O31646 (MANA1_BACSU) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 81.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Mannose-6-phosphate isomerase ManA EC=5.3.1.8 Alternative name(s): Phosphohexomutase Phosphomannose isomerase Short name=PMI | ||||||
| Gene names |
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| Organism | Bacillus subtilis (strain 168) [Reference proteome] [HAMAP] | ||||||
| Taxonomic identifier | 224308 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › ![]() |
Protein attributes
| Sequence length | 315 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | D-mannose 6-phosphate = D-fructose 6-phosphate. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Disruption phenotype | Cells lacking this gene are unable to grow in minimal medium with mannose as a sole carbon source. They show impaired growth in rich medium, and impairment increases in the presence of greater than 1.4 mM mannose. Ref.3 |
| Sequence similarities | Belongs to the mannose-6-phosphate isomerase type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Zinc |
| Molecular function | Isomerase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular_function | mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [2] | "Novel phosphotransferase system genes revealed by genome analysis - the complete complement of PTS proteins encoded within the genome of Bacillus subtilis." Reizer J., Bachem S., Reizer A., Arnaud M., Saier M.H. Jr., Stuelke J. Microbiology 145:3419-3429(1999) [PubMed] [Europe PMC] [Abstract] Cited for: GENE NAME. Strain: 168. |
| [3] | "Mutations in multidrug efflux homologs, sugar isomerases, and antimicrobial biosynthesis genes differentially elevate activity of the sigma(X) and sigma(W) factors in Bacillus subtilis." Turner M.S., Helmann J.D. J. Bacteriol. 182:5202-5210(2000) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE. Strain: 168. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL009126 Genomic DNA. Translation: CAB13059.1. |
| PIR | H69848. |
| RefSeq | NP_389084.1. NC_000964.3. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1QWR based on UniProtKB P39841. |
| ProteinModelPortal | O31646. |
| SMR | O31646. Positions 2-315. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 224308.BSU12020. |
Proteomic databases | |
| PaxDb | O31646. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | CAB13059; CAB13059; BSU12020. |
| GeneID | 939393. |
| KEGG | bsu:BSU12020. |
| PATRIC | 18974133. VBIBacSub10457_1259. |
Organism-specific databases | |
| GenoList | BSU12020. [Micado] |
Phylogenomic databases | |
| eggNOG | COG1482. |
| HOGENOM | HOG000054245. |
| KO | K01809. |
| OMA | VIETQQS. |
| ProtClustDB | CLSK887088. |
Enzyme and pathway databases | |
| BioCyc | BSUB:BSU12020-MONOMER. |
Family and domain databases | |
| Gene3D | 2.60.120.10. 2 hits. |
| InterPro | IPR001250. Man6P_Isoase-1. IPR014628. Man6P_isomerase_Firm_short. IPR014710. RmlC-like_jellyroll. IPR011051. RmlC_Cupin. [Graphical view] |
| PANTHER | PTHR18964:SF1. PTHR18964:SF1. 1 hit. |
| Pfam | PF01238. PMI_typeI. 1 hit. [Graphical view] |
| PIRSF | PIRSF036894. PMI_Firm_short. 1 hit. |
| SUPFAM | SSF51182. RmlC_like_cupin. 1 hit. |
| TIGRFAMs | TIGR00218. manA. 2 hits. |
| PROSITE | PS00965. PMI_I_1. False negative. PS00966. PMI_I_2. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MANA1_BACSU | ||||||||
| Accession | Primary (citable) accession number: O31646 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| SIMILARITY comments Index of protein domains and families |

Clusters with
