Arginine repressor - Bacillus stearothermophilus

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Reviewed, UniProtKB/Swiss-Prot O31408 (ARGR_BACST)

Last modified June 16, 2009. Version 61. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Arginine repressor

Gene names

Name:

argR

Organism

Bacillus stearothermophilus (Geobacillus stearothermophilus)

Taxonomic identifier

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Regulates arginine biosynthesis genes. HAMAP MF_00173
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis. [regulation] HAMAP MF_00173
Subunit structure	Homohexamer. HAMAP MF_00173
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the argR family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis Transcription Transcription regulation
Cellular component	Cytoplasm
Ligand	DNA-binding
Molecular function	Repressor
Technical term	3D-structure
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

149

Arginine repressor HAMAP MF_00173

PRO_0000205071

Secondary structure

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149

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

O31408-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: F15E1ACD89E006E8
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149

16,805

        10         20         30         40         50         60 
MNKGQRHIKI REIIMSNDIE TQDELVDRLR EAGFNVTQAT VSRDIKEMQL VKVPMANGRY 

        70         80         90        100        110        120 
KYSLPSDQRF NPLQKLKRAL VDVFIKLDGT GNLLVLRTLP GNAHAIGVLL DNLDWDEIVG 

       130        140 
TICGDDTCLI ICRTPKDAKK VSNQLLSML

References

[1]	"The highly thermostable arginine repressor of Bacillus stearothermophilus: gene cloning and repressor-operator interactions." Dion M., Charlier D.R.M., Wang H., Gigot D., Savchenko A., Hallet J.-N., Glansdorff N., Sakanyan V. Mol. Microbiol. 25:385-398(1997) [PubMed: 9282750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NCIB 8224 / CCM 2186.
[2]	"Structure of the arginine repressor from Bacillus stearothermophilus." Ni J., Sakanyan V., Charlier D., Glansdorff N., van Duyne G.D. Nat. Struct. Biol. 6:427-432(1999) [PubMed: 10331868] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).

Cross-references

Sequence databases

Y09546 Genomic DNA. Translation: CAA70737.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1B4A	X-ray	2.50	A/B/C/D/E/F	2-149	[»]
1B4B	X-ray	2.20	A/B/C	79-149	[»]

ModBase

Family and domain databases

HAMAP

MF_00173.
[Tree]

InterPro

IPR001669. Arg_repress.
IPR011991. Wing_hlx_DNA_bd.
[Graphical view]

Gene3D

G3DSA:3.30.1360.40. Arg_repress. 1 hit.
G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.

Pfam

PF01316. Arg_repressor. 1 hit.
PF02863. Arg_repressor_C. 1 hit.
[Graphical view]

PRINTS

PR01467. ARGREPRESSOR.

ProDom

PD007402. Arg_repress. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR01529. argR_whole. 1 hit.

ProtoNet

Entry information

Entry name

ARGR_BACST

Accession

Primary (citable) accession number: O31408

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents