Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HTH-type transcriptional repressor CzrA

Gene

czrA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA.1 Publication

Miscellaneous

Can bind copper. It does not affect DNA binding but it inhibits zinc-mediated regulation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90ZincPROSITE-ProRule annotation1
Metal bindingi92ZincPROSITE-ProRule annotation1
Metal bindingi103ZincPROSITE-ProRule annotation1
Metal bindingi106ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi48 – 71H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciBSUB:BSU19120-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor CzrA
Gene namesi
Name:czrA
Synonyms:yozA
Ordered Locus Names:BSU19120
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003784721 – 107HTH-type transcriptional repressor CzrAAdd BLAST107

Proteomic databases

PaxDbiO31844.
PRIDEiO31844.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100010556.

Structurei

3D structure databases

ProteinModelPortaliO31844.
SMRiO31844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 107HTH arsR-typePROSITE-ProRule annotationAdd BLAST94

Phylogenomic databases

eggNOGiENOG4105KTU. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiO31844.
OMAiMIHHTRH.
PhylomeDBiO31844.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01022. HTH_5. 1 hit.
PRINTSiPR00778. HTHARSR.
SMARTiView protein in SMART
SM00418. HTH_ARSR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50987. HTH_ARSR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O31844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFRETEQS AADLDEETLF LVAQTFKALS DPTRIRILHL LSQGEHAVNG
60 70 80 90 100
IAEKLNLLQS TVSHQLRFLK NLRLVKSRRE GTSIYYSPED EHVLDVLQQM

IHHTQHD
Length:107
Mass (Da):12,379
Last modified:January 1, 1998 - v1
Checksum:i1F5D693B9DBF0ABB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB13804.1.
PIRiE69930.
RefSeqiNP_389793.1. NC_000964.3.
WP_003231284.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB13804; CAB13804; BSU19120.
GeneIDi939658.
KEGGibsu:BSU19120.
PATRICi18975671. VBIBacSub10457_2026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB13804.1.
PIRiE69930.
RefSeqiNP_389793.1. NC_000964.3.
WP_003231284.1. NZ_JNCM01000036.1.

3D structure databases

ProteinModelPortaliO31844.
SMRiO31844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100010556.

Proteomic databases

PaxDbiO31844.
PRIDEiO31844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13804; CAB13804; BSU19120.
GeneIDi939658.
KEGGibsu:BSU19120.
PATRICi18975671. VBIBacSub10457_2026.

Phylogenomic databases

eggNOGiENOG4105KTU. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiO31844.
OMAiMIHHTRH.
PhylomeDBiO31844.

Enzyme and pathway databases

BioCyciBSUB:BSU19120-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01022. HTH_5. 1 hit.
PRINTSiPR00778. HTHARSR.
SMARTiView protein in SMART
SM00418. HTH_ARSR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50987. HTH_ARSR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCZRA_BACSU
AccessioniPrimary (citable) accession number: O31844
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: January 1, 1998
Last modified: March 15, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.