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Protein

Intimin

Gene

eae

Organism
Escherichia coli O111:H-
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Necessary for the production of attaching and effacing lesions on tissue culture cells. Believed to mediate adherence.

GO - Biological processi

Keywordsi

Biological processVirulence

Names & Taxonomyi

Protein namesi
Recommended name:
Intimin
Alternative name(s):
Attaching and effacing protein
Short name:
Eae protein
Gene namesi
Name:eae
Synonyms:eaeA
OrganismiEscherichia coli O111:H-
Taxonomic identifieri168927 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 39HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002118261 – 935IntiminAdd BLAST935

Proteomic databases

PRIDEiO31000

Structurei

3D structure databases

ProteinModelPortaliO31000
SMRiO31000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 112LysMPROSITE-ProRule annotationAdd BLAST50
Domaini560 – 653Big-1 1PROSITE-ProRule annotationAdd BLAST94
Domaini660 – 754Big-1 2PROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Belongs to the intimin/invasin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

CDDicd00118 LysM, 1 hit
Gene3Di2.40.160.160, 1 hit
2.60.40.10, 2 hits
3.10.100.10, 1 hit
3.10.350.10, 1 hit
InterProiView protein in InterPro
IPR003344 Big_1_dom
IPR003343 Big_2
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR024519 IAT_beta
IPR038177 IAT_beta_sf
IPR013783 Ig-like_fold
IPR003535 Intimin/invasin_bac
IPR013117 Intimin_C
IPR008964 Invasin/intimin_cell_adhesion
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
PfamiView protein in Pfam
PF02369 Big_1, 1 hit
PF02368 Big_2, 1 hit
PF11924 IAT_beta, 1 hit
PF07979 Intimin_C, 1 hit
PF01476 LysM, 1 hit
PRINTSiPR01369 INTIMIN
SMARTiView protein in SMART
SM00634 BID_1, 2 hits
SM00635 BID_2, 1 hit
SM00257 LysM, 1 hit
SUPFAMiSSF49373 SSF49373, 3 hits
SSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS51127 BIG1, 2 hits
PS51782 LYSM, 1 hit

Sequencei

Sequence statusi: Complete.

O31000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITHGFYART RHKHKLKKTF IMLSAGLGLF FYVNQNSFAN GENYFKLSSD
60 70 80 90 100
SKLLTQNVAQ DRLFYTLKTG ETVSSISKSQ GISLSVIWSL NKHLYSSESE
110 120 130 140 150
MLKAAPGQQI ILPLKKLSVE YGALPVLGSA PVVAAGGVAG HTNKMTKMSP
160 170 180 190 200
DATQSNMTDD RALNYTAQQA ASLGSQLQSR SLHGDYAKDT ALGIAGNQAS
210 220 230 240 250
SQLQAWLQHY GTAEVNLQSG NNFDGSSLDF LLPFYDSEKM LAFGQVGARY
260 270 280 290 300
IDSRFTANLG AGQRFFLPEN MLGYNVFIDQ DFSGDNTRLG IGGEYWRDYF
310 320 330 340 350
KSSVNGYFRM SGWHESYNKK DYDERPANGF DIRFNGYLPS YPALGAKLMY
360 370 380 390 400
EQYYGDNVAL FNSDKLQSNP GAATVGVNYT PIPLVTMGID YRHGTGYEND
410 420 430 440 450
LLYSMQFRYQ FDKPWSPQIE PQYVNELRTL SGSRYDLVQR NNNIILEYKK
460 470 480 490 500
QDILSLNIPH DINGTEHSTQ KIQLIVKSKY GLDRIVWDDS ALRSQGGQIQ
510 520 530 540 550
HSGSQSAQDY QAILPAYVQG GSNIYKVTAR AYDRNGNSSN NVQLTITVLS
560 570 580 590 600
NGQVVDQVGV TDFTADKTSA KADGTEAITY TATVKKNGVT QANVPVSFNI
610 620 630 640 650
VSGTATLGAN SATTDANGKA TVTLKSSTPG QVVVSAKTAE MTSALNASAV
660 670 680 690 700
IFVEQTKASI TEIKADKTTA VANGNDAVTY TVKVMKEGQP VHGHSVAFTT
710 720 730 740 750
NFGMFNGKSQ TQNATTGSDG RATITLTSSS AGKATVSATV SGGNDVKAPE
760 770 780 790 800
VTFFDGLKID NKVDILGKNV TGDLPNIWLQ YGQFKLKVSG GNGTYSWHSE
810 820 830 840 850
NTNIATVDES GKVTLKGKGT AVINVTSGDK QTVSYTIKAP NYMIRVGNKA
860 870 880 890 900
SYANAMSFCG NLLPSSQTVL SNVYNSWGPA NGYDHYRSMQ SITAWITQTE
910 920 930
ADKISGVSTT YDLITQNPHK DVSLNAPNVY AVCVE
Length:935
Mass (Da):101,570
Last modified:January 1, 1998 - v1
Checksum:i406E79CDC07DEB11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025311 Genomic DNA Translation: AAC69247.1

Entry informationi

Entry nameiEAE_ECO11
AccessioniPrimary (citable) accession number: O31000
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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