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O31611

- YJBM_BACSU

UniProt

O31611 - YJBM_BACSU

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Protein

GTP pyrophosphokinase YjbM

Gene
yjbM, BSU11600
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. YjbM has probably a minor role in stringent response.1 Publication

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. GTP diphosphokinase activity Source: UniProtKB-EC
  4. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU11600-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP pyrophosphokinase YjbM (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase YjbM
Small alarmone synthase 1
Short name:
SAS 1
Gene namesi
Name:yjbM
Ordered Locus Names:BSU11600
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU11600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211GTP pyrophosphokinase YjbMPRO_0000390876Add
BLAST

Proteomic databases

PaxDbiO31611.

Expressioni

Inductioni

Expressed during exponential growth through the transition to the stationary phase, but not during entry of cells into stationary phase.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU11600.

Structurei

3D structure databases

ProteinModelPortaliO31611.
SMRiO31611. Positions 4-203.

Family & Domainsi

Sequence similaritiesi

Belongs to the RelA/SpoT family.

Phylogenomic databases

eggNOGiCOG2357.
HOGENOMiHOG000263233.
KOiK07816.
OMAiVVEYPVQ.
OrthoDBiEOG6P5ZJ6.
PhylomeDBiO31611.

Family and domain databases

InterProiIPR007685. RelA_SpoT.
[Graphical view]
PfamiPF04607. RelA_SpoT. 1 hit.
[Graphical view]
SMARTiSM00954. RelA_SpoT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O31611-1 [UniParc]FASTAAdd to Basket

« Hide

MDDKQWERFL VPYRQAVEEL KVKLKGIRTL YEYEDDHSPI EFVTGRVKPV    50
ASILEKARRK SIPLHEIETM QDIAGLRIMC QFVDDIQIVK EMLFARKDFT 100
VVDQRDYIAE HKESGYRSYH LVVLYPLQTV SGEKHVLVEI QIRTLAMNFW 150
ATIEHSLNYK YSGNIPEKVK LRLQRASEAA SRLDEEMSEI RGEVQEAQAA 200
FSRKKKGSEQ Q 211
Length:211
Mass (Da):24,704
Last modified:January 1, 1998 - v1
Checksum:i8FB2A73CE865FAA2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB13017.1.
PIRiE69844.
RefSeqiNP_389042.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB13017; CAB13017; BSU11600.
GeneIDi939809.
KEGGibsu:BSU11600.
PATRICi18974037. VBIBacSub10457_1212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL009126 Genomic DNA. Translation: CAB13017.1 .
PIRi E69844.
RefSeqi NP_389042.1. NC_000964.3.

3D structure databases

ProteinModelPortali O31611.
SMRi O31611. Positions 4-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU11600.

Proteomic databases

PaxDbi O31611.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB13017 ; CAB13017 ; BSU11600 .
GeneIDi 939809.
KEGGi bsu:BSU11600.
PATRICi 18974037. VBIBacSub10457_1212.

Organism-specific databases

GenoListi BSU11600.

Phylogenomic databases

eggNOGi COG2357.
HOGENOMi HOG000263233.
KOi K07816.
OMAi VVEYPVQ.
OrthoDBi EOG6P5ZJ6.
PhylomeDBi O31611.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci BSUB:BSU11600-MONOMER.

Family and domain databases

InterProi IPR007685. RelA_SpoT.
[Graphical view ]
Pfami PF04607. RelA_SpoT. 1 hit.
[Graphical view ]
SMARTi SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  2. "Identification and functional analysis of novel (p)ppGpp synthetase genes in Bacillus subtilis."
    Nanamiya H., Kasai K., Nozawa A., Yun C.S., Narisawa T., Murakami K., Natori Y., Kawamura F., Tozawa Y.
    Mol. Microbiol. 67:291-304(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A (P)PPGPP SYNTHASE, INDUCTION.
    Strain: 168.

Entry informationi

Entry nameiYJBM_BACSU
AccessioniPrimary (citable) accession number: O31611
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

GDP can be used instead of GTP, resulting in an increase of (p)ppGpp synthesis. The synthase activity of YjbM is greater than that of YwaC.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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