Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O31611

- YJBM_BACSU

UniProt

O31611 - YJBM_BACSU

Protein

GTP pyrophosphokinase YjbM

Gene

yjbM

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. YjbM has probably a minor role in stringent response.1 Publication

    Catalytic activityi

    ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. GTP binding Source: UniProtKB-KW
    3. GTP diphosphokinase activity Source: UniProtKB-EC
    4. kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBSUB:BSU11600-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP pyrophosphokinase YjbM (EC:2.7.6.5)
    Alternative name(s):
    (p)ppGpp synthase YjbM
    Small alarmone synthase 1
    Short name:
    SAS 1
    Gene namesi
    Name:yjbM
    Ordered Locus Names:BSU11600
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU11600.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211GTP pyrophosphokinase YjbMPRO_0000390876Add
    BLAST

    Proteomic databases

    PaxDbiO31611.

    Expressioni

    Inductioni

    Expressed during exponential growth through the transition to the stationary phase, but not during entry of cells into stationary phase.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU11600.

    Structurei

    3D structure databases

    ProteinModelPortaliO31611.
    SMRiO31611. Positions 4-203.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RelA/SpoT family.Curated

    Phylogenomic databases

    eggNOGiCOG2357.
    HOGENOMiHOG000263233.
    KOiK07816.
    OMAiVVEYPVQ.
    OrthoDBiEOG6P5ZJ6.
    PhylomeDBiO31611.

    Family and domain databases

    InterProiIPR007685. RelA_SpoT.
    [Graphical view]
    PfamiPF04607. RelA_SpoT. 1 hit.
    [Graphical view]
    SMARTiSM00954. RelA_SpoT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O31611-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDKQWERFL VPYRQAVEEL KVKLKGIRTL YEYEDDHSPI EFVTGRVKPV    50
    ASILEKARRK SIPLHEIETM QDIAGLRIMC QFVDDIQIVK EMLFARKDFT 100
    VVDQRDYIAE HKESGYRSYH LVVLYPLQTV SGEKHVLVEI QIRTLAMNFW 150
    ATIEHSLNYK YSGNIPEKVK LRLQRASEAA SRLDEEMSEI RGEVQEAQAA 200
    FSRKKKGSEQ Q 211
    Length:211
    Mass (Da):24,704
    Last modified:January 1, 1998 - v1
    Checksum:i8FB2A73CE865FAA2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB13017.1.
    PIRiE69844.
    RefSeqiNP_389042.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB13017; CAB13017; BSU11600.
    GeneIDi939809.
    KEGGibsu:BSU11600.
    PATRICi18974037. VBIBacSub10457_1212.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB13017.1 .
    PIRi E69844.
    RefSeqi NP_389042.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali O31611.
    SMRi O31611. Positions 4-203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU11600.

    Proteomic databases

    PaxDbi O31611.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB13017 ; CAB13017 ; BSU11600 .
    GeneIDi 939809.
    KEGGi bsu:BSU11600.
    PATRICi 18974037. VBIBacSub10457_1212.

    Organism-specific databases

    GenoListi BSU11600.

    Phylogenomic databases

    eggNOGi COG2357.
    HOGENOMi HOG000263233.
    KOi K07816.
    OMAi VVEYPVQ.
    OrthoDBi EOG6P5ZJ6.
    PhylomeDBi O31611.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci BSUB:BSU11600-MONOMER.

    Family and domain databases

    InterProi IPR007685. RelA_SpoT.
    [Graphical view ]
    Pfami PF04607. RelA_SpoT. 1 hit.
    [Graphical view ]
    SMARTi SM00954. RelA_SpoT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    2. "Identification and functional analysis of novel (p)ppGpp synthetase genes in Bacillus subtilis."
      Nanamiya H., Kasai K., Nozawa A., Yun C.S., Narisawa T., Murakami K., Natori Y., Kawamura F., Tozawa Y.
      Mol. Microbiol. 67:291-304(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A (P)PPGPP SYNTHASE, INDUCTION.
      Strain: 168.

    Entry informationi

    Entry nameiYJBM_BACSU
    AccessioniPrimary (citable) accession number: O31611
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 19, 2010
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    GDP can be used instead of GTP, resulting in an increase of (p)ppGpp synthesis. The synthase activity of YjbM is greater than that of YwaC.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3