SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O30725

- HIS4_RHOCB

UniProt

O30725 - HIS4_RHOCB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Gene
hisA, RCAP_rcc01154
Organism
Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81Proton acceptor By similarity
Active sitei129 – 1291Proton donor By similarity

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciRCAP272942:GJIY-1174-MONOMER.
UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
Name:hisA
Ordered Locus Names:RCAP_rcc01154
OrganismiRhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Taxonomic identifieri272942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002361: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2392391-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation
PRO_0000142044Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO30725.

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.

Phylogenomic databases

HOGENOMiHOG000224614.
KOiK01814.
OMAiGWAEETD.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01014. HisA.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00007. TIGR00007. 1 hit.

Sequencei

Sequence statusi: Complete.

O30725-1 [UniParc]FASTAAdd to Basket

« Hide

MILYPAIDLK DGNCVRLLHG EMDKATVFGT DPAAQAAKFE AAGCAWVHLV    50
DLNGAFAGEP VNGAAVEAIL ARITVPAQLG GGIRDMATIE RWLSKGLARV 100
ILGTVAVENP DLVREAAKAF PGQVAVGIDA RNGKVATKGW ATETDVLVTD 150
LAQSFEDAGV AAIIYTDILR DGAMTGPNIE ATEALGRAVT IPVIASGGVS 200
SLPDLIALRD TGVIAGAISG RAIYDGALDL QAALAALKA 239
Length:239
Mass (Da):24,468
Last modified:June 28, 2011 - v2
Checksum:iE5ACBE5A88A1ABCC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101D → N in AAC46106. 1 Publication
Sequence conflicti218 – 2181I → F in AAC46106. 1 Publication
Sequence conflicti223 – 2253IYD → LYN in AAC46106. 1 Publication
Sequence conflicti229 – 2291D → N in AAC46106. 1 Publication
Sequence conflicti235 – 2395AALKA → RP in AAC46106. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016223 Genomic DNA. Translation: AAC46106.1.
CP001312 Genomic DNA. Translation: ADE84912.1.
RefSeqiYP_003577319.1. NC_014034.1.

Genome annotation databases

EnsemblBacteriaiADE84912; ADE84912; RCAP_rcc01154.
GeneIDi9003983.
KEGGircp:RCAP_rcc01154.
PATRICi35502410. VBIRhoCap134200_1175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016223 Genomic DNA. Translation: AAC46106.1 .
CP001312 Genomic DNA. Translation: ADE84912.1 .
RefSeqi YP_003577319.1. NC_014034.1.

3D structure databases

ProteinModelPortali O30725.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE84912 ; ADE84912 ; RCAP_rcc01154 .
GeneIDi 9003983.
KEGGi rcp:RCAP_rcc01154.
PATRICi 35502410. VBIRhoCap134200_1175.

Phylogenomic databases

HOGENOMi HOG000224614.
KOi K01814.
OMAi GWAEETD.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .
BioCyci RCAP272942:GJIY-1174-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01014. HisA.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR00007. TIGR00007. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of Rhodobacter capsulatus mutants affected in cytochrome cbb3 oxidase activity."
    Koch H.G., Hwang O., Daldal F.
    J. Bacteriol. 180:969-978(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MT1131.
  2. "Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003."
    Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., Haselkorn R.
    J. Bacteriol. 192:3545-3546(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-309 / NBRC 16581 / SB1003.

Entry informationi

Entry nameiHIS4_RHOCB
AccessioniPrimary (citable) accession number: O30725
Secondary accession number(s): D5ARP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 28, 2011
Last modified: May 14, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi