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Protein

Sporulation kinase D

Gene

kinD

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions.3 Publications

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Sporulation, Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU13660-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation kinase D (EC:2.7.13.3)
Alternative name(s):
Sensor histidine kinase D
Gene namesi
Name:kinD
Synonyms:ykvD
Ordered Locus Names:BSU13660
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene sporulate normally in spo0F mutants.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Sporulation kinase DPRO_0000375263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei301 – 3011Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO31671.

Expressioni

Inductioni

Expressed during growth and early stationary phase.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100007566.

Structurei

Secondary structure

1
506
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi40 – 7940Combined sources
Helixi86 – 9712Combined sources
Beta strandi103 – 1108Combined sources
Beta strandi114 – 1207Combined sources
Helixi132 – 1409Combined sources
Turni152 – 1543Combined sources
Beta strandi156 – 16611Combined sources
Beta strandi172 – 18110Combined sources
Helixi182 – 19211Combined sources
Beta strandi198 – 2025Combined sources
Beta strandi207 – 2126Combined sources
Helixi214 – 2174Combined sources
Beta strandi223 – 2264Combined sources
Beta strandi228 – 2303Combined sources
Beta strandi232 – 2365Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JGOX-ray2.28A/B37-250[»]
4JGPX-ray2.03A/B37-250[»]
4JGQX-ray2.63A/B37-250[»]
4JGRX-ray2.40A/B37-250[»]
ProteinModelPortaliO31671.
SMRiO31671. Positions 39-245, 289-505.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO31671.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini298 – 505208Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000086165.
InParanoidiO31671.
KOiK13532.
OMAiNNETHAQ.
PhylomeDBiO31671.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR033479. dCache_1.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR029151. Sensor-like.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02743. dCache_1. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF103190. SSF103190. 1 hit.
SSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O31671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLERCKLKIL KGACGRVKLY IILVVIPAIV ISFFVYEKEK DTIAAEHKQE
60 70 80 90 100
ASVLLNLHRN KINYLIGETM ARMTSLSIAI DRPVDIKKMQ SILEKTFDSE
110 120 130 140 150
PRFSGLYFLN AKGDVTASTT ELKTKVNLAD RSFFIKAKET KKTVISDSYS
160 170 180 190 200
SRITGQPIFT ICVPVLDSKR NVTDYLVAAI QIDYLKNLIN LLSPDVYIEV
210 220 230 240 250
VNQDGKMIFA SGQASHAEDQ KPVSGYLDDI SWNMKVYPNP VTIEELSKSL
260 270 280 290 300
VLPLSCIIVL LNILFILVLY YLLKRQTQLE RSENEAQKLE LIGTLAASTA
310 320 330 340 350
HEIRNPLTGI SGFIQLLQKK YKGEEDQLYF SIIEQEIKRI NQIVSEFLVL
360 370 380 390 400
GKPTAEKWEL NSLQDIIGEI MPIIYSEGNL YNVEVELQYL TEQPLLVKCT
410 420 430 440 450
KDHIKQVILN VAKNGLESMP EGGKLTISLG ALDKKAIIKV VDNGEGISQE
460 470 480 490 500
MLDHIFLPFV TSKEKGTGLG LVVCKRIVLM YGGSIHIESE VRRGTEVTIT

LPVSAS
Length:506
Mass (Da):56,704
Last modified:January 1, 1998 - v1
Checksum:i4A93A6A4500C179A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB13239.1.
PIRiF69867.
RefSeqiNP_389249.1. NC_000964.3.
WP_010886497.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB13239; CAB13239; BSU13660.
GeneIDi939300.
KEGGibsu:BSU13660.
PATRICi18974501. VBIBacSub10457_1442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB13239.1.
PIRiF69867.
RefSeqiNP_389249.1. NC_000964.3.
WP_010886497.1. NC_000964.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JGOX-ray2.28A/B37-250[»]
4JGPX-ray2.03A/B37-250[»]
4JGQX-ray2.63A/B37-250[»]
4JGRX-ray2.40A/B37-250[»]
ProteinModelPortaliO31671.
SMRiO31671. Positions 39-245, 289-505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100007566.

Proteomic databases

PaxDbiO31671.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13239; CAB13239; BSU13660.
GeneIDi939300.
KEGGibsu:BSU13660.
PATRICi18974501. VBIBacSub10457_1442.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000086165.
InParanoidiO31671.
KOiK13532.
OMAiNNETHAQ.
PhylomeDBiO31671.

Enzyme and pathway databases

BioCyciBSUB:BSU13660-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO31671.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR033479. dCache_1.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR029151. Sensor-like.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02743. dCache_1. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF103190. SSF103190. 1 hit.
SSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIND_BACSU
AccessioniPrimary (citable) accession number: O31671
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.