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Protein

Tryptophan RNA-binding attenuator protein inhibitory protein

Gene

rtpA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

By forming a complex with tryptophan-activated TRAP, and masking its RNA binding site, it inhibits TRAP's RNA binding ability, thereby abolishing TRAP regulation of gene expression, leading to antitermination and increased trp operon expression. AT acts by competing with messenger RNA for the RNA binding domain of TRAP.

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciBSUB:BSU02530-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan RNA-binding attenuator protein inhibitory protein
Alternative name(s):
Anti-TRAP protein
Short name:
AT
Gene namesi
Name:rtpA
Synonyms:yczA
Ordered Locus Names:BSU02530
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975221 – 53Tryptophan RNA-binding attenuator protein inhibitory proteinAdd BLAST53

Proteomic databases

PaxDbiO31466

Expressioni

Inductioni

By uncharged Trp tRNA, via the T-box transcription antitermination mechanism.

Interactioni

Subunit structurei

Homopentamer or homohexamer.

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-48707N
IntActiO31466, 1 interactor
STRINGi224308.Bsubs1_010100001398

Structurei

Secondary structure

153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 8Combined sources4
Beta strandi9 – 11Combined sources3
Turni13 – 17Combined sources5
Beta strandi18 – 21Combined sources4
Turni27 – 31Combined sources5
Beta strandi32 – 36Combined sources5
Helixi38 – 50Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BX9X-ray2.80A/B/C/D/E/F/G/H/I/J/K/L1-53[»]
2KO8NMR-A/B/C1-53[»]
2ZP8X-ray3.20E/F/G/H/I/J1-53[»]
2ZP9X-ray3.20C/D/E/H/I/J/M/N/O1-53[»]
ProteinModelPortaliO31466
SMRiO31466
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO31466

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 19CXXCXGXG motif8
Repeati26 – 33CXXCXGXG motif8

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000008724
OMAiMVIATDD

Family and domain databases

InterProiView protein in InterPro
IPR031538 Anti-TRAP
IPR036410 HSP_DnaJ_Cys-rich_dom_sf
PfamiView protein in Pfam
PF15777 Anti-TRAP, 1 hit
SUPFAMiSSF57938 SSF57938, 1 hit

Sequencei

Sequence statusi: Complete.

O31466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIATDDLEV ACPKCERAGE IEGTPCPACS GKGVILTAQG YTLLDFIQKH

LNK
Length:53
Mass (Da):5,650
Last modified:January 1, 1998 - v1
Checksum:iE9956FB4FE0E7A85
GO

Mass spectrometryi

Molecular mass is 5648 Da from positions 1 - 53. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB12047.1
PIRiH69766
RefSeqiNP_388135.1, NC_000964.3
WP_003234807.1, NZ_JNCM01000030.1

Genome annotation databases

EnsemblBacteriaiCAB12047; CAB12047; BSU02530
GeneIDi938403
KEGGibsu:BSU02530
PATRICifig|224308.179.peg.261

Similar proteinsi

Entry informationi

Entry nameiRTPA_BACSU
AccessioniPrimary (citable) accession number: O31466
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health