O31408 (ARGR_GEOSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine repressor

Gene names

Name:

argR

Organism

Geobacillus stearothermophilus (Bacillus stearothermophilus)

Taxonomic identifier

1422 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates arginine biosynthesis genes. HAMAP MF_00173
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis. [regulation] HAMAP MF_00173
Subunit structure	Homohexamer.
Subcellular location	Cytoplasm Probable HAMAP MF_00173.
Sequence similarities	Belongs to the ArgR family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis Transcription Transcription regulation
Cellular component	Cytoplasm
Ligand	DNA-binding
Molecular function	Repressor
Technical term	3D-structure
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 149

149

Arginine repressor HAMAP MF_00173

PRO_0000205071

Secondary structure

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149

Helix Strand Turn

Details...

Helix

5 – 16

12

Helix

22 – 31

10

Helix

38 – 47

10

Beta strand

51 – 54

4

Beta strand

56 – 58

3

Beta strand

60 – 63

4

Beta strand

68 – 70

3

Helix

80 – 83

4

Beta strand

84 – 90

7

Beta strand

93 – 99

7

Helix

103 – 113

11

Beta strand

118 – 123

6

Beta strand

125 – 134

10

Helix

135 – 146

12

Sequences

	Sequence		Length	Mass (Da)
	O31408 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: F15E1ACD89E006E8	FASTA	149	16,805
	10 20 30 40 50 60 MNKGQRHIKI REIIMSNDIE TQDELVDRLR EAGFNVTQAT VSRDIKEMQL VKVPMANGRY 70 80 90 100 110 120 KYSLPSDQRF NPLQKLKRAL VDVFIKLDGT GNLLVLRTLP GNAHAIGVLL DNLDWDEIVG 130 140 TICGDDTCLI ICRTPKDAKK VSNQLLSML

References

[1]	"The highly thermostable arginine repressor of Bacillus stearothermophilus: gene cloning and repressor-operator interactions." Dion M., Charlier D.R.M., Wang H., Gigot D., Savchenko A., Hallet J.-N., Glansdorff N., Sakanyan V. Mol. Microbiol. 25:385-398(1997) [PubMed: 9282750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NCIMB 8224 / CCM 2186 / VKM B-718.
[2]	"Structure of the arginine repressor from Bacillus stearothermophilus." Ni J., Sakanyan V., Charlier D., Glansdorff N., van Duyne G.D. Nat. Struct. Biol. 6:427-432(1999) [PubMed: 10331868] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Y09546 Genomic DNA. Translation: CAA70737.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1B4A	X-ray	2.50	A/B/C/D/E/F	2-149	[»]
1B4B	X-ray	2.20	A/B/C	79-149	[»]

ProteinModelPortal

O31408.

SMR

O31408. Positions 4-149.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

HAMAP

MF_00173. Arg_repressor.
[Tree]

InterPro

IPR001669. Arg_repress.
IPR020899. Arg_repress_C.
IPR020900. Arg_repress_DNA-bd.
IPR011991. WHTH_trsnscrt_rep_DNA-bd.
[Graphical view]

Gene3D

G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.

Pfam

PF01316. Arg_repressor. 1 hit.
PF02863. Arg_repressor_C. 1 hit.
[Graphical view]

PRINTS

PR01467. ARGREPRESSOR.

ProDom

PD007402. Arg_repress. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF55252. Arg_repress. 1 hit.

TIGRFAMs

TIGR01529. ArgR_whole. 1 hit.

ProtoNet

Search...

Entry information

Entry name

ARGR_GEOSE

Accession

Primary (citable) accession number: O31408

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program