ID   FWDC_METMP              Reviewed;         272 AA.
AC   O31112;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   16-JUN-2009, entry version 57.
DE   RecName: Full=Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C;
DE            EC=1.2.99.5;
DE   AltName: Full=Tungsten-containing formylmethanofuran dehydrogenase II subunit C;
GN   Name=fwdC; OrderedLocusNames=MMP1249;
OS   Methanococcus maripaludis.
OC   Archaea; Euryarchaeota; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=39152;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=JJ;
RA   Yu J.-P., Whitman W.B.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S2 / LL;
RX   PubMed=15466049; DOI=10.1128/JB.186.20.6956-6969.2004;
RA   Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA   Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E.,
RA   Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J.,
RA   Major T.A., Moore B.C., Porat I., Palmeiri A., Rouse G.,
RA   Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B.,
RA   Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A.;
RT   "Complete genome sequence of the genetically tractable
RT   hydrogenotrophic methanogen Methanococcus maripaludis.";
RL   J. Bacteriol. 186:6956-6969(2004).
CC   -!- FUNCTION: Catalyzes the reversible oxidation of CO(2) and
CC       methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme
CC       is oxygen-labile (By similarity).
CC   -!- CATALYTIC ACTIVITY: Formylmethanofuran + H(2)O + acceptor = CO(2)
CC       + methanofuran + reduced acceptor.
CC   -!- COFACTOR: Tungsten (By similarity).
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from carbone
CC       dioxide; 5,10-methenyl-H(4)MPT from CO(2): step 1/3.
CC   -!- SUBUNIT: This enzyme is composed of seven subunits fwdA (65 kDa),
CC       fwdB (53 kDa), fwdC (31 kDa), fwdD (15 kDa), fwdE, fwdF and fwdG
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the fwdC/fmdC family.
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DR   EMBL; AF029842; AAB82591.1; -; Genomic_DNA.
DR   EMBL; BX950229; CAF30805.1; -; Genomic_DNA.
DR   RefSeq; NP_988369.1; -.
DR   GeneID; 2762780; -.
DR   GenomeReviews; BX950229_GR; MMP1249.
DR   KEGG; mmp:MMP1249; -.
DR   NMPDR; fig|267377.1.peg.1249; -.
DR   HOGENOM; O31112; -.
DR   OMA; O31112; YVGSAYR.
DR   BioCyc; MMAR267377:MMP1249-MON; -.
DR   BRENDA; 1.2.99.5; 20956.
DR   GO; GO:0018493; F:formylmethanofuran dehydrogenase activity; IEA:EC.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR017550; Formylmethanofuran_DH_suC.
DR   InterPro; IPR002489; Glu_synthase_C.
DR   Gene3D; G3DSA:2.160.20.60; Glu_synthase_C; 1.
DR   Pfam; PF01493; GXGXG; 1.
DR   TIGRFAMs; TIGR03122; one_C_dehyd_C; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Methanogenesis; Oxidoreductase; Repeat; Tungsten.
FT   CHAIN         1    272       Tungsten-containing formylmethanofuran
FT                                dehydrogenase 2 subunit C.
FT                                /FTId=PRO_0000144195.
FT   REPEAT       77     89       1.
FT   REPEAT       96    108       2.
FT   REPEAT      115    127       3.
FT   REPEAT      141    153       4.
FT   REPEAT      160    172       5.
FT   REPEAT      179    191       6.
FT   REPEAT      198    210       7.
FT   REGION       77    210       7 X 13 AA repeats of [GW]-X-X-[MLP]-X-X-
FT                                G-X-[IL]-X-[IV]-X-G.
FT   CONFLICT     22     22       L -> I (in Ref. 1; AAB82591).
FT   CONFLICT     33     33       E -> K (in Ref. 1; AAB82591).
FT   CONFLICT     60     62       DVA -> PVS (in Ref. 1; AAB82591).
FT   CONFLICT     95     95       I -> V (in Ref. 1; AAB82591).
FT   CONFLICT    154    154       N -> T (in Ref. 1; AAB82591).
FT   CONFLICT    182    182       Q -> P (in Ref. 1; AAB82591).
FT   CONFLICT    212    212       I -> T (in Ref. 1; AAB82591).
FT   CONFLICT    233    233       S -> F (in Ref. 1; AAB82591).
SQ   SEQUENCE   272 AA;  29187 MW;  F87AA3DE97D34DC0 CRC64;
     MNELILNLKG DVSVPVEMDK ILPEKIQEMS LEEISGIELI QGNKTAKVSE IFDVELKESD
     VAKVTINNCC KKVKRIGEKM TSGEIVVNGD AGMYIGVEMK GGKITVNGDA ESWVGQNLKG
     GEIIINGNAE NYVGSAYRGD WRGMSGGKIT ITGNAGSELG EYLKGGTIVI KGNTKIMPGI
     HQNGGMIIIE GDIEGRAGGE MMKGAIVVYG KILEPLPSFK FEGIVEDPLV KLSKKDAGTQ
     LKGTFIKFSG DYVNTKPKGQ LYAAIENNKN LI
//