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Protein

Polyketide biosynthesis cytochrome P450 PksS

Gene

pksS

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the metabolism of the antibiotic polyketide bacillaene which is involved in secondary metabolism. The substrate is dihydrobacillaene.1 Publication

Pathwayi: bacillaene biosynthesis

This protein is involved in the pathway bacillaene biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bacillaene biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi352Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processAntibiotic biosynthesis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU17230-MONOMER
UniPathwayiUPA01003

Names & Taxonomyi

Protein namesi
Recommended name:
Polyketide biosynthesis cytochrome P450 PksS (EC:1.14.-.-)
Gene namesi
Name:pksS
Ordered Locus Names:BSU17230
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003807081 – 405Polyketide biosynthesis cytochrome P450 PksSAdd BLAST405

Proteomic databases

PaxDbiO31785
PRIDEiO31785

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100009476

Structurei

Secondary structure

1405
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 15Combined sources5
Helixi17 – 27Combined sources11
Beta strandi29 – 35Combined sources7
Beta strandi42 – 47Combined sources6
Helixi50 – 58Combined sources9
Beta strandi62 – 64Combined sources3
Helixi66 – 69Combined sources4
Helixi85 – 88Combined sources4
Helixi91 – 93Combined sources3
Helixi98 – 106Combined sources9
Helixi107 – 110Combined sources4
Helixi112 – 116Combined sources5
Helixi119 – 133Combined sources15
Beta strandi136 – 140Combined sources5
Helixi141 – 144Combined sources4
Turni145 – 147Combined sources3
Helixi148 – 158Combined sources11
Helixi162 – 164Combined sources3
Helixi165 – 175Combined sources11
Helixi180 – 182Combined sources3
Helixi183 – 206Combined sources24
Helixi212 – 218Combined sources7
Helixi228 – 259Combined sources32
Helixi261 – 269Combined sources9
Helixi271 – 273Combined sources3
Helixi274 – 285Combined sources12
Beta strandi295 – 298Combined sources4
Beta strandi300 – 302Combined sources3
Beta strandi305 – 307Combined sources3
Beta strandi312 – 315Combined sources4
Helixi317 – 320Combined sources4
Turni324 – 326Combined sources3
Beta strandi327 – 329Combined sources3
Helixi355 – 372Combined sources18
Helixi382 – 384Combined sources3
Beta strandi391 – 393Combined sources3
Beta strandi400 – 402Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YZRX-ray1.35A1-405[»]
ProteinModelPortaliO31785
SMRiO31785
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106A3M Bacteria
COG2124 LUCA
HOGENOMiHOG000243678
InParanoidiO31785
KOiK15468
OMAiNCIFLLN
PhylomeDBiO31785

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR002397 Cyt_P450_B
IPR017972 Cyt_P450_CS
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00359 BP450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

O31785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLMFHPHG KEFHHNPFSV LGRFREEEPI HRFELKRFGA TYPAWLITRY
60 70 80 90 100
DDCMAFLKDN RITRDVKNVM NQEQIKMLNV SEDIDFVSDH MLAKDTPDHT
110 120 130 140 150
RLRSLVHQAF TPRTIENLRG SIEQIAEQLL DEMEKENKAD IMKSFASPLP
160 170 180 190 200
FIVISELMGI PKEDRSQFQI WTNAMVDTSE GNRELTNQAL REFKDYIAKL
210 220 230 240 250
IHDRRIKPKD DLISKLVHAE ENGSKLSEKE LYSMLFLLVV AGLETTVNLL
260 270 280 290 300
GSGTLALLQH KKECEKLKQQ PEMIATAVEE LLRYTSPVVM MANRWAIEDF
310 320 330 340 350
TYKGHSIKRG DMIFIGIGSA NRDPNFFENP EILNINRSPN RHISFGFGIH
360 370 380 390 400
FCLGAPLARL EGHIAFKALL KRFPDIELAV APDDIQWRKN VFLRGLESLP

VSLSK
Length:405
Mass (Da):46,729
Last modified:May 5, 2009 - v2
Checksum:i99AD907CC96DD161
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB13607.2
RefSeqiNP_389605.2, NC_000964.3
WP_003244857.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13607; CAB13607; BSU17230
GeneIDi940046
KEGGibsu:BSU17230
PATRICifig|224308.179.peg.1868

Similar proteinsi

Entry informationi

Entry nameiPKSS_BACSU
AccessioniPrimary (citable) accession number: O31785
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: March 28, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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