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Protein

Fatty-acid peroxygenase

Gene

cypC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the alpha- and beta-hydroxylation of myristic acid in the presence of hydrogen peroxide.1 Publication

Catalytic activityi

Fatty acid + H2O2 = 3- or 2-hydroxy fatty acid + H2O.1 Publication

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi363 – 3631Iron (heme axial ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU02100-MONOMER.
MetaCyc:BSU02100-MONOMER.
BRENDAi1.11.2.4. 658.

Chemistry

SwissLipidsiSLP:000001181.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty-acid peroxygenase (EC:1.11.2.4)
Alternative name(s):
Cytochrome P450 152A1
Cytochrome P450BsBeta
Fatty acid beta-hydroxylase
Gene namesi
Name:cypC
Synonyms:CYP152A1
Ordered Locus Names:BSU02100
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Fatty-acid peroxygenasePRO_0000052235Add
BLAST

Proteomic databases

PaxDbiO31440.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100001173.

Structurei

Secondary structure

1
417
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 208Combined sources
Helixi21 – 233Combined sources
Helixi24 – 318Combined sources
Beta strandi34 – 418Combined sources
Beta strandi44 – 496Combined sources
Helixi52 – 587Combined sources
Turni61 – 633Combined sources
Helixi72 – 754Combined sources
Turni76 – 794Combined sources
Helixi84 – 863Combined sources
Helixi89 – 10113Combined sources
Helixi105 – 12622Combined sources
Beta strandi129 – 1335Combined sources
Helixi134 – 15017Combined sources
Turni156 – 1583Combined sources
Helixi159 – 17214Combined sources
Helixi178 – 20225Combined sources
Helixi213 – 2197Combined sources
Helixi230 – 24516Combined sources
Helixi247 – 26014Combined sources
Helixi263 – 2697Combined sources
Helixi273 – 28614Combined sources
Beta strandi292 – 2976Combined sources
Beta strandi301 – 3033Combined sources
Beta strandi306 – 3083Combined sources
Beta strandi313 – 3175Combined sources
Helixi318 – 3225Combined sources
Turni325 – 3273Combined sources
Beta strandi328 – 3303Combined sources
Helixi336 – 3394Combined sources
Beta strandi346 – 3483Combined sources
Beta strandi359 – 3613Combined sources
Helixi366 – 38217Combined sources
Beta strandi384 – 3874Combined sources
Beta strandi397 – 4015Combined sources
Beta strandi409 – 4157Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IZOX-ray2.10A/B/C1-417[»]
2ZQJX-ray2.90A/B/C1-417[»]
2ZQXX-ray2.37A/B/C1-417[»]
ProteinModelPortaliO31440.
SMRiO31440. Positions 6-416.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO31440.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiENOG4107E6A. Bacteria.
COG2124. LUCA.
HOGENOMiHOG000099453.
InParanoidiO31440.
KOiK15629.
OMAiNRTERYN.
PhylomeDBiO31440.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Complete.

O31440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEQIPHDKS LDNSLTLLKE GYLFIKNRTE RYNSDLFQAR LLGKNFICMT
60 70 80 90 100
GAEAAKVFYD TDRFQRQNAL PKRVQKSLFG VNAIQGMDGS AHIHRKMLFL
110 120 130 140 150
SLMTPPHQKR LAELMTEEWK AAVTRWEKAD EVVLFEEAKE ILCRVACYWA
160 170 180 190 200
GVPLKETEVK ERADDFIDMV DAFGAVGPRH WKGRRARPRA EEWIEVMIED
210 220 230 240 250
ARAGLLKTTS GTALHEMAFH TQEDGSQLDS RMAAIELINV LRPIVAISYF
260 270 280 290 300
LVFSALALHE HPKYKEWLRS GNSREREMFV QEVRRYYPFG PFLGALVKKD
310 320 330 340 350
FVWNNCEFKK GTSVLLDLYG TNHDPRLWDH PDEFRPERFA EREENLFDMI
360 370 380 390 400
PQGGGHAEKG HRCPGEGITI EVMKASLDFL VHQIEYDVPE QSLHYSLARM
410
PSLPESGFVM SGIRRKS
Length:417
Mass (Da):48,109
Last modified:January 1, 1998 - v1
Checksum:i252C0684E85CDCED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006424 Genomic DNA. Translation: BAA33107.1.
AL009126 Genomic DNA. Translation: CAB12004.1.
PIRiC69748.
RefSeqiNP_388092.1. NC_000964.3.
WP_003246284.1. NZ_JNCM01000030.1.

Genome annotation databases

EnsemblBacteriaiCAB12004; CAB12004; BSU02100.
GeneIDi938449.
KEGGibsu:BSU02100.
PATRICi18971965. VBIBacSub10457_0211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006424 Genomic DNA. Translation: BAA33107.1.
AL009126 Genomic DNA. Translation: CAB12004.1.
PIRiC69748.
RefSeqiNP_388092.1. NC_000964.3.
WP_003246284.1. NZ_JNCM01000030.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IZOX-ray2.10A/B/C1-417[»]
2ZQJX-ray2.90A/B/C1-417[»]
2ZQXX-ray2.37A/B/C1-417[»]
ProteinModelPortaliO31440.
SMRiO31440. Positions 6-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100001173.

Chemistry

SwissLipidsiSLP:000001181.

Proteomic databases

PaxDbiO31440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12004; CAB12004; BSU02100.
GeneIDi938449.
KEGGibsu:BSU02100.
PATRICi18971965. VBIBacSub10457_0211.

Phylogenomic databases

eggNOGiENOG4107E6A. Bacteria.
COG2124. LUCA.
HOGENOMiHOG000099453.
InParanoidiO31440.
KOiK15629.
OMAiNRTERYN.
PhylomeDBiO31440.

Enzyme and pathway databases

BioCyciBSUB:BSU02100-MONOMER.
MetaCyc:BSU02100-MONOMER.
BRENDAi1.11.2.4. 658.

Miscellaneous databases

EvolutionaryTraceiO31440.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
SUPFAMiSSF48264. SSF48264. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCYPC_BACSU
AccessioniPrimary (citable) accession number: O31440
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.