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Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Enzyme regulationi

Inhibited by hydrogen peroxide.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271ManganeseBy similarity
Metal bindingi82 – 821ManganeseBy similarity
Metal bindingi168 – 1681ManganeseBy similarity
Metal bindingi172 – 1721ManganeseBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-305-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Gene namesi
Name:sodA
Ordered Locus Names:HD_0321
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 213212Superoxide dismutase [Mn]PRO_0000160039Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi233412.HD0321.

Structurei

3D structure databases

ProteinModelPortaliO30826.
SMRiO30826. Positions 2-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0605.
KOiK04564.
OMAiMIMSYTL.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O30826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYQLPELGY AYDALEPYFD KETMEIHHSK HHQAYVNNSN ALLEKHPELL
60 70 80 90 100
EKCPGALLKD LTQVPAEKRT AVRNNLGGHV NHTLFWKGLK TGTTLQGALK
110 120 130 140 150
DAIIRDFGSV EAFQAEFEQA AATRFGSGWA WLVLEEGKLA VVSTANQDSP
160 170 180 190 200
IMGKDVAGVS GYPIFTLDVW EHAYYLHYQN RRPDYIKAFW NVVNWDEASR
210
RFEEKQAGCG CTK
Length:213
Mass (Da):24,107
Last modified:January 23, 2007 - v4
Checksum:i3CE142A1B032E458
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111E → K in AAC46219 (PubMed:9511768).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017750 Genomic DNA. Translation: AAC46219.1.
AE017143 Genomic DNA. Translation: AAP95298.1.
PIRiJC6542.
RefSeqiWP_010944351.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP95298; AAP95298; HD_0321.
KEGGihdu:HD0321.
PATRICi20177209. VBIHaeDuc133973_0263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017750 Genomic DNA. Translation: AAC46219.1.
AE017143 Genomic DNA. Translation: AAP95298.1.
PIRiJC6542.
RefSeqiWP_010944351.1. NC_002940.2.

3D structure databases

ProteinModelPortaliO30826.
SMRiO30826. Positions 2-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi233412.HD0321.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP95298; AAP95298; HD_0321.
KEGGihdu:HD0321.
PATRICi20177209. VBIHaeDuc133973_0263.

Phylogenomic databases

eggNOGiCOG0605.
KOiK04564.
OMAiMIMSYTL.
OrthoDBiEOG63NMNT.

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-305-MONOMER.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sodA gene of Haemophilus ducreyi encodes a hydrogen peroxide-inhibitable superoxide dismutase."
    San Mateo L.R., Toffer K.L., Kawula T.H.
    Gene 207:251-257(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.
  2. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiSODM_HAEDU
AccessioniPrimary (citable) accession number: O30826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.