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Protein

Modification methylase HaeII

Gene

haeIIM

Organism
Haemophilus aegyptius
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence RGCGCY, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the HaeII endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3409 M.HaeII

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase HaeII (EC:2.1.1.37)
Short name:
M.HaeII
Alternative name(s):
Cytosine-specific methyltransferase HaeII
Gene namesi
Name:haeIIM
Synonyms:dcmA
OrganismiHaemophilus aegyptius
Taxonomic identifieri197575 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878771 – 318Modification methylase HaeIIAdd BLAST318

Structurei

3D structure databases

ProteinModelPortaliO30868
SMRiO30868
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 304SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST301

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

O30868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEYKTIDLF AGIGGIRLGF EAFGCKNVFS SEWDKYAQSM YEVNFGEKPF
60 70 80 90 100
GDINDISPSD IPDHDILLAG FPCQPFSIAG KGLGFADTRG TLFFNIEAIL
110 120 130 140 150
KAKKPKAFLL ENVKRLTTHD NGNTFKVIND KLNKLGYTVY HKVLNTLDFG
160 170 180 190 200
LPQKRERIYI VGFLDKLHFE FPKPIGKYEE LSNILESDDV VPNNYFLSDE
210 220 230 240 250
LKRKRLSSIT KDVPYPSIWH ENISGNVSAL PYSCALSVGG SYNYLVVNGV
260 270 280 290 300
RRLTGPEMLR LQGFPDTFEI NIPYSQVRKV AGNSVSVPVI RAIAGSMINS
310
LNMATRKIYQ AIQLSLLD
Length:318
Mass (Da):35,670
Last modified:January 1, 1998 - v1
Checksum:iCA879CF66731D434
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019752 Genomic DNA Translation: AAB70829.1

Similar proteinsi

Entry informationi

Entry nameiMTH2_HAEAE
AccessioniPrimary (citable) accession number: O30868
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health