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O30869

- T2H2_HAEAE

UniProt

O30869 - T2H2_HAEAE

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Protein
Type-2 restriction enzyme HaeII
Gene
haeIIR, dcrA
Organism
Haemophilus aegyptius
Status
Reviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Recognizes the double-stranded sequence RGCGCY and cleaves after C-5.

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

GO - Molecular functioni

  1. Type II site-specific deoxyribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Restriction system

Protein family/group databases

REBASEi1088. HaeII.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 restriction enzyme HaeII (EC:3.1.21.4)
Short name:
R.HaeII
Alternative name(s):
Endonuclease HaeII
Type II restriction enzyme HaeII
Gene namesi
Name:haeIIR
Synonyms:dcrA
OrganismiHaemophilus aegyptius
Taxonomic identifieri197575 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Type-2 restriction enzyme HaeII
PRO_0000077316Add
BLAST

Family & Domainsi

Family and domain databases

InterProiIPR019058. Restrct_endonuc_II_HaeII.
[Graphical view]
PfamiPF09554. RE_HaeII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O30869-1 [UniParc]FASTAAdd to Basket

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MNDIQVAKES LDKIIKKARV HLYKPIQIAE ILYQDRVNKN INLLDKETYR    50
NISKKWRDVI CIRFLGRVST SSAKYQDDLF NDNAMPPKHL NILGEMNRKT 100
NGGVESYIYK KFFERFNQMS SALEYSYSRT PDNFHLSEFL ALFWLEPGLK 150
RSIDKVYEIV VYALFSSLIE ALGVKVKIDL DLSNIDLLKE FEDFTRQIIS 200
LDSENTSLEL NAKINRVGVT NASDRGLDMW ANFGMAIQIK HLSLTEELAE 250
NIVSSVSSDR IVIVCKESEE KLILSLLNQI GWRSKIQSII TEADLIKWYD 300
KALRGKSAYL VGSKILEHIR NEINLEFPAT DIVDFNHFFH EREYNKALDI 350
EK 352
Length:352
Mass (Da):40,801
Last modified:January 1, 1998 - v1
Checksum:i3AE01F59FB1C289A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019752 Genomic DNA. Translation: AAB70830.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019752 Genomic DNA. Translation: AAB70830.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 1088. HaeII.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR019058. Restrct_endonuc_II_HaeII.
[Graphical view ]
Pfami PF09554. RE_HaeII. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence similarities between the genes encoding the S.NgoI and HaeII restriction/modification systems."
    Stein D.C., Gunn J.S., Piekarowicz A.
    Biol. Chem. 379:575-578(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 11116 / CCUG 25716 / NCTC 8502.

Entry informationi

Entry nameiT2H2_HAEAE
AccessioniPrimary (citable) accession number: O30869
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries

External Data

Dasty 3

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