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Protein

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase

Gene

mtnX

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).1 Publication

Catalytic activityi

2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate.

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 4 of the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Methylthioribose-1-phosphate isomerase (mtnA)
  2. Methylthioribulose-1-phosphate dehydratase (mtnB)
  3. 2,3-diketo-5-methylthiopentyl-1-phosphate enolase (mtnW)
  4. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase (mtnX)
  5. Acireductone dioxygenase (mtnD)
  6. Transaminase MtnE (mtnE)
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate, the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU13600-MONOMER
MetaCyc:BSU13600-MONOMER
UniPathwayiUPA00904; UER00877

Names & Taxonomyi

Protein namesi
Recommended name:
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase (EC:3.1.3.87)
Short name:
HK-MTPenyl-1-P phosphatase
Gene namesi
Name:mtnX
Synonyms:ykrX
Ordered Locus Names:BSU13600
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966311 – 2352-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphataseAdd BLAST235

Proteomic databases

PaxDbiO31667
PRIDEiO31667

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100007536

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 10Combined sources5
Turni13 – 15Combined sources3
Beta strandi16 – 19Combined sources4
Helixi21 – 29Combined sources9
Helixi33 – 42Combined sources10
Helixi48 – 56Combined sources9
Helixi61 – 63Combined sources3
Helixi64 – 74Combined sources11
Helixi81 – 91Combined sources11
Beta strandi95 – 102Combined sources8
Helixi103 – 110Combined sources8
Turni111 – 113Combined sources3
Helixi116 – 118Combined sources3
Beta strandi119 – 125Combined sources7
Beta strandi127 – 130Combined sources4
Beta strandi132 – 134Combined sources3
Helixi151 – 158Combined sources8
Beta strandi164 – 169Combined sources6
Helixi172 – 174Combined sources3
Helixi175 – 179Combined sources5
Beta strandi182 – 186Combined sources5
Helixi188 – 196Combined sources9
Helixi207 – 215Combined sources9
Helixi218 – 224Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FEAX-ray2.00A/B1-235[»]
ProteinModelPortaliO31667
SMRiO31667
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO31667

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105JAS Bacteria
COG4359 LUCA
HOGENOMiHOG000034443
InParanoidiO31667
KOiK08966
OMAiFVVLSDW

Family and domain databases

Gene3Di3.40.50.1000, 3 hits
HAMAPiMF_01680 Salvage_MtnX, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR017718 HAD-SF_hydro_IB_MtnX
IPR023214 HAD_sf
IPR006384 PyrdxlP_Pase-rel
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01489 DKMTPPase-SF, 1 hit
TIGR03333 salvage_mtnX, 1 hit

Sequencei

Sequence statusi: Complete.

O31667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTRKPFIIC DFDGTITMND NIINIMKTFA PPEWMALKDG VLSKTLSIKE
60 70 80 90 100
GVGRMFGLLP SSLKEEITSF VLEDAKIREG FREFVAFINE HEIPFYVISG
110 120 130 140 150
GMDFFVYPLL EGIVEKDRIY CNHASFDNDY IHIDWPHSCK GTCSNQCGCC
160 170 180 190 200
KPSVIHELSE PNQYIIMIGD SVTDVEAAKL SDLCFARDYL LNECREQNLN
210 220 230
HLPYQDFYEI RKEIENVKEV QEWLQNKNAG ESSLK
Length:235
Mass (Da):27,002
Last modified:January 1, 1998 - v1
Checksum:i69DEF79012653229
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB13233.1
PIRiH69863
RefSeqiNP_389243.1, NC_000964.3
WP_003245748.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13233; CAB13233; BSU13600
GeneIDi939331
KEGGibsu:BSU13600
PATRICifig|224308.179.peg.1477

Similar proteinsi

Entry informationi

Entry nameiMTNX_BACSU
AccessioniPrimary (citable) accession number: O31667
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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