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Protein

Sensor histidine kinase YesM

Gene

yesM

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system YesM/YesN. Probably activates YesN by phosphorylation.1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU06950-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor histidine kinase YesM (EC:2.7.13.3)
Gene namesi
Name:yesM
Ordered Locus Names:BSU06950
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence analysisAdd
BLAST
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Topological domaini39 – 286248ExtracellularSequence analysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence analysisAdd
BLAST
Topological domaini308 – 577270CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Sensor histidine kinase YesMPRO_0000360782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei392 – 3921Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO31516.
PRIDEiO31516.

Interactioni

Protein-protein interaction databases

IntActiO31516. 1 interaction.
STRINGi224308.Bsubs1_010100003913.

Structurei

3D structure databases

ProteinModelPortaliO31516.
SMRiO31516. Positions 312-368, 475-573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini312 – 36857HAMPPROSITE-ProRule annotationAdd
BLAST
Domaini365 – 574210Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C2F. Bacteria.
COG2972. LUCA.
HOGENOMiHOG000050083.
InParanoidiO31516.
KOiK07718.
OMAiIHYALEP.
OrthoDBiEOG6RVFWR.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR004358. Sig_transdc_His_kin-like_C.
IPR010559. Sig_transdc_His_kin_internal.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF06580. His_kinase. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O31516-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKRVAGWYR RMKIKDKLFV FLSLIMAVSF LFVYSGVQYA FHVYDEQIYR
60 70 80 90 100
KSSEVLRMSS ERIEDELKKI EDVSYEIITD EQIQRILSMQ NRDDTYDQYQ
110 120 130 140 150
MKQELWDQLA GYASDEKYID SIHVIDARGS EYSAGSSSSD LLQQEQEEVF
160 170 180 190 200
KRAKAKSGRN LWMTLGGSDP VLISARQIRS YHQLSLNGLG MVLIQVNVKQ
210 220 230 240 250
MIRDVPKDWG DSVGDIMIAD QGGNLVYTAH ASAHVPEAAK ETLKHPGYDL
260 270 280 290 300
IKKNGKRYFI SYLQSSYQNW SYYNVIPFDQ MFAKISFMKT VIGTCFLLFF
310 320 330 340 350
CVVLLFGRKI ANSITEPIEQ LVTAMKSVQH SGIEAGVSLS LPEHTQDEAG
360 370 380 390 400
MLNRHFTVMM KRINELMEEN VEKQLIIKET ELKALQAQIN PHFLYNTLES
410 420 430 440 450
INWLAKANQQ KQISKMVESL GFLLRNSIHM KKDIVTIQEE ADIVRHYMTI
460 470 480 490 500
QRFRFEERLK FTLDIDDEVK HCLIPKLTLQ PLAENAIQYA LEPFTRPCAI
510 520 530 540 550
RIQAKKAKGC VCITVEDNGP GMDGRILEST GGRGIGLWNI RERISLTFGE
560 570
PYGLRIHSEH EKGTRIVITI PCRNEVV
Length:577
Mass (Da):66,347
Last modified:January 1, 1998 - v1
Checksum:iCC52FDF5CC3F9FE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB12514.1.
PIRiD69796.
RefSeqiNP_388576.1. NC_000964.3.
WP_003243833.1. NZ_JNCM01000032.1.

Genome annotation databases

EnsemblBacteriaiCAB12514; CAB12514; BSU06950.
GeneIDi936078.
KEGGibsu:BSU06950.
PATRICi18973038. VBIBacSub10457_0733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB12514.1.
PIRiD69796.
RefSeqiNP_388576.1. NC_000964.3.
WP_003243833.1. NZ_JNCM01000032.1.

3D structure databases

ProteinModelPortaliO31516.
SMRiO31516. Positions 312-368, 475-573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO31516. 1 interaction.
STRINGi224308.Bsubs1_010100003913.

Proteomic databases

PaxDbiO31516.
PRIDEiO31516.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12514; CAB12514; BSU06950.
GeneIDi936078.
KEGGibsu:BSU06950.
PATRICi18973038. VBIBacSub10457_0733.

Phylogenomic databases

eggNOGiENOG4105C2F. Bacteria.
COG2972. LUCA.
HOGENOMiHOG000050083.
InParanoidiO31516.
KOiK07718.
OMAiIHYALEP.
OrthoDBiEOG6RVFWR.

Enzyme and pathway databases

BioCyciBSUB:BSU06950-MONOMER.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR004358. Sig_transdc_His_kin-like_C.
IPR010559. Sig_transdc_His_kin_internal.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF06580. His_kinase. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  2. "Comprehensive DNA microarray analysis of Bacillus subtilis two-component regulatory systems."
    Kobayashi K., Ogura M., Yamaguchi H., Yoshida K., Ogasawara N., Tanaka T., Fujita Y.
    J. Bacteriol. 183:7365-7370(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiYESM_BACSU
AccessioniPrimary (citable) accession number: O31516
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: February 17, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.