O31067 (HEMN_THEVL) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 62.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Oxygen-independent coproporphyrinogen-III oxidase Short name=Coprogen oxidase Short name=Coproporphyrinogenase EC=1.3.99.22 | ||
| Gene names |
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| Organism | Thermosynechococcus vulcanus (Synechococcus vulcanus) | ||
| Taxonomic identifier | 32053 [NCBI] | ||
| Taxonomic lineage | Bacteria › Cyanobacteria › Chroococcales › Thermosynechococcus |
Protein attributes
| Sequence length | 325 AA. |
| Sequence status | Fragment. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX By similarity. |
| Catalytic activity | Coproporphyrinogen-III + 2 S-adenosyl-L-methionine = protoporphyrinogen-IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine. |
| Cofactor | Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity. |
| Pathway | |
| Subunit structure | Monomer. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the anaerobic coproporphyrinogen-III oxidase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Porphyrin biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | 4Fe-4S Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW coproporphyrinogen dehydrogenase activityInferred from electronic annotation. Source: EC coproporphyrinogen oxidase activityInferred from electronic annotation. Source: InterPro metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | ‹1 – 325 | ›325 | Oxygen-independent coproporphyrinogen-III oxidase | PRO_0000109953 | |||||
Sites | |||||||||
| Binding site | 13 | 1 | S-adenosyl-L-methionine 1 By similarity | ||||||
| Binding site | 40 | 1 | S-adenosyl-L-methionine 2 By similarity | ||||||
| Binding site | 52 | 1 | S-adenosyl-L-methionine 2 By similarity | ||||||
| Binding site | 77 | 1 | S-adenosyl-L-methionine 2 By similarity | ||||||
Experimental info | |||||||||
| Non-terminal residue | 1 | 1 | |||||||
Sequences
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References
| [1] | Los D.A. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF027176 Genomic DNA. Translation: AAB84028.1. |
3D structure databases | |
| ProteinModelPortal | O31067. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR004558. Coprogen_oxidase_HemN. IPR006638. Elp3/MiaB/NifB. IPR010723. HemN_C. IPR023404. rSAM_horseshoe. [Graphical view] |
| Gene3D | G3DSA:3.80.30.20. G3DSA:3.80.30.20. 1 hit. |
| Pfam | PF06969. HemN_C. 1 hit. [Graphical view] |
| SMART | SM00729. Elp3. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00538. HemN. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HEMN_THEVL | ||||||||
| Accession | Primary (citable) accession number: O31067 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with