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O31644 (MANR_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable transcriptional regulator ManR

Including the following 2 domains:

  1. Putative phosphotransferase enzyme IIB component
    EC=2.7.1.69
    Alternative name(s):
    Putative PTS system EIIB component
  2. Putative phosphotransferase enzyme IIA component
    EC=2.7.1.-
    Alternative name(s):
    Putative PTS system EIIA component
Gene names
Name:manR
Ordered Locus Names:BSU12000
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May regulate the expression of the mannose operon.

Catalytic activity

Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.

Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.

Domain

The PTS EIIB type-2 domain may serve a regulatory function, through its phosphorylation activity.

The PTS EIIA type-2 domain may serve a regulatory function, through its phosphorylation activity.

Miscellaneous

Might be activated by phosphorylation of certain histidyl residues by HPr By similarity.

Sequence similarities

Belongs to the transcriptional antiterminator BglG family.

Contains 2 PRD domains.

Contains 1 PTS EIIA type-2 domain.

Contains 1 PTS EIIB type-2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 648648Probable transcriptional regulator ManR
PRO_0000376080

Regions

Domain187 – 292106PRD 1
Domain297 – 404108PRD 2
Domain409 – 50092PTS EIIB type-2
Domain510 – 648139PTS EIIA type-2

Amino acid modifications

Modified residue2221Phosphohistidine Potential
Modified residue2811Phosphohistidine Potential
Modified residue3341Phosphohistidine Potential
Modified residue3931Phosphohistidine Potential
Modified residue4151Phosphocysteine; by EIIA By similarity
Modified residue5701Phosphohistidine; by HPr By similarity

Sequences

Sequence LengthMass (Da)Tools
O31644 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: E987358049EBA550

FASTA64875,351
        10         20         30         40         50         60 
MEYINTRQKE ILYLLLSEPD DYLVVQDFAD RVQCSEKTIR NDLKVIEDYL NEHSHAQLIR 

        70         80         90        100        110        120 
KPGLGVYLHI EEQERTWLSQ QLHTEHFSSR QRSDKERMLH IAYDLLMNPK PVSAKDIAAR 

       130        140        150        160        170        180 
HFVNRSSIKK DLYAVEEWLK RFDLTLVSRQ RLGLKVEGNE RNKRKALARI SDLIHNTAFT 

       190        200        210        220        230        240 
SQFIKSKFLH YEVDFVTKEI KSLQKKHSLY FTDETFESLL LHTLLMVRRI KMKQPISLSP 

       250        260        270        280        290        300 
KEMAAVKKKK EYQWTFACLQ RLEPVFAIRF PEEEAVYLTL HILGGKVRYP LQTEENLENA 

       310        320        330        340        350        360 
VLPKVVGHLI NRVSELKMMD FHKDQDLING LNIHLNTVLQ RLSYDLSVAN PMLNDIKKMY 

       370        380        390        400        410        420 
PYLFHLIIDV LEDINQTFDL HIPEEEAAYL TLHFQAAIER MQGSSETHKK AVIVCHMGIG 

       430        440        450        460        470        480 
MSQLLRTKIE RKYHQIAVMA CIAKADLKDY IKKHEDIDLV ISTIALENIT VPHIVVSPLL 

       490        500        510        520        530        540 
EPGEEKKLSA FIRQLGESHR QKQKTFQMLN NTTPFLVFLQ QEAEHRYKLI EQLATALFEK 

       550        560        570        580        590        600 
GYVDKDYAVH AVMREKMSAT NIGSGIAIPH ANAKFIKQSA IAIATLKEPL EWGNEKVSLV 

       610        620        630        640 
FMLAVKHEDQ TMTKQLFSEL SYLSEQPAFV QKLTKETNVM TFLSHLDY

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[2]"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
Microbiology 155:1758-1775(2009) [PubMed: 19383706] [Abstract]
Cited for: SEQUENCE REVISION TO 106.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL009126 Genomic DNA. Translation: CAB13057.2.
RefSeqNP_389082.2. NC_000964.3.

3D structure databases

ProteinModelPortalO31644.
SMRO31644. Positions 194-285, 302-398, 409-492, 511-648.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000000740; EBBACP00000000740; EBBACG00000000738.
GeneID939394.
GenomeReviewsGene locus BSU12000 in contig AL009126_GR.
KEGGbsu:BSU12000.
NMPDRfig|224308.1.peg.1201.
PATRIC18974129. VBIBacSub10457_1257.

Organism-specific databases

GenoListBSU12000. [Micado]

Phylogenomic databases

GeneTreeEBGT00070000032076.
HOGENOMHBG338196.
PhylomeDBO31644.
ProtClustDBCLSK887087.

Enzyme and pathway databases

BioCycBSUB:BSU12000-MONOMER.

Family and domain databases

InterProIPR013196. HTH_11.
IPR007737. Mga.
IPR011608. PRD.
IPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_2.
IPR013011. PTS_EIIB_2.
IPR011991. WHTH_trsnscrt_rep_DNA-bd.
[Graphical view]
Gene3DG3DSA:1.10.1790.10. PRD. 2 hits.
G3DSA:3.40.930.10. PTS_EIIA_2. 1 hit.
G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 2 hits.
KOK02538.
PfamPF08279. HTH_11. 1 hit.
PF05043. Mga. 1 hit.
PF00874. PRD. 2 hits.
PF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
SUPFAMSSF63520. PRD. 2 hits.
SSF55804. PTrfase/Anion_transptr. 1 hit.
PROSITEPS00654. PRD_1. False negative.
PS51372. PRD_2. 2 hits.
PS51094. PTS_EIIA_TYPE_2. 1 hit.
PS00372. PTS_EIIA_TYPE_2_HIS. 1 hit.
PS51099. PTS_EIIB_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMANR_BACSU
AccessionPrimary (citable) accession number: O31644
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 5, 2009
Last modified: January 25, 2012
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents