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Protein

Catalase-peroxidase

Gene

katG

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity (By similarity). Important for stationary phase survival.UniRule annotation1 Publication

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei92Transition state stabilizerUniRule annotation1
Active sitei96Proton acceptorUniRule annotation1
Metal bindingi258Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.11.1.21 1218

Protein family/group databases

PeroxiBasei2349 CcrCP01

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:CC_3043
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000555681 – 727Catalase-peroxidaseAdd BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki95 ↔ 217Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-243)UniRule annotation
Cross-linki217 ↔ 243Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiO31066

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_3043

Structurei

3D structure databases

ProteinModelPortaliO31066
SMRiO31066
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiPEEDIYW

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

O31066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKVEDNIA GKCPMGHGRG PANRDWWPQS LRLEGLNQHA PRSNPMGEAF
60 70 80 90 100
DYAEAFKSLD LDAVVSDLHA LMTDSQEWWP ADFGHYGGLF IRLAWHAAGT
110 120 130 140 150
YRITDGRGGA GGGQQRFAPL NSWPDNTNLD KARRLLWPIK QKYGAKLSWA
160 170 180 190 200
DLYVLVGNVA LESMGFKTFG FAGGRADQWE PEELYWGPES TWLDDKRYSG
210 220 230 240 250
ERELDSPLGA VQMGLIYVNP EGPNGNPDPL ASARDIRETF ARMAMNDEET
260 270 280 290 300
VALIAGGHTF GKAHGAGDAS LVGVEPEGGA IEAQGFGWAS KHGTGKGPDA
310 320 330 340 350
ITGGPEVIWT QTPTRWSNHF FDNLFKYEWE LTQSPAGAKQ WQAKNAPADI
360 370 380 390 400
PDAFDPNKTH VPRMLTSDLA LRFDPAYEKI SRRFYENPDQ FADAFARAWF
410 420 430 440 450
KLTHRDMGPI GRYLGPLVPK EELIWQDPIP AVDHPLADDK DIAALKAKIL
460 470 480 490 500
ATGLSASDLV STAWASASTY RQSDKRGGAN GARIRLAPQK DWAVNNPPVL
510 520 530 540 550
AKVLAALEGV QKDFNASAGG GKKISLADLI VLGGAAAIEK AAKDAGTSVT
560 570 580 590 600
VPFAPGRMDA SAEQTDAHSF EALEPRSDGF RNYRGPGKHY MAPEEALVDR
610 620 630 640 650
AQLLGLSGPE LTVLVGGLRV LGANADGSKD GVFTNRPGAL SNDFFVNLLS
660 670 680 690 700
METTWSPTAA NAFAGHDRKS SEPRWTATRV DLIFGSHAEL RAFAEVYACA
710 720
DSQEKFVCDF VTAWNKVMNA DRLDLAA
Length:727
Mass (Da):79,012
Last modified:November 25, 2008 - v3
Checksum:i8E6AB7EA0B930516
GO

Sequence cautioni

The sequence AAC45850 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAK25005 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK25005.1 Different initiation.
AF027168 Genomic DNA Translation: AAC45850.1 Different initiation.
PIRiA87626
T45480
RefSeqiNP_421837.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK25005; AAK25005; CC_3043
GeneIDi943888
KEGGiccr:CC_3043
PATRICifig|190650.5.peg.3047

Similar proteinsi

Entry informationi

Entry nameiKATG_CAUVC
AccessioniPrimary (citable) accession number: O31066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health