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O31611 (YJBM_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP pyrophosphokinase YjbM

EC=2.7.6.5
Alternative name(s):
(p)ppGpp synthase YjbM
Small alarmone synthase 1
Short name=SAS 1
Gene names
Name:yjbM
Ordered Locus Names:BSU11600
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. YjbM has probably a minor role in stringent response. Ref.2

Catalytic activity

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.

Induction

Expressed during exponential growth through the transition to the stationary phase, but not during entry of cells into stationary phase. Ref.2

Miscellaneous

GDP can be used instead of GTP, resulting in an increase of (p)ppGpp synthesis. The synthase activity of YjbM is greater than that of YwaC.

Sequence similarities

Belongs to the RelA/SpoT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211GTP pyrophosphokinase YjbM
PRO_0000390876

Sequences

Sequence LengthMass (Da)Tools
O31611 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 8FB2A73CE865FAA2

FASTA21124,704
        10         20         30         40         50         60 
MDDKQWERFL VPYRQAVEEL KVKLKGIRTL YEYEDDHSPI EFVTGRVKPV ASILEKARRK 

        70         80         90        100        110        120 
SIPLHEIETM QDIAGLRIMC QFVDDIQIVK EMLFARKDFT VVDQRDYIAE HKESGYRSYH 

       130        140        150        160        170        180 
LVVLYPLQTV SGEKHVLVEI QIRTLAMNFW ATIEHSLNYK YSGNIPEKVK LRLQRASEAA 

       190        200        210 
SRLDEEMSEI RGEVQEAQAA FSRKKKGSEQ Q 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[2]"Identification and functional analysis of novel (p)ppGpp synthetase genes in Bacillus subtilis."
Nanamiya H., Kasai K., Nozawa A., Yun C.S., Narisawa T., Murakami K., Natori Y., Kawamura F., Tozawa Y.
Mol. Microbiol. 67:291-304(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS A (P)PPGPP SYNTHASE, INDUCTION.
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL009126 Genomic DNA. Translation: CAB13017.1.
PIRE69844.
RefSeqNP_389042.1. NC_000964.3.

3D structure databases

ProteinModelPortalO31611.
SMRO31611. Positions 4-203.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU11600.

Proteomic databases

PaxDbO31611.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB13017; CAB13017; BSU11600.
GeneID939809.
KEGGbsu:BSU11600.
PATRIC18974037. VBIBacSub10457_1212.

Organism-specific databases

GenoListBSU11600.

Phylogenomic databases

eggNOGCOG2357.
HOGENOMHOG000263233.
KOK07816.
OMAHMIVEYP.
OrthoDBEOG6P5ZJ6.
ProtClustDBCLSK887070.

Enzyme and pathway databases

BioCycBSUB:BSU11600-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

InterProIPR007685. RelA_SpoT.
[Graphical view]
PfamPF04607. RelA_SpoT. 1 hit.
[Graphical view]
SMARTSM00954. RelA_SpoT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYJBM_BACSU
AccessionPrimary (citable) accession number: O31611
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: January 1, 1998
Last modified: November 13, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList