120.
GeneIDi939658.
KEGGibsu:BSU19120.
PATRICi18975671. VBIBacSub10457_2026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB13804.1.
PIRiE69930.
RefSeqiNP_389793.1. NC_000964.3.
WP_003231284.1. NZ_JNCM01000036.1.

3D structure databases

ProteinModelPortaliO31844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100010556.

Proteomic databases

PaxDbiO31844.
PRIDEiO31844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13804; CAB13804; BSU19120.
GeneIDi939658.
KEGGibsu:BSU19120.
PATRICi18975671. VBIBacSub10457_2026.

Phylogenomic databases

eggNOGiENOG4105KTU. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiO31844.
OMAiMIHHTRH.
PhylomeDBiO31844.

Enzyme and pathway databases

BioCyciBSUB:BSU19120-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCZRA_BACSU
AccessioniPrimary (citable) accession number: O31844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Can bind copper. It does not affect DNA binding but it inhibits zinc-mediated regulation.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.