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Protein

Regulatory protein Spx

Gene

spxA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Negatively affects competence and sporulation. Its degradation by the MecA/ClpXP complex is needed for competence development.UniRule annotation2 Publications

GO - Biological processi

Keywordsi

Biological processStress response, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciBSUB:BSU11500-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein SpxUniRule annotation
Gene namesi
Name:spxAUniRule annotation
Synonyms:yjbD
Ordered Locus Names:BSU11500
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi130 – 131AN → DD: Resistant to degradation by ClpXP. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625511 – 131Regulatory protein SpxAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi10 ↔ 13Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO31602
PRIDEiO31602

Expressioni

Inductioni

By heat, salt, ethanol and disulfide stress and also by phosphate limitation. Transcribed under partial control of SigM ECF sigma factor (PubMed:17434969).1 Publication

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiO31602, 3 interactors
STRINGi224308.Bsubs1_010100006356

Structurei

Secondary structure

1131
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi11 – 22Combined sources12
Beta strandi27 – 31Combined sources5
Turni32 – 34Combined sources3
Helixi39 – 47Combined sources9
Helixi53 – 55Combined sources3
Helixi62 – 67Combined sources6
Helixi71 – 73Combined sources3
Helixi76 – 85Combined sources10
Helixi87 – 89Combined sources3
Beta strandi94 – 96Combined sources3
Beta strandi101 – 104Combined sources4
Helixi109 – 113Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z3EX-ray1.50A1-131[»]
3GFKX-ray2.30A1-131[»]
3IHQX-ray1.90A1-131[»]
ProteinModelPortaliO31602
SMRiO31602
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO31602

Family & Domainsi

Sequence similaritiesi

Belongs to the ArsC family. Spx subfamily.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG41090SU Bacteria
COG1393 LUCA
HOGENOMiHOG000059715
InParanoidiO31602
KOiK16509
OMAiKILRMTE
PhylomeDBiO31602

Family and domain databases

HAMAPiMF_01132 SpxA, 1 hit
InterProiView protein in InterPro
IPR006660 Arsenate_reductase-like
IPR023731 Spx
IPR036249 Thioredoxin-like_sf
IPR006504 Tscrpt_reg_Spx/MgsR
PfamiView protein in Pfam
PF03960 ArsC, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01617 arsC_related, 1 hit
PROSITEiView protein in PROSITE
PS51353 ARSC, 1 hit

Sequencei

Sequence statusi: Complete.

O31602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTLYTSPSC TSCRKARAWL EEHEIPFVER NIFSEPLSID EIKQILRMTE
60 70 80 90 100
DGTDEIISTR SKVFQKLNVN VESMPLQDLY RLINEHPGLL RRPIIIDEKR
110 120 130
LQVGYNEDEI RRFLPRKVRS FQLREAQRLA N
Length:131
Mass (Da):15,529
Last modified:January 1, 1998 - v1
Checksum:iE296B3B7A90397D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB13007.1
PIRiD69843
RefSeqiNP_389032.1, NC_000964.3
WP_003245483.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13007; CAB13007; BSU11500
GeneIDi936407
KEGGibsu:BSU11500
PATRICifig|224308.179.peg.1237

Similar proteinsi

Entry informationi

Entry nameiSPX_BACSU
AccessioniPrimary (citable) accession number: O31602
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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