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Protein

Chaperone protein SigE

Gene

sigE

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone required for SopB/SigD stabilization and secretion.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein SigE
Gene namesi
Name:sigE
Synonyms:pipC
Ordered Locus Names:STM1090
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001605751 – 113Chaperone protein SigEAdd BLAST113

Proteomic databases

PaxDbiO30917.
PRIDEiO30917.

Expressioni

Inductioni

Transcriptionally regulated by InvF and SicA. Also regulated by SirA.

Interactioni

Subunit structurei

Homodimer or higher-order oligomers.

Protein-protein interaction databases

MINTiMINT-157122.
STRINGi99287.STM1090.

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 11Combined sources8
Beta strandi24 – 26Combined sources3
Beta strandi29 – 35Combined sources7
Beta strandi37 – 48Combined sources12
Helixi53 – 65Combined sources13
Beta strandi66 – 72Combined sources7
Beta strandi78 – 86Combined sources9
Helixi91 – 112Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K3SX-ray1.90A/B1-113[»]
ProteinModelPortaliO30917.
SMRiO30917.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO30917.

Family & Domainsi

Sequence similaritiesi

Belongs to the IpgE/SigE chaperone family.Curated

Phylogenomic databases

eggNOGiENOG4106HNN. Bacteria.
ENOG410Y459. LUCA.
HOGENOMiHOG000028304.
OMAiLMLEMCC.

Family and domain databases

InterProiIPR013095. T3SS_chaperone.
[Graphical view]
PfamiPF07824. Chaperone_III. 1 hit.
[Graphical view]
PIRSFiPIRSF034754. T3SS_chaperone. 1 hit.
ProDomiPD030752. T3SS_chaperone. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

O30917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLLNRLYD ALGLDAPEDE PLLIIDDGIQ VYFNESDHTL EMCCPFMPLP
60 70 80 90 100
DDILTLQHFL RLNYTSAVTI GADADNTALV ALYRLPQTST EEEALTGFEL
110
FISNVKQLKE HYA
Length:113
Mass (Da):12,751
Last modified:January 1, 1998 - v1
Checksum:i34DEE3AB3944560E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021817 Genomic DNA. Translation: AAC46235.1.
AE006468 Genomic DNA. Translation: AAL20022.1.
RefSeqiNP_460063.1. NC_003197.1.
WP_000444724.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20022; AAL20022; STM1090.
GeneIDi1252608.
KEGGistm:STM1090.
PATRICi32380617. VBISalEnt20916_1154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021817 Genomic DNA. Translation: AAC46235.1.
AE006468 Genomic DNA. Translation: AAL20022.1.
RefSeqiNP_460063.1. NC_003197.1.
WP_000444724.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K3SX-ray1.90A/B1-113[»]
ProteinModelPortaliO30917.
SMRiO30917.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-157122.
STRINGi99287.STM1090.

Proteomic databases

PaxDbiO30917.
PRIDEiO30917.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20022; AAL20022; STM1090.
GeneIDi1252608.
KEGGistm:STM1090.
PATRICi32380617. VBISalEnt20916_1154.

Phylogenomic databases

eggNOGiENOG4106HNN. Bacteria.
ENOG410Y459. LUCA.
HOGENOMiHOG000028304.
OMAiLMLEMCC.

Miscellaneous databases

EvolutionaryTraceiO30917.

Family and domain databases

InterProiIPR013095. T3SS_chaperone.
[Graphical view]
PfamiPF07824. Chaperone_III. 1 hit.
[Graphical view]
PIRSFiPIRSF034754. T3SS_chaperone. 1 hit.
ProDomiPD030752. T3SS_chaperone. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiSIGE_SALTY
AccessioniPrimary (citable) accession number: O30917
Secondary accession number(s): Q7CQS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.