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Protein

Acetoin dehydrogenase operon transcriptional activator AcoR

Gene

acoR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator of the acoABCL operon encoding the acetoin dehydrogenase complex.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi323 – 3308ATPPROSITE-ProRule annotation
Nucleotide bindingi387 – 39610ATPPROSITE-ProRule annotation
DNA bindingi578 – 59720H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU08100-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetoin dehydrogenase operon transcriptional activator AcoR
Gene namesi
Name:acoR
Synonyms:yfjG, yzcB
Ordered Locus Names:BSU08100
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605Acetoin dehydrogenase operon transcriptional activator AcoRPRO_0000361683Add
BLAST

Proteomic databases

PaxDbiO31551.

Expressioni

Inductioni

Negatively controlled by CcpA, a global regulator of carbon catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100004508.

Structurei

3D structure databases

ProteinModelPortaliO31551.
SMRiO31551. Positions 290-598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini295 – 520226Sigma-54 factor interactionPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 sigma-54 factor interaction domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108JU9. Bacteria.
COG3284. LUCA.
HOGENOMiHOG000058487.
InParanoidiO31551.
OMAiARPVMEN.
PhylomeDBiO31551.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR002078. Sigma_54_int.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02954. HTH_8. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PRINTSiPR01590. HTHFIS.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O31551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSVPNDLQT WKRFVKDGVL DEARLRKRIA ESWHRCKKAE VNPYLEKGPK
60 70 80 90 100
VLQQTELDQQ SKKHSFFLTT AKPYLEKLLP AIKEMEMMAL LIDSDGVVLA
110 120 130 140 150
LDGHPRALYE AKRINFVEGA CWTETAVGTN AIGTALHISE PVAIQGSEHY
160 170 180 190 200
SIASHLWNCS AAPIHHEDGS LAGVIDISCP AAGAHPHMLG IATAIAYAAE
210 220 230 240 250
RELAAKSREK ELELISRFGE RAASSVPMVL CNTKQHIISA SMPIRTSMPD
260 270 280 290 300
WQGRHLYELK ERGYSIENAV TIGDGGTCFY LSEQKKKKAF RFNGVIGQSG
310 320 330 340 350
RSQAMLMHLE RAAATDASVC LSGETGTGKE VAARALHENS ERRHGPFVAV
360 370 380 390 400
NCGAIPSDLI ESELFGYAEG AFTGAKRNGY KGAFQKANQG TLFLDEIGEI
410 420 430 440 450
SHSMQVALLR VLQERKITPI GGTKEIPVDI RVIAATHCDL RELAENGKIR
460 470 480 490 500
EDLFYRLHVY PIELPPLRDR TEDIPDLFEY YKQKNHWPGD LPSDFCNVLK
510 520 530 540 550
QWKWPGNIRE LFNVFERLSI RFPDGRLRDE SLPALLEAAG LPASSAEKKP
560 570 580 590 600
AAAGVLTFRE QIQKDMMIKA LESAKGNVSQ AAKISGIPRS TFYKRLKKFN

LSAES
Length:605
Mass (Da):67,160
Last modified:January 1, 1998 - v1
Checksum:i59B594470E9CD8CC
GO

Sequence cautioni

The sequence AAC05586 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti550 – 5501P → A in AAC05586 (PubMed:10368162).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78509 Genomic DNA. Translation: BAA24292.1.
AL009126 Genomic DNA. Translation: CAB12639.1.
AF006075 Genomic DNA. Translation: AAC05586.1. Different initiation.
PIRiH69581.
RefSeqiNP_388691.1. NC_000964.3.
WP_003244100.1. NZ_JNCM01000032.1.

Genome annotation databases

EnsemblBacteriaiCAB12639; CAB12639; BSU08100.
GeneIDi936148.
KEGGibsu:BSU08100.
PATRICi18973270. VBIBacSub10457_0849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78509 Genomic DNA. Translation: BAA24292.1.
AL009126 Genomic DNA. Translation: CAB12639.1.
AF006075 Genomic DNA. Translation: AAC05586.1. Different initiation.
PIRiH69581.
RefSeqiNP_388691.1. NC_000964.3.
WP_003244100.1. NZ_JNCM01000032.1.

3D structure databases

ProteinModelPortaliO31551.
SMRiO31551. Positions 290-598.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100004508.

Proteomic databases

PaxDbiO31551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12639; CAB12639; BSU08100.
GeneIDi936148.
KEGGibsu:BSU08100.
PATRICi18973270. VBIBacSub10457_0849.

Phylogenomic databases

eggNOGiENOG4108JU9. Bacteria.
COG3284. LUCA.
HOGENOMiHOG000058487.
InParanoidiO31551.
OMAiARPVMEN.
PhylomeDBiO31551.

Enzyme and pathway databases

BioCyciBSUB:BSU08100-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR002078. Sigma_54_int.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02954. HTH_8. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PRINTSiPR01590. HTHFIS.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACOR_BACSU
AccessioniPrimary (citable) accession number: O31551
Secondary accession number(s): O31406, Q79F13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.