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Protein

Sec-independent protein translocase protein TatAd

Gene

tatAd

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. Required for PhoD secretion. The cytosolic fraction of TatAd binds the precursor of PhoD.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU02630-MONOMER.

Protein family/group databases

TCDBi2.A.64.3.1. the twin arginine targeting (tat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sec-independent protein translocase protein TatAdUniRule annotation
Gene namesi
Name:tatAdUniRule annotation
Synonyms:yczB
Ordered Locus Names:BSU02630
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000979811 – 70Sec-independent protein translocase protein TatAdAdd BLAST70

Proteomic databases

PaxDbiO31467.

Expressioni

Inductioni

Expressed under conditions of phosphate starvation.

Interactioni

Subunit structurei

Forms a complex with TatCd. Two types of complexes exist: one composed of TatAd and TatCd, and another composed only of TatAd. Soluble TatAd forms homomultimers bigger than 100 kDa. Soluble TatAd associates in homomultimeric micelle-like particles with a size of about 12 or 25 nm in diameter as well as in elongated particles of 12 nm in diameter.UniRule annotation2 Publications

Protein-protein interaction databases

IntActiO31467. 20 interactors.
STRINGi224308.Bsubs1_010100001463.

Structurei

Secondary structure

170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Helixi7 – 20Combined sources14
Turni23 – 25Combined sources3
Helixi26 – 49Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L16NMR-A1-70[»]
SMRiO31467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TatA/E family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41067S4. Bacteria.
ENOG410XUF0. LUCA.
HOGENOMiHOG000245365.
InParanoidiO31467.
KOiK03116.
OMAiKKATREP.
PhylomeDBiO31467.

Family and domain databases

HAMAPiMF_00236. TatA_E. 1 hit.
InterProiIPR003369. TatA/B/E.
IPR006312. TatA/E.
IPR003998. TatB-like.
[Graphical view]
PfamiPF02416. MttA_Hcf106. 1 hit.
[Graphical view]
PRINTSiPR01506. TATBPROTEIN.
TIGRFAMsiTIGR01411. tatAE. 1 hit.

Sequencei

Sequence statusi: Complete.

O31467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSNIGIPGL ILIFVIALII FGPSKLPEIG RAAGRTLLEF KSATKSLVSG
60 70
DEKEEKSAEL TAVKQDKNAG
Length:70
Mass (Da):7,431
Last modified:November 3, 2009 - v2
Checksum:i3D6B356BC425D111
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB12057.2.
PIRiA69767.
RefSeqiNP_388145.2. NC_000964.3.
WP_003223835.1. NZ_JNCM01000030.1.

Genome annotation databases

EnsemblBacteriaiCAB12057; CAB12057; BSU02630.
GeneIDi11238161.
938398.
KEGGibsu:BSU02630.
PATRICi18972085. VBIBacSub10457_0271.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB12057.2.
PIRiA69767.
RefSeqiNP_388145.2. NC_000964.3.
WP_003223835.1. NZ_JNCM01000030.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L16NMR-A1-70[»]
SMRiO31467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO31467. 20 interactors.
STRINGi224308.Bsubs1_010100001463.

Protein family/group databases

TCDBi2.A.64.3.1. the twin arginine targeting (tat) family.

Proteomic databases

PaxDbiO31467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12057; CAB12057; BSU02630.
GeneIDi11238161.
938398.
KEGGibsu:BSU02630.
PATRICi18972085. VBIBacSub10457_0271.

Phylogenomic databases

eggNOGiENOG41067S4. Bacteria.
ENOG410XUF0. LUCA.
HOGENOMiHOG000245365.
InParanoidiO31467.
KOiK03116.
OMAiKKATREP.
PhylomeDBiO31467.

Enzyme and pathway databases

BioCyciBSUB:BSU02630-MONOMER.

Family and domain databases

HAMAPiMF_00236. TatA_E. 1 hit.
InterProiIPR003369. TatA/B/E.
IPR006312. TatA/E.
IPR003998. TatB-like.
[Graphical view]
PfamiPF02416. MttA_Hcf106. 1 hit.
[Graphical view]
PRINTSiPR01506. TATBPROTEIN.
TIGRFAMsiTIGR01411. tatAE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTATAD_BACSU
AccessioniPrimary (citable) accession number: O31467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 3, 2009
Last modified: November 2, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

B.subtilis possesses two minimal, substrate-specific, Tat translocases: TatAd-TatCd and TatAy-TatCy, each one composed of a TatA and a TatC protein. TatA is bifunctional and performs the function of both the TatA and TatB proteins of Gram-negative organisms.
Membrane-localization and maintenance of TatAd is assisted by TatCd.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.