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Protein

Holo-[acyl-carrier-protein] synthase

Gene

PPT1

Organism
Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotationSAAS annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi13MagnesiumUniRule annotation1
Binding sitei13Coenzyme ACombined sources1
Binding sitei46Coenzyme ACombined sources1
Binding sitei65Coenzyme ACombined sources1
Binding sitei69Coenzyme ACombined sources1
Metal bindingi74MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotationImported
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:PPT1Imported
Synonyms:acpSUniRule annotation
OrganismiCorynebacterium ammoniagenes (Brevibacterium ammoniagenes)Imported
Taxonomic identifieri1697 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NE9X-ray2.50A/B/C1-153[»]
3NFDX-ray1.89A/B/C/D/E/F1-153[»]
ProteinModelPortaliO31302
SMRiO31302
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO31302

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 145ACPSInterPro annotationAdd BLAST136

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni78 – 81Coenzyme A bindingCombined sources4
Regioni108 – 109Coenzyme A bindingCombined sources2
Regioni136 – 138Coenzyme A bindingCombined sources3

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105R3C Bacteria
COG0736 LUCA

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00556 pantethn_trn, 1 hit

Sequencei

Sequence statusi: Complete.

O31302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDNREAMTV GVDLVHIPGF AEQLSRPGST FEQVFSPLER RHAQTRRDAA
60 70 80 90 100
ADATNSSLAG SRTEHLAGRW AAKEAFIKAW SQAIYGKPPV IEPDLVNFAE
110 120 130 140 150
IEVLPDRWGR VALQLKGEVA AKLQESIGDV ELALSISHDG DYATAQCLLR

YQR
Length:153
Mass (Da):16,885
Last modified:January 1, 1998 - v1
Checksum:iADE208DDE34EEE00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15081 Genomic DNA Translation: CAA75358.1

Similar proteinsi

Entry informationi

Entry nameiO31302_CORAM
AccessioniPrimary (citable) accession number: O31302
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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