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O30917

- SIGE_SALTY

UniProt

O30917 - SIGE_SALTY

Protein

Chaperone protein SigE

Gene

sigE

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Molecular chaperone required for SopB/SigD stabilization and secretion.2 Publications

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Virulence

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1099-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chaperone protein SigE
    Gene namesi
    Name:sigE
    Synonyms:pipC
    Ordered Locus Names:STM1090
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 113113Chaperone protein SigEPRO_0000160575Add
    BLAST

    Proteomic databases

    PaxDbiO30917.
    PRIDEiO30917.

    Expressioni

    Inductioni

    Transcriptionally regulated by InvF and SicA. Also regulated by SirA.

    Interactioni

    Subunit structurei

    Homodimer or higher-order oligomers.

    Protein-protein interaction databases

    MINTiMINT-157122.
    STRINGi99287.STM1090.

    Structurei

    Secondary structure

    1
    113
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 118
    Beta strandi24 – 263
    Beta strandi29 – 357
    Beta strandi37 – 4812
    Helixi53 – 6513
    Beta strandi66 – 727
    Beta strandi78 – 869
    Helixi91 – 11222

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K3SX-ray1.90A/B1-113[»]
    ProteinModelPortaliO30917.
    SMRiO30917. Positions 1-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO30917.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IpgE/SigE chaperone family.Curated

    Phylogenomic databases

    eggNOGiNOG67978.
    HOGENOMiHOG000028304.
    OMAiLMLEMCC.
    OrthoDBiEOG6KT2RR.

    Family and domain databases

    InterProiIPR013095. T3SS_chaperone.
    [Graphical view]
    PfamiPF07824. Chaperone_III. 1 hit.
    [Graphical view]
    PIRSFiPIRSF034754. T3SS_chaperone. 1 hit.
    ProDomiPD030752. T3SS_chaperone. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    O30917-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESLLNRLYD ALGLDAPEDE PLLIIDDGIQ VYFNESDHTL EMCCPFMPLP    50
    DDILTLQHFL RLNYTSAVTI GADADNTALV ALYRLPQTST EEEALTGFEL 100
    FISNVKQLKE HYA 113
    Length:113
    Mass (Da):12,751
    Last modified:January 1, 1998 - v1
    Checksum:i34DEE3AB3944560E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF021817 Genomic DNA. Translation: AAC46235.1.
    AE006468 Genomic DNA. Translation: AAL20022.1.
    RefSeqiNP_460063.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20022; AAL20022; STM1090.
    GeneIDi1252608.
    KEGGistm:STM1090.
    PATRICi32380617. VBISalEnt20916_1154.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF021817 Genomic DNA. Translation: AAC46235.1 .
    AE006468 Genomic DNA. Translation: AAL20022.1 .
    RefSeqi NP_460063.1. NC_003197.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K3S X-ray 1.90 A/B 1-113 [» ]
    ProteinModelPortali O30917.
    SMRi O30917. Positions 1-113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-157122.
    STRINGi 99287.STM1090.

    Proteomic databases

    PaxDbi O30917.
    PRIDEi O30917.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20022 ; AAL20022 ; STM1090 .
    GeneIDi 1252608.
    KEGGi stm:STM1090.
    PATRICi 32380617. VBISalEnt20916_1154.

    Phylogenomic databases

    eggNOGi NOG67978.
    HOGENOMi HOG000028304.
    OMAi LMLEMCC.
    OrthoDBi EOG6KT2RR.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-1099-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O30917.

    Family and domain databases

    InterProi IPR013095. T3SS_chaperone.
    [Graphical view ]
    Pfami PF07824. Chaperone_III. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF034754. T3SS_chaperone. 1 hit.
    ProDomi PD030752. T3SS_chaperone. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel Salmonella invasion locus homologous to Shigella ipgDE."
      Hong K.H., Miller V.L.
      J. Bacteriol. 180:1793-1802(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, REGULATION BY SIRA.
      Strain: ATCC 14028s / SGSG 2262.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    3. "The putative invasion protein chaperone SicA acts together with InvF to activate the expression of Salmonella typhimurium virulence genes."
      Darwin K.H., Miller V.L.
      Mol. Microbiol. 35:949-960(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: REGULATION BY INVF AND SICA.
      Strain: ATCC 14028s / SGSG 2262, LT2 and SL1344.
    4. "SigE is a chaperone for the Salmonella enterica serovar Typhimurium invasion protein SigD."
      Darwin K.H., Robinson L.S., Miller V.L.
      J. Bacteriol. 183:1452-1454(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: ATCC 14028s / SGSG 2262.
    5. "Structural and biochemical characterization of the type III secretion chaperones CesT and SigE."
      Luo Y., Bertero M.G., Frey E.A., Pfuetzner R.A., Wenk M.R., Creagh L., Marcus S.L., Lim D., Sicheri F., Kay C., Haynes C., Finlay B.B., Strynadka N.C.J.
      Nat. Struct. Biol. 8:1031-1036(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).

    Entry informationi

    Entry nameiSIGE_SALTY
    AccessioniPrimary (citable) accession number: O30917
    Secondary accession number(s): Q7CQS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3