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Protein

Catalase-peroxidase

Gene

katG

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity (By similarity). Important for stationary phase survival.UniRule annotation1 Publication

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei92 – 921Transition state stabilizerUniRule annotation
Active sitei96 – 961Proton acceptorUniRule annotation
Metal bindingi258 – 2581Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.11.1.21. 1218.

Protein family/group databases

PeroxiBasei2349. CcrCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:CC_3043
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Catalase-peroxidasePRO_0000055568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki95 ↔ 217Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-243)UniRule annotation
Cross-linki217 ↔ 243Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiO31066.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_3043.

Structurei

3D structure databases

ProteinModelPortaliO31066.
SMRiO31066. Positions 20-726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O31066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKVEDNIA GKCPMGHGRG PANRDWWPQS LRLEGLNQHA PRSNPMGEAF
60 70 80 90 100
DYAEAFKSLD LDAVVSDLHA LMTDSQEWWP ADFGHYGGLF IRLAWHAAGT
110 120 130 140 150
YRITDGRGGA GGGQQRFAPL NSWPDNTNLD KARRLLWPIK QKYGAKLSWA
160 170 180 190 200
DLYVLVGNVA LESMGFKTFG FAGGRADQWE PEELYWGPES TWLDDKRYSG
210 220 230 240 250
ERELDSPLGA VQMGLIYVNP EGPNGNPDPL ASARDIRETF ARMAMNDEET
260 270 280 290 300
VALIAGGHTF GKAHGAGDAS LVGVEPEGGA IEAQGFGWAS KHGTGKGPDA
310 320 330 340 350
ITGGPEVIWT QTPTRWSNHF FDNLFKYEWE LTQSPAGAKQ WQAKNAPADI
360 370 380 390 400
PDAFDPNKTH VPRMLTSDLA LRFDPAYEKI SRRFYENPDQ FADAFARAWF
410 420 430 440 450
KLTHRDMGPI GRYLGPLVPK EELIWQDPIP AVDHPLADDK DIAALKAKIL
460 470 480 490 500
ATGLSASDLV STAWASASTY RQSDKRGGAN GARIRLAPQK DWAVNNPPVL
510 520 530 540 550
AKVLAALEGV QKDFNASAGG GKKISLADLI VLGGAAAIEK AAKDAGTSVT
560 570 580 590 600
VPFAPGRMDA SAEQTDAHSF EALEPRSDGF RNYRGPGKHY MAPEEALVDR
610 620 630 640 650
AQLLGLSGPE LTVLVGGLRV LGANADGSKD GVFTNRPGAL SNDFFVNLLS
660 670 680 690 700
METTWSPTAA NAFAGHDRKS SEPRWTATRV DLIFGSHAEL RAFAEVYACA
710 720
DSQEKFVCDF VTAWNKVMNA DRLDLAA
Length:727
Mass (Da):79,012
Last modified:November 25, 2008 - v3
Checksum:i8E6AB7EA0B930516
GO

Sequence cautioni

The sequence AAC45850 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAK25005 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK25005.1. Different initiation.
AF027168 Genomic DNA. Translation: AAC45850.1. Different initiation.
PIRiA87626.
T45480.
RefSeqiNP_421837.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK25005; AAK25005; CC_3043.
GeneIDi943888.
KEGGiccr:CC_3043.
PATRICi21303106. VBICauCre124313_3047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK25005.1. Different initiation.
AF027168 Genomic DNA. Translation: AAC45850.1. Different initiation.
PIRiA87626.
T45480.
RefSeqiNP_421837.1. NC_002696.2.

3D structure databases

ProteinModelPortaliO31066.
SMRiO31066. Positions 20-726.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_3043.

Protein family/group databases

PeroxiBasei2349. CcrCP01.

Proteomic databases

PRIDEiO31066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK25005; AAK25005; CC_3043.
GeneIDi943888.
KEGGiccr:CC_3043.
PATRICi21303106. VBICauCre124313_3047.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.

Enzyme and pathway databases

BRENDAi1.11.1.21. 1218.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_CAUCR
AccessioniPrimary (citable) accession number: O31066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.