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Protein

Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system

Gene

acoC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.

Cofactori

(R)-lipoateBy similarityNote: Binds 1 lipoyl cofactor covalently.By similarity

Pathwayi: acetoin degradation

This protein is involved in the pathway acetoin degradation, which is part of Ketone degradation.
View all proteins of this organism that are known to be involved in the pathway acetoin degradation and in Ketone degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei371Sequence analysis1
Active sitei375Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAcetoin catabolism

Enzyme and pathway databases

BioCyciBSUB:BSU08080-MONOMER
UniPathwayiUPA00040

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system (EC:2.3.1.12)
Alternative name(s):
Acetoin dehydrogenase E2 component
Dihydrolipoamide acetyltransferase component of acetoin cleaving system
Gene namesi
Name:acoC
Synonyms:yfjI
Ordered Locus Names:BSU08080
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001623061 – 398Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving systemAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43N6-lipoyllysinePROSITE-ProRule annotationBy similarity1

Proteomic databases

PaxDbiO31550
PRIDEiO31550

Interactioni

Protein-protein interaction databases

IntActiO31550, 6 interactors
STRINGi224308.Bsubs1_010100004498

Structurei

3D structure databases

ProteinModelPortaliO31550
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 77Lipoyl-bindingPROSITE-ProRule annotationAdd BLAST76
Domaini118 – 155Peripheral subunit-binding (PSBD)PROSITE-ProRule annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.Curated

Keywords - Domaini

Lipoyl

Phylogenomic databases

eggNOGiENOG4107QKR Bacteria
COG0508 LUCA
HOGENOMiHOG000281566
InParanoidiO31550
KOiK00627
OMAiDNLCEVQ
PhylomeDBiO31550

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

O31550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVKVVMPKL GMAMKQGEVS IWNKKVGDPV EKGESIASIQ SEKIEMEIEA
60 70 80 90 100
PEKGTLIDIK VKEGEEVPPG TAICYIGDAN ESVQEEAGAP VAEDNMPQAV
110 120 130 140 150
QPVKQENKPA ASKKDRMKIS PVARKIAEKA GLDLKQLKGT GPGGRIVKDD
160 170 180 190 200
VTKALAEQKK DQAKPVSEQK AQEIPVTGMR KVIAARMQES LANSAQLTIT
210 220 230 240 250
MKADITKLAT LQKQLSPTAE ERYGTKLTIT HFVSRAAVLA LQAHPVLNSF
260 270 280 290 300
YQNERIITHP HVHLGMAVAL ENGLVVPVIR HAEKLSLIEL AQSISENAKK
310 320 330 340 350
AREGRAGSEE LQGSTFSITN LGAFGVEHFT PILNPPETGI LGIGASYDTP
360 370 380 390
VYQGEEIVRS TILPLSLTFD HRACDGAPAA AFLKAMKTYL EEPAALIL
Length:398
Mass (Da):42,886
Last modified:January 1, 1998 - v1
Checksum:i559564C27C1C64F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78509 Genomic DNA Translation: BAA24294.1
AL009126 Genomic DNA Translation: CAB12637.1
PIRiF69581
RefSeqiNP_388689.1, NC_000964.3
WP_003244059.1, NZ_JNCM01000032.1

Genome annotation databases

EnsemblBacteriaiCAB12637; CAB12637; BSU08080
GeneIDi936147
KEGGibsu:BSU08080
PATRICifig|224308.179.peg.874

Similar proteinsi

Entry informationi

Entry nameiACOC_BACSU
AccessioniPrimary (citable) accession number: O31550
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health