Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 1

Gene

coxA

Organism
Anabaena sp.
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:coxAImported
OrganismiAnabaena sp.Imported
Taxonomic identifieri1167 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921HelicalUniRule annotationAdd
BLAST
Transmembranei79 – 10022HelicalUniRule annotationAdd
BLAST
Transmembranei121 – 14323HelicalUniRule annotationAdd
BLAST
Transmembranei163 – 19028HelicalUniRule annotationAdd
BLAST
Transmembranei202 – 23433HelicalUniRule annotationAdd
BLAST
Transmembranei254 – 27825HelicalUniRule annotationAdd
BLAST
Transmembranei290 – 30920HelicalUniRule annotationAdd
BLAST
Transmembranei321 – 34323HelicalUniRule annotationAdd
BLAST
Transmembranei355 – 37925HelicalUniRule annotationAdd
BLAST
Transmembranei391 – 41424HelicalUniRule annotationAdd
BLAST
Transmembranei426 – 44621HelicalUniRule annotationAdd
BLAST
Transmembranei474 – 49623HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Structurei

3D structure databases

ProteinModelPortaliO31253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 530513COX1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O31253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQAQLQETA NIPARIEEPG ERHWRDYFGF NTDHKVIGLQ YLVTSFIFYC
60 70 80 90 100
IGGVMADLVR TELRTPEVDF VSPEVYNSLF TLHATIMIFL WIVPAGAGFA
110 120 130 140 150
NYLIPLMIGA RDMAFPRLNA VAFWMIPPAG LLLIASLVVG DAPDAGWTSY
160 170 180 190 200
PPLSLVTGQV GEGIWIISVL LLGTSSILGA INFLVTLLKM RIPSMGFHQM
210 220 230 240 250
PLFCWAMFAT SALVLLSTPV LAAGLILLAF DLIAGTTFFN PTGGGDPVVY
260 270 280 290 300
QHMFWFYSHP AVYIMILPFF GAISEIIPIH SRKPIFGYKA IAYSSLAISF
310 320 330 340 350
LGLIVWAHHM FTSGIPGWLR MFFMITTMII AVPTGIKIFS WLATMWGGKI
360 370 380 390 400
QFNSAMLFAA GFVGTFVIGG VSGVMLAAVP FDIHVHDTYF VVAHLHYVLF
410 420 430 440 450
GGSVLGIFAA IYHWFPKMTG RMINEFWGKV HFALTIVGLN MTFLPMHKLG
460 470 480 490 500
LMGMNRRIAQ YDPKFTLLNE ICTYGSYILA VSTFPFIFNA IWSWLYGEKA
510 520 530 540 550
GNNPWRALTL EWMTTSPPAI ENFDKLPVLA TGPYDYGLEK ASEGVPLSDP
560 570
NPVLSAGPNS VLRAEPDEPY PTIES
Length:575
Mass (Da):63,626
Last modified:January 1, 1998 - v1
Checksum:i99B41B3E91623D2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98264 Genomic DNA. Translation: CAB10935.1.

Genome annotation databases

PATRICi35421436. VBIAnaVar43351_1289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98264 Genomic DNA. Translation: CAB10935.1.

3D structure databases

ProteinModelPortaliO31253.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

PATRICi35421436. VBIAnaVar43351_1289.

Phylogenomic databases

OrthoDBiEOG6B35XR.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The coxBAC operon encodes a cytochrome c oxidase required for heterotrophic growth in the cyanobacterium Anabaena variabilis strain ATCC 29413."
    Schmetterer G., Valladares A., Pils D., Steinbach S., Pacher M., Muro-Pastor A.M., Flores E., Herrero A.
    J. Bacteriol. 183:6429-6434(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC29413Imported.

Entry informationi

Entry nameiO31253_9NOST
AccessioniPrimary (citable) accession number: O31253
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.