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O31422

- SKFA_BACSU

UniProt

O31422 - SKFA_BACSU

Protein

Sporulation-killing factor SkfA

Gene

skfA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation. Can also inhibit growth of other bacteria at high concentrations. Has a role in protecting the secreted lipase LipA against proteolysis, either by modulating its folding or by acting as a protease inhibitor.2 Publications

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial

    Enzyme and pathway databases

    BioCyciBSUB:BSU01910-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sporulation-killing factor SkfA
    Gene namesi
    Name:skfA
    Synonyms:ybcO
    Ordered Locus Names:BSU01910
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU01910. [Micado]

    Subcellular locationi

    Secreted
    Note: Secreted by the ABC transporter SkfEF.Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5555Sporulation-killing factor SkfAPRO_0000049459Add
    BLAST

    Proteomic databases

    PaxDbiO31422.

    Expressioni

    Inductioni

    By Spo0A and PhoP, during nutrient starvation, especially phosphate starvation. Repressed by AbrB during normal growth when nutrients are plentiful, in association with the transcriptional repressor Abh.3 Publications

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU01910.

    Family & Domainsi

    Phylogenomic databases

    OMAiPIETANE.

    Sequencei

    Sequence statusi: Complete.

    O31422-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRNQKEWES VSKKGLMKPG GTSIVKAAGC MGCWASKSIA MTRVCALPHP   50
    AMRAI 55
    Length:55
    Mass (Da):5,934
    Last modified:January 1, 1998 - v1
    Checksum:iF169E627ADBEBB55
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006424 Genomic DNA. Translation: BAA33086.1.
    AL009126 Genomic DNA. Translation: CAB11984.1.
    PIRiC69746.
    RefSeqiNP_388072.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB11984; CAB11984; BSU01910.
    GeneIDi938506.
    KEGGibsu:BSU01910.
    PATRICi38335271. VBIBacSub146942_0192.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    I'll have you for supper - Issue 90 of January 2008

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006424 Genomic DNA. Translation: BAA33086.1 .
    AL009126 Genomic DNA. Translation: CAB11984.1 .
    PIRi C69746.
    RefSeqi NP_388072.1. NC_000964.3.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU01910.

    Proteomic databases

    PaxDbi O31422.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB11984 ; CAB11984 ; BSU01910 .
    GeneIDi 938506.
    KEGGi bsu:BSU01910.
    PATRICi 38335271. VBIBacSub146942_0192.

    Organism-specific databases

    GenoListi BSU01910. [Micado ]

    Phylogenomic databases

    OMAi PIETANE.

    Enzyme and pathway databases

    BioCyci BSUB:BSU01910-MONOMER.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the 70kb region between 17 and 23 degree of the Bacillus subtilis chromosome."
      Haga K., Liu H., Yasumoto K., Takahashi H., Yoshikawa H.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "A 3.1-kb genomic fragment of Bacillus subtilis encodes the protein inhibiting growth of Xanthomonas oryzae pv. oryzae."
      Lin D., Qu L.-J., Gu H., Chen Z.
      J. Appl. Microbiol. 91:1044-1050(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INHIBITION OF XANTHOMONAS GROWTH.
    4. Cited for: FUNCTION.
      Strain: 168 / PY79.
    5. "Genes involved in SkfA killing factor production protect a Bacillus subtilis lipase against proteolysis."
      Westers H., Braun P.G., Westers L., Antelmann H., Hecker M., Jongbloed J.D.H., Yoshikawa H., Tanaka T., van Dijl J.M., Quax W.J.
      Appl. Environ. Microbiol. 71:1899-1908(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: ROLE IN LIPASE PRODUCTION.
      Strain: 168.
    6. "High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis."
      Fujita M., Gonzalez-Pastor J.E., Losick R.
      J. Bacteriol. 187:1357-1368(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: REPRESSION BY ABRB.
    7. "Phosphate starvation induces the sporulation killing factor of Bacillus subtilis."
      Allenby N.E.E., Watts C.A., Homuth G., Pragai Z., Wipat A., Ward A.C., Harwood C.R.
      J. Bacteriol. 188:5299-5303(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
      Strain: 168.
    8. "Abh and AbrB control of Bacillus subtilis antimicrobial gene expression."
      Strauch M.A., Bobay B.G., Cavanagh J., Yao F., Wilson A., Le Breton Y.
      J. Bacteriol. 189:7720-7732(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: REPRESSION BY ABRB AND ABH.

    Entry informationi

    Entry nameiSKFA_BACSU
    AccessioniPrimary (citable) accession number: O31422
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

    External Data

    Dasty 3