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Protein

Alcohol dehydrogenase

Gene

adhA

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Zinc; catalyticBy similarity1
Metal bindingi63Zinc; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:adhA
Ordered Locus Names:RA0704
ORF Names:SMa1296
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607481 – 340Alcohol dehydrogenaseAdd BLAST340

Structurei

3D structure databases

ProteinModelPortaliO31186.
SMRiO31186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685.
KOiK13953.
OMAiQYAHNVF.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

O31186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMTAAVVRE FGKPLVIEEV PVPQPGPGQV LIKYEATGVC HTDLHAAKGD
60 70 80 90 100
WPVRPNPPFI PGHEGVGYVA KLGAEVTRLK EGDRVGVPWL HTACGCCTPC
110 120 130 140 150
RTGWETLCGS QQNTGYSVDG TFAQYGLADP DFVGRLPARL EFGPAAPVLC
160 170 180 190 200
AGVTVYKGLK ETEVRPGEWV LVSGIGGLGH MAVQYAKAMG MHVAAADIFP
210 220 230 240 250
DKLALAEKLG ADLVVDARAP DAVEEVQRRT GGLHGALVTA VSPKAMEQAY
260 270 280 290 300
SMLRSKGTMA LVGLPPGQIC LPVFDTVLKR ITVRGSIVGT RQDLEEALEF
310 320 330 340
AGEGKVAAHF SWDKIENINA IFERMEEGKI DGRIVLDLNG
Length:340
Mass (Da):36,235
Last modified:January 1, 1998 - v1
Checksum:iC1A04B5FEE5C95E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031940 Genomic DNA. Translation: AAB87463.1.
AE006469 Genomic DNA. Translation: AAK65362.1.
PIRiH95349.
RefSeqiNP_435950.1. NC_003037.1.
WP_010967682.1. NC_003037.1.

Genome annotation databases

EnsemblBacteriaiAAK65362; AAK65362; SMa1296.
GeneIDi1235740.
25012428.
KEGGisme:SMa1296.
PATRICifig|266834.11.peg.726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031940 Genomic DNA. Translation: AAB87463.1.
AE006469 Genomic DNA. Translation: AAK65362.1.
PIRiH95349.
RefSeqiNP_435950.1. NC_003037.1.
WP_010967682.1. NC_003037.1.

3D structure databases

ProteinModelPortaliO31186.
SMRiO31186.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK65362; AAK65362; SMa1296.
GeneIDi1235740.
25012428.
KEGGisme:SMa1296.
PATRICifig|266834.11.peg.726.

Phylogenomic databases

HOGENOMiHOG000294685.
KOiK13953.
OMAiQYAHNVF.

Miscellaneous databases

PROiPR:O31186.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADHA_RHIME
AccessioniPrimary (citable) accession number: O31186
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: June 7, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.