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Protein

3-carboxy-cis,cis-muconate cycloisomerase

Gene

pcaB

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes an anti cycloisomerization.

Catalytic activityi

2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = cis,cis-butadiene-1,2,4-tricarboxylate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
3-carboxy-cis,cis-muconate cycloisomerase (EC:5.5.1.2)
Alternative name(s):
3-carboxymuconate lactonizing enzyme
Short name:
CMLE
Gene namesi
Name:pcaB
Ordered Locus Names:blr5667
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001613481 – 4513-carboxy-cis,cis-muconate cycloisomeraseAdd BLAST451

Interactioni

Protein-protein interaction databases

STRINGi224911.blr5667.

Structurei

3D structure databases

ProteinModelPortaliO31385.
SMRiO31385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II fumarase/aspartase family.Curated

Phylogenomic databases

eggNOGiENOG4107RAW. Bacteria.
COG0015. LUCA.
HOGENOMiHOG000033914.
InParanoidiO31385.
KOiK01857.
OMAiLMIRLKA.
OrthoDBiPOG091H0168.
PhylomeDBiO31385.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR012789. Protocat_PcaB.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SMARTiSM00998. ADSL_C. 1 hit.
[Graphical view]
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR02426. protocat_pcaB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O31385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTALSPLLA PMLSSAAMRA ACDDRSTLQN MLDFEAALAR AEAATGVIPA
60 70 80 90 100
AAVGPIETAC KAATFDIAAL AEAATRSGNL AIPLVKALTA NVAKADAEAA
110 120 130 140 150
RYVHWGATSQ DVIDTATMLT LRAAIDALDA DLSRAIKGFA ALARNHRNTA
160 170 180 190 200
MVARTWLQHA LPMPFGLKAA EYAASLARAR CRLRRLSRDG LALQFGGAAG
210 220 230 240 250
TLAALGDKGL VVAERLAQEL NLPLPEAPWH THRDRIAEAA SALAILAGSC
260 270 280 290 300
GKIARDVSLM MQTDVAEAFE PAGEGRGGSS TMPHKRNPVA AASALGCATM
310 320 330 340 350
APQLAATIFA AQVQDHERSA GPWHAEWPTL PQLMLVTSGA LAAIVDIAEG
360 370 380 390 400
LDVDAARMRS NLDATHGLIM AEAVTFALAE RIGKSDAHHL IEAASKRAVA
410 420 430 440 450
EKKHLREVLA ADSQVTAHLS PEKIAALFEP MAYQGASQAM IDRLLDSLER

D
Length:451
Mass (Da):47,238
Last modified:January 1, 1998 - v1
Checksum:iDB6220DA9C5E1981
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10223 Genomic DNA. Translation: CAA71270.1.
BA000040 Genomic DNA. Translation: BAC50932.1.
RefSeqiNP_772307.1. NC_004463.1.
WP_011088413.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC50932; BAC50932; BAC50932.
GeneIDi1050271.
KEGGibja:blr5667.
PATRICi21195082. VBIBraJap65052_5776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10223 Genomic DNA. Translation: CAA71270.1.
BA000040 Genomic DNA. Translation: BAC50932.1.
RefSeqiNP_772307.1. NC_004463.1.
WP_011088413.1. NC_004463.1.

3D structure databases

ProteinModelPortaliO31385.
SMRiO31385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.blr5667.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC50932; BAC50932; BAC50932.
GeneIDi1050271.
KEGGibja:blr5667.
PATRICi21195082. VBIBraJap65052_5776.

Phylogenomic databases

eggNOGiENOG4107RAW. Bacteria.
COG0015. LUCA.
HOGENOMiHOG000033914.
InParanoidiO31385.
KOiK01857.
OMAiLMIRLKA.
OrthoDBiPOG091H0168.
PhylomeDBiO31385.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR012789. Protocat_PcaB.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SMARTiSM00998. ADSL_C. 1 hit.
[Graphical view]
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR02426. protocat_pcaB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCAB_BRADU
AccessioniPrimary (citable) accession number: O31385
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.