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Protein

GTP pyrophosphokinase YjbM

Gene

yjbM

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. YjbM has probably a minor role in stringent response.1 Publication

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. GTP diphosphokinase activity Source: UniProtKB-EC
  4. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU11600-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP pyrophosphokinase YjbM (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase YjbM
Small alarmone synthase 1
Short name:
SAS 1
Gene namesi
Name:yjbM
Ordered Locus Names:BSU11600
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU11600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211GTP pyrophosphokinase YjbMPRO_0000390876Add
BLAST

Proteomic databases

PaxDbiO31611.

Expressioni

Inductioni

Expressed during exponential growth through the transition to the stationary phase, but not during entry of cells into stationary phase.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU11600.

Structurei

3D structure databases

ProteinModelPortaliO31611.
SMRiO31611. Positions 4-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RelA/SpoT family.Curated

Phylogenomic databases

eggNOGiCOG2357.
HOGENOMiHOG000263233.
InParanoidiO31611.
KOiK07816.
OMAiHEEMYDI.
OrthoDBiEOG6P5ZJ6.
PhylomeDBiO31611.

Family and domain databases

InterProiIPR007685. RelA_SpoT.
[Graphical view]
PfamiPF04607. RelA_SpoT. 1 hit.
[Graphical view]
SMARTiSM00954. RelA_SpoT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O31611-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDKQWERFL VPYRQAVEEL KVKLKGIRTL YEYEDDHSPI EFVTGRVKPV
60 70 80 90 100
ASILEKARRK SIPLHEIETM QDIAGLRIMC QFVDDIQIVK EMLFARKDFT
110 120 130 140 150
VVDQRDYIAE HKESGYRSYH LVVLYPLQTV SGEKHVLVEI QIRTLAMNFW
160 170 180 190 200
ATIEHSLNYK YSGNIPEKVK LRLQRASEAA SRLDEEMSEI RGEVQEAQAA
210
FSRKKKGSEQ Q
Length:211
Mass (Da):24,704
Last modified:January 1, 1998 - v1
Checksum:i8FB2A73CE865FAA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB13017.1.
PIRiE69844.
RefSeqiNP_389042.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB13017; CAB13017; BSU11600.
GeneIDi939809.
KEGGibsu:BSU11600.
PATRICi18974037. VBIBacSub10457_1212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB13017.1.
PIRiE69844.
RefSeqiNP_389042.1. NC_000964.3.

3D structure databases

ProteinModelPortaliO31611.
SMRiO31611. Positions 4-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.BSU11600.

Proteomic databases

PaxDbiO31611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13017; CAB13017; BSU11600.
GeneIDi939809.
KEGGibsu:BSU11600.
PATRICi18974037. VBIBacSub10457_1212.

Organism-specific databases

GenoListiBSU11600.

Phylogenomic databases

eggNOGiCOG2357.
HOGENOMiHOG000263233.
InParanoidiO31611.
KOiK07816.
OMAiHEEMYDI.
OrthoDBiEOG6P5ZJ6.
PhylomeDBiO31611.

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.
BioCyciBSUB:BSU11600-MONOMER.

Family and domain databases

InterProiIPR007685. RelA_SpoT.
[Graphical view]
PfamiPF04607. RelA_SpoT. 1 hit.
[Graphical view]
SMARTiSM00954. RelA_SpoT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  2. "Identification and functional analysis of novel (p)ppGpp synthetase genes in Bacillus subtilis."
    Nanamiya H., Kasai K., Nozawa A., Yun C.S., Narisawa T., Murakami K., Natori Y., Kawamura F., Tozawa Y.
    Mol. Microbiol. 67:291-304(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A (P)PPGPP SYNTHASE, INDUCTION.
    Strain: 168.

Entry informationi

Entry nameiYJBM_BACSU
AccessioniPrimary (citable) accession number: O31611
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: January 1, 1998
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

GDP can be used instead of GTP, resulting in an increase of (p)ppGpp synthesis. The synthase activity of YjbM is greater than that of YwaC.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.