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Protein

Intimin

Gene

eae

Organism
Escherichia coli O111:H-
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Necessary for the production of attaching and effacing lesions on tissue culture cells. Believed to mediate adherence.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Intimin
Alternative name(s):
Attaching and effacing protein
Short name:
Eae protein
Gene namesi
Name:eae
Synonyms:eaeA
OrganismiEscherichia coli O111:H-
Taxonomic identifieri168927 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 39HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002118261 – 935IntiminAdd BLAST935

Structurei

3D structure databases

ProteinModelPortaliO31000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 112LysMPROSITE-ProRule annotationAdd BLAST50
Domaini560 – 653Big-1 1PROSITE-ProRule annotationAdd BLAST94
Domaini660 – 754Big-1 2PROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Belongs to the intimin/invasin family.Curated
Contains 1 LysM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

CDDicd00118. LysM. 1 hit.
Gene3Di2.60.40.920. 2 hits.
3.10.100.10. 1 hit.
3.10.350.10. 1 hit.
InterProiIPR003344. Big_1_dom.
IPR003343. Big_2.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR024519. IAT_beta.
IPR003535. Intimin/invasin_bac.
IPR013117. Intimin_C.
IPR008964. Invasin/intimin_cell_adhesion.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF02369. Big_1. 1 hit.
PF02368. Big_2. 1 hit.
PF11924. IAT_beta. 1 hit.
PF07979. Intimin_C. 1 hit.
PF01476. LysM. 1 hit.
[Graphical view]
PRINTSiPR01369. INTIMIN.
SMARTiSM00634. BID_1. 2 hits.
SM00635. BID_2. 1 hit.
SM00257. LysM. 1 hit.
[Graphical view]
SUPFAMiSSF49373. SSF49373. 3 hits.
SSF56436. SSF56436. 1 hit.
PROSITEiPS51127. BIG1. 2 hits.
PS51782. LYSM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O31000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITHGFYART RHKHKLKKTF IMLSAGLGLF FYVNQNSFAN GENYFKLSSD
60 70 80 90 100
SKLLTQNVAQ DRLFYTLKTG ETVSSISKSQ GISLSVIWSL NKHLYSSESE
110 120 130 140 150
MLKAAPGQQI ILPLKKLSVE YGALPVLGSA PVVAAGGVAG HTNKMTKMSP
160 170 180 190 200
DATQSNMTDD RALNYTAQQA ASLGSQLQSR SLHGDYAKDT ALGIAGNQAS
210 220 230 240 250
SQLQAWLQHY GTAEVNLQSG NNFDGSSLDF LLPFYDSEKM LAFGQVGARY
260 270 280 290 300
IDSRFTANLG AGQRFFLPEN MLGYNVFIDQ DFSGDNTRLG IGGEYWRDYF
310 320 330 340 350
KSSVNGYFRM SGWHESYNKK DYDERPANGF DIRFNGYLPS YPALGAKLMY
360 370 380 390 400
EQYYGDNVAL FNSDKLQSNP GAATVGVNYT PIPLVTMGID YRHGTGYEND
410 420 430 440 450
LLYSMQFRYQ FDKPWSPQIE PQYVNELRTL SGSRYDLVQR NNNIILEYKK
460 470 480 490 500
QDILSLNIPH DINGTEHSTQ KIQLIVKSKY GLDRIVWDDS ALRSQGGQIQ
510 520 530 540 550
HSGSQSAQDY QAILPAYVQG GSNIYKVTAR AYDRNGNSSN NVQLTITVLS
560 570 580 590 600
NGQVVDQVGV TDFTADKTSA KADGTEAITY TATVKKNGVT QANVPVSFNI
610 620 630 640 650
VSGTATLGAN SATTDANGKA TVTLKSSTPG QVVVSAKTAE MTSALNASAV
660 670 680 690 700
IFVEQTKASI TEIKADKTTA VANGNDAVTY TVKVMKEGQP VHGHSVAFTT
710 720 730 740 750
NFGMFNGKSQ TQNATTGSDG RATITLTSSS AGKATVSATV SGGNDVKAPE
760 770 780 790 800
VTFFDGLKID NKVDILGKNV TGDLPNIWLQ YGQFKLKVSG GNGTYSWHSE
810 820 830 840 850
NTNIATVDES GKVTLKGKGT AVINVTSGDK QTVSYTIKAP NYMIRVGNKA
860 870 880 890 900
SYANAMSFCG NLLPSSQTVL SNVYNSWGPA NGYDHYRSMQ SITAWITQTE
910 920 930
ADKISGVSTT YDLITQNPHK DVSLNAPNVY AVCVE
Length:935
Mass (Da):101,570
Last modified:January 1, 1998 - v1
Checksum:i406E79CDC07DEB11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025311 Genomic DNA. Translation: AAC69247.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025311 Genomic DNA. Translation: AAC69247.1.

3D structure databases

ProteinModelPortaliO31000.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00118. LysM. 1 hit.
Gene3Di2.60.40.920. 2 hits.
3.10.100.10. 1 hit.
3.10.350.10. 1 hit.
InterProiIPR003344. Big_1_dom.
IPR003343. Big_2.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR024519. IAT_beta.
IPR003535. Intimin/invasin_bac.
IPR013117. Intimin_C.
IPR008964. Invasin/intimin_cell_adhesion.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF02369. Big_1. 1 hit.
PF02368. Big_2. 1 hit.
PF11924. IAT_beta. 1 hit.
PF07979. Intimin_C. 1 hit.
PF01476. LysM. 1 hit.
[Graphical view]
PRINTSiPR01369. INTIMIN.
SMARTiSM00634. BID_1. 2 hits.
SM00635. BID_2. 1 hit.
SM00257. LysM. 1 hit.
[Graphical view]
SUPFAMiSSF49373. SSF49373. 3 hits.
SSF56436. SSF56436. 1 hit.
PROSITEiPS51127. BIG1. 2 hits.
PS51782. LYSM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEAE_ECO11
AccessioniPrimary (citable) accession number: O31000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.