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Protein

Polyketide biosynthesis cytochrome P450 PksS

Gene

pksS

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the metabolism of the antibiotic polyketide bacillaene which is involved in secondary metabolism. The substrate is dihydrobacillaene.1 Publication

Pathwayi: bacillaene biosynthesis

This protein is involved in the pathway bacillaene biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bacillaene biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi352Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Antibiotic biosynthesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU17230-MONOMER.
UniPathwayiUPA01003.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyketide biosynthesis cytochrome P450 PksS (EC:1.14.-.-)
Gene namesi
Name:pksS
Ordered Locus Names:BSU17230
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003807081 – 405Polyketide biosynthesis cytochrome P450 PksSAdd BLAST405

Proteomic databases

PaxDbiO31785.
PRIDEiO31785.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100009476.

Structurei

Secondary structure

1405
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 15Combined sources5
Helixi17 – 27Combined sources11
Beta strandi29 – 35Combined sources7
Beta strandi42 – 47Combined sources6
Helixi50 – 58Combined sources9
Beta strandi62 – 64Combined sources3
Helixi66 – 69Combined sources4
Helixi85 – 88Combined sources4
Helixi91 – 93Combined sources3
Helixi98 – 106Combined sources9
Helixi107 – 110Combined sources4
Helixi112 – 116Combined sources5
Helixi119 – 133Combined sources15
Beta strandi136 – 140Combined sources5
Helixi141 – 144Combined sources4
Turni145 – 147Combined sources3
Helixi148 – 158Combined sources11
Helixi162 – 164Combined sources3
Helixi165 – 175Combined sources11
Helixi180 – 182Combined sources3
Helixi183 – 206Combined sources24
Helixi212 – 218Combined sources7
Helixi228 – 259Combined sources32
Helixi261 – 269Combined sources9
Helixi271 – 273Combined sources3
Helixi274 – 285Combined sources12
Beta strandi295 – 298Combined sources4
Beta strandi300 – 302Combined sources3
Beta strandi305 – 307Combined sources3
Beta strandi312 – 315Combined sources4
Helixi317 – 320Combined sources4
Turni324 – 326Combined sources3
Beta strandi327 – 329Combined sources3
Helixi355 – 372Combined sources18
Helixi382 – 384Combined sources3
Beta strandi391 – 393Combined sources3
Beta strandi400 – 402Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YZRX-ray1.35A1-405[»]
ProteinModelPortaliO31785.
SMRiO31785.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106A3M. Bacteria.
COG2124. LUCA.
HOGENOMiHOG000243678.
InParanoidiO31785.
KOiK15468.
OMAiNKADIMK.
PhylomeDBiO31785.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O31785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLMFHPHG KEFHHNPFSV LGRFREEEPI HRFELKRFGA TYPAWLITRY
60 70 80 90 100
DDCMAFLKDN RITRDVKNVM NQEQIKMLNV SEDIDFVSDH MLAKDTPDHT
110 120 130 140 150
RLRSLVHQAF TPRTIENLRG SIEQIAEQLL DEMEKENKAD IMKSFASPLP
160 170 180 190 200
FIVISELMGI PKEDRSQFQI WTNAMVDTSE GNRELTNQAL REFKDYIAKL
210 220 230 240 250
IHDRRIKPKD DLISKLVHAE ENGSKLSEKE LYSMLFLLVV AGLETTVNLL
260 270 280 290 300
GSGTLALLQH KKECEKLKQQ PEMIATAVEE LLRYTSPVVM MANRWAIEDF
310 320 330 340 350
TYKGHSIKRG DMIFIGIGSA NRDPNFFENP EILNINRSPN RHISFGFGIH
360 370 380 390 400
FCLGAPLARL EGHIAFKALL KRFPDIELAV APDDIQWRKN VFLRGLESLP

VSLSK
Length:405
Mass (Da):46,729
Last modified:May 5, 2009 - v2
Checksum:i99AD907CC96DD161
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB13607.2.
RefSeqiNP_389605.2. NC_000964.3.
WP_003244857.1. NZ_JNCM01000035.1.

Genome annotation databases

EnsemblBacteriaiCAB13607; CAB13607; BSU17230.
GeneIDi940046.
KEGGibsu:BSU17230.
PATRICi18975255. VBIBacSub10457_1819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB13607.2.
RefSeqiNP_389605.2. NC_000964.3.
WP_003244857.1. NZ_JNCM01000035.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YZRX-ray1.35A1-405[»]
ProteinModelPortaliO31785.
SMRiO31785.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100009476.

Proteomic databases

PaxDbiO31785.
PRIDEiO31785.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13607; CAB13607; BSU17230.
GeneIDi940046.
KEGGibsu:BSU17230.
PATRICi18975255. VBIBacSub10457_1819.

Phylogenomic databases

eggNOGiENOG4106A3M. Bacteria.
COG2124. LUCA.
HOGENOMiHOG000243678.
InParanoidiO31785.
KOiK15468.
OMAiNKADIMK.
PhylomeDBiO31785.

Enzyme and pathway databases

UniPathwayiUPA01003.
BioCyciBSUB:BSU17230-MONOMER.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKSS_BACSU
AccessioniPrimary (citable) accession number: O31785
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.