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Reviewed, UniProtKB/Swiss-Prot O31067 (HEMN_THEVL)

Last modified June 16, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Oxygen-independent coproporphyrinogen-III oxidase
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase
    EC=1.3.99.22
Gene names
Name: hemN
OrganismThermosynechococcus vulcanus (Synechococcus vulcanus)
Taxonomic identifier32053 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaChroococcalesThermosynechococcus

Protein attributes

Sequence length325 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX By similarity.

Catalytic activity

Coproporphyrinogen-III + 2 S-adenosyl-L-methionine = protoporphyrinogen-IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine.

Cofactor

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1.

Subunit structure

Monomer.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the anaerobic coproporphyrinogen-III oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 325›325Oxygen-independent coproporphyrinogen-III oxidase
PRO_0000109953

Sites

Binding site131S-adenosyl-L-methionine 1 By similarity
Binding site401S-adenosyl-L-methionine 2 By similarity
Binding site521S-adenosyl-L-methionine 2 By similarity
Binding site771S-adenosyl-L-methionine 2 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
O31067-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: A4011FB51C67732B

FASTA32536,817
        10         20         30         40         50         60 
AFLMTKDAEI SIEVSPRYIN GDYFLRGRKL GFNRISFGVQ DFDPQVQLAV NRVQRETMFF 

        70         80         90        100        110        120 
QVMEWIRAAE FESVNIDLIY GLPYQTVQSF EATIAKTLRL DPDRIAVFNF AYLPNLKPIQ 

       130        140        150        160        170        180 
KRIDPTTLPD SATKLTILQR VIERLTSQGY RYIGMDHFAK PTDELAIAQR SGDLKRNFQG 

       190        200        210        220        230        240 
YTTLPTADLI GFGLTSISML QAAYAQNQKH LATYFSDVAA GHHGPQECGF NCTVEDLLRR 

       250        260        270        280        290        300 
TIIMELMCQF SLDKGAIARQ FNLDFDAYFA SELAALRELA ADGLLHLGRD RLEVTPVGRL 

       310        320 
LIRNITAVFD AYLQQKSGRT FSKAI 

« Hide

References

[1]Los D.A.
Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

AF027176 Genomic DNA. Translation: AAB84028.1.

3D structure databases

ModBaseSearch...

Enzyme and pathway databases

BRENDA1.3.99.22. 276791.

Family and domain databases

InterProIPR006638. Elp3/MiaB/NifB.
IPR004558. HemN.
IPR010723. HemN_C.
IPR007197. Radical_SAM.
[Graphical view]
PfamPF06969. HemN_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsTIGR00538. hemN. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEMN_THEVL
AccessionPrimary (citable) accession number: O31067
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents