Ornithine carbamoyltransferase, catabolic

Preferred order of sections

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3

Gene names

Name:

arcB

Organism

Rhizobium etli

Taxonomic identifier

29449 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 334

334

Ornithine carbamoyltransferase, catabolic HAMAP MF_01109

PRO_0000112996

Regions

Region

57 – 61

5

Carbamoyl phosphate binding By similarity

Region

273 – 276

4

Ornithine binding By similarity

Sites

Binding site

108

1

Carbamoyl phosphate By similarity

Binding site

135

1

Carbamoyl phosphate By similarity

Site

32

1

Important for structural integrity By similarity

Site

148

1

Important for structural integrity By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

O31018 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 21C5B2266048E159
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FASTA

334

37,817

        10         20         30         40         50         60 
MSFNLRNRSL LTVQDYTPRE FRYLLDLARD LKRAKYARTE QEHLKGKEIC LIFEKTSTRT 

        70         80         90        100        110        120 
RCAFEVACSD QGANVTYLDP SGSQIGHKES FKDTARVLGR MYDAIEYRGS AQKGVETLAK 

       130        140        150        160        170        180 
YAGVPVYNGL TDEYHPTQMI ADVMTMREHS DKPIAEIKYA YVGDTRSNMG HSLLIVGCLL 

       190        200        210        220        230        240 
GMDVRICGPR SLWPSEEYMK IAKVLQQASG ARLLVTEDPR EAVKDVDFIH TDVWVSMGEP 

       250        260        270        280        290        300 
KEVWRERIKL LTPYQVNQDL MKATGNPQTK FMHCLPAFHD TETTLGKQIA EDYGMDNGLE 

       310        320        330 
VTNDVFESEA NVAFEQAENR LHTIKALLVA TLGD

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References

[1]	"The arginine deiminase pathway in Rhizobium etli: DNA sequence analysis and functional study of the arcABC genes." D'Hooghe I., Vander Wauwe C., Michiels J., Tricot C., de Wilde P., Vanderleyden J., Stalon V. J. Bacteriol. 179:7403-7409(1997) [PubMed: 9393705] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF025543 Genomic DNA. Translation: AAC46019.1.
3D structure databases
ProteinModelPortal	O31018.
SMR	O31018. Positions 2-334.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_RHIET

Accession

Primary (citable) accession number: O31018

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families