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O30853

- KPYK1_PHOLE

UniProt

O30853 - KPYK1_PHOLE

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Protein

Pyruvate kinase I

Gene

pki

Organism
Photobacterium leiognathi
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Substrate; via amide nitrogenBy similarity
Metal bindingi11 – 111MagnesiumBy similarity
Binding sitei11 – 111Substrate; via amide nitrogenBy similarity
Binding sitei43 – 431SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase I (EC:2.7.1.40)
Alternative name(s):
PK-1
Gene namesi
Name:pki
OrganismiPhotobacterium leiognathi
Taxonomic identifieri553611 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 235›235Pyruvate kinase IPRO_0000112083Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO30853.
SMRiO30853. Positions 1-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
SSF52935. SSF52935. 1 hit.

Sequencei

Sequence statusi: Fragment.

O30853-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ASDGIMVARG DLGVEIPVEE VIFAQKMMIE KCNRARKVVI TATQMLDSMI
60 70 80 90 100
KNPRPTRAEA GDVANAIMDG TDAVMLSGES AKGKYPIEAV TIMAQICART
110 120 130 140 150
DDVVKPELGS RLDSPRLRIT EAVCKGAVDT AEKLNAPLII VATEAGKSAR
160 170 180 190 200
SVRKYFPTAR ILAVTTNTKT AAQLCLSKGV TPVVVDSIES TDAFYLRGKE
210 220 230
LALETGLGAK GDIVVMVSGA LVASGTTNTA SVHVL
Length:235
Mass (Da):24,734
Last modified:January 1, 1998 - v1
Checksum:iF805606C4C8EF4C1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019143 Genomic DNA. Translation: AAC45776.1.
PIRiPC4418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019143 Genomic DNA. Translation: AAC45776.1 .
PIRi PC4418.

3D structure databases

ProteinModelPortali O30853.
SMRi O30853. Positions 1-235.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 3.20.20.60. 1 hit.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
SSF52935. SSF52935. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The pkI gene encoding pyruvate kinase I links to the luxZ gene which enhances bioluminescence of the lux operon from Photobacterium leiognathi."
    Lin J.-W., Lu H.-C., Chen H.-Y., Weng S.-F.
    Biochem. Biophys. Res. Commun. 239:228-234(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 25521 / L1 / CIP 665.

Entry informationi

Entry nameiKPYK1_PHOLE
AccessioniPrimary (citable) accession number: O30853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3