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O30917

- SIGE_SALTY

UniProt

O30917 - SIGE_SALTY

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Protein
Chaperone protein SigE
Gene
sigE, pipC, STM1090
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Molecular chaperone required for SopB/SigD stabilization and secretion.2 Publications

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1099-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein SigE
Gene namesi
Name:sigE
Synonyms:pipC
Ordered Locus Names:STM1090
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Chaperone protein SigE
PRO_0000160575Add
BLAST

Proteomic databases

PaxDbiO30917.
PRIDEiO30917.

Expressioni

Inductioni

Transcriptionally regulated by InvF and SicA. Also regulated by SirA.2 Publications

Interactioni

Subunit structurei

Homodimer or higher-order oligomers.

Protein-protein interaction databases

MINTiMINT-157122.
STRINGi99287.STM1090.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 118
Beta strandi24 – 263
Beta strandi29 – 357
Beta strandi37 – 4812
Helixi53 – 6513
Beta strandi66 – 727
Beta strandi78 – 869
Helixi91 – 11222

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K3SX-ray1.90A/B1-113[»]
ProteinModelPortaliO30917.
SMRiO30917. Positions 1-113.

Miscellaneous databases

EvolutionaryTraceiO30917.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG67978.
HOGENOMiHOG000028304.
OMAiLMLEMCC.
OrthoDBiEOG6KT2RR.

Family and domain databases

InterProiIPR013095. T3SS_chaperone.
[Graphical view]
PfamiPF07824. Chaperone_III. 1 hit.
[Graphical view]
PIRSFiPIRSF034754. T3SS_chaperone. 1 hit.
ProDomiPD030752. T3SS_chaperone. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

O30917-1 [UniParc]FASTAAdd to Basket

« Hide

MESLLNRLYD ALGLDAPEDE PLLIIDDGIQ VYFNESDHTL EMCCPFMPLP    50
DDILTLQHFL RLNYTSAVTI GADADNTALV ALYRLPQTST EEEALTGFEL 100
FISNVKQLKE HYA 113
Length:113
Mass (Da):12,751
Last modified:January 1, 1998 - v1
Checksum:i34DEE3AB3944560E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF021817 Genomic DNA. Translation: AAC46235.1.
AE006468 Genomic DNA. Translation: AAL20022.1.
RefSeqiNP_460063.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20022; AAL20022; STM1090.
GeneIDi1252608.
KEGGistm:STM1090.
PATRICi32380617. VBISalEnt20916_1154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF021817 Genomic DNA. Translation: AAC46235.1 .
AE006468 Genomic DNA. Translation: AAL20022.1 .
RefSeqi NP_460063.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K3S X-ray 1.90 A/B 1-113 [» ]
ProteinModelPortali O30917.
SMRi O30917. Positions 1-113.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-157122.
STRINGi 99287.STM1090.

Proteomic databases

PaxDbi O30917.
PRIDEi O30917.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20022 ; AAL20022 ; STM1090 .
GeneIDi 1252608.
KEGGi stm:STM1090.
PATRICi 32380617. VBISalEnt20916_1154.

Phylogenomic databases

eggNOGi NOG67978.
HOGENOMi HOG000028304.
OMAi LMLEMCC.
OrthoDBi EOG6KT2RR.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1099-MONOMER.

Miscellaneous databases

EvolutionaryTracei O30917.

Family and domain databases

InterProi IPR013095. T3SS_chaperone.
[Graphical view ]
Pfami PF07824. Chaperone_III. 1 hit.
[Graphical view ]
PIRSFi PIRSF034754. T3SS_chaperone. 1 hit.
ProDomi PD030752. T3SS_chaperone. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel Salmonella invasion locus homologous to Shigella ipgDE."
    Hong K.H., Miller V.L.
    J. Bacteriol. 180:1793-1802(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, REGULATION BY SIRA.
    Strain: ATCC 14028s / SGSG 2262.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  3. "The putative invasion protein chaperone SicA acts together with InvF to activate the expression of Salmonella typhimurium virulence genes."
    Darwin K.H., Miller V.L.
    Mol. Microbiol. 35:949-960(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION BY INVF AND SICA.
    Strain: ATCC 14028s / SGSG 2262, LT2 and SL1344.
  4. "SigE is a chaperone for the Salmonella enterica serovar Typhimurium invasion protein SigD."
    Darwin K.H., Robinson L.S., Miller V.L.
    J. Bacteriol. 183:1452-1454(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: ATCC 14028s / SGSG 2262.
  5. "Structural and biochemical characterization of the type III secretion chaperones CesT and SigE."
    Luo Y., Bertero M.G., Frey E.A., Pfuetzner R.A., Wenk M.R., Creagh L., Marcus S.L., Lim D., Sicheri F., Kay C., Haynes C., Finlay B.B., Strynadka N.C.J.
    Nat. Struct. Biol. 8:1031-1036(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).

Entry informationi

Entry nameiSIGE_SALTY
AccessioniPrimary (citable) accession number: O30917
Secondary accession number(s): Q7CQS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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