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Protein

Holo-[acyl-carrier-protein] synthase

Gene

PPT1

Organism
Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotationSAAS annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131MagnesiumUniRule annotation
Binding sitei13 – 131Coenzyme ACombined sources
Binding sitei65 – 651Coenzyme ACombined sources
Binding sitei69 – 691Coenzyme ACombined sources
Metal bindingi74 – 741MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Fatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotationSAAS annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:PPT1Imported
Synonyms:acpSUniRule annotation
OrganismiCorynebacterium ammoniagenes (Brevibacterium ammoniagenes)Imported
Taxonomic identifieri1697 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi649754.HMPREF0281_01213.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NE9X-ray2.50A/B/C1-153[»]
3NFDX-ray1.89A/B/C/D/E/F1-153[»]
ProteinModelPortaliO31302.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO31302.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 145136ACPSInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni78 – 814Coenzyme A bindingCombined sources
Regioni108 – 1092Coenzyme A bindingCombined sources
Regioni136 – 1383Coenzyme A bindingCombined sources

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105R3C. Bacteria.
COG0736. LUCA.

Family and domain databases

Gene3Di3.90.470.20. 1 hit.
HAMAPiMF_00101. AcpS. 1 hit.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. Ppantetheine-prot_Trfase_dom.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
ProDomiPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56214. SSF56214. 1 hit.
TIGRFAMsiTIGR00556. pantethn_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

O31302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDNREAMTV GVDLVHIPGF AEQLSRPGST FEQVFSPLER RHAQTRRDAA
60 70 80 90 100
ADATNSSLAG SRTEHLAGRW AAKEAFIKAW SQAIYGKPPV IEPDLVNFAE
110 120 130 140 150
IEVLPDRWGR VALQLKGEVA AKLQESIGDV ELALSISHDG DYATAQCLLR

YQR
Length:153
Mass (Da):16,885
Last modified:January 1, 1998 - v1
Checksum:iADE208DDE34EEE00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15081 Genomic DNA. Translation: CAA75358.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15081 Genomic DNA. Translation: CAA75358.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NE9X-ray2.50A/B/C1-153[»]
3NFDX-ray1.89A/B/C/D/E/F1-153[»]
ProteinModelPortaliO31302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi649754.HMPREF0281_01213.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105R3C. Bacteria.
COG0736. LUCA.

Miscellaneous databases

EvolutionaryTraceiO31302.

Family and domain databases

Gene3Di3.90.470.20. 1 hit.
HAMAPiMF_00101. AcpS. 1 hit.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. Ppantetheine-prot_Trfase_dom.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
ProDomiPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56214. SSF56214. 1 hit.
TIGRFAMsiTIGR00556. pantethn_trn. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO31302_CORAM
AccessioniPrimary (citable) accession number: O31302
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.