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Protein
Submitted name:

Flagellar sensor histidine kinase FleS

Gene

flrB

Organism
Vibrio cholerae
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Flagellar sensor histidine kinase FleSImported (EC:2.7.13.3Imported)
Submitted name:
Histidine kinaseImported
Submitted name:
Sensory box proteinImported
Submitted name:
Two-component sensor kinase proteinImported
Gene namesi
Name:flrBImported
Synonyms:zraS_1Imported, zraS_2Imported, zraS_3Imported
ORF Names:DA89_2415Imported, EN12_10355Imported, ERS013138_02953Imported, ERS013186_02708Imported, ERS013193_03847Imported, ERS013198_00866Imported, ERS013199_02607Imported, ERS013201_02178Imported, ERS013202_02985Imported, ERS013215_02995Imported, ERS013262_04005Imported
OrganismiVibrio choleraeImported
Taxonomic identifieri666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000044349 Componenti: Unassembled WGS sequence
  • UP000043247 Componenti: Unassembled WGS sequence
  • UP000046067 Componenti: Unassembled WGS sequence
  • UP000044626 Componenti: Unassembled WGS sequence
  • UP000045578 Componenti: Unassembled WGS sequence
  • UP000042589 Componenti: Unassembled WGS sequence
  • UP000043560 Componenti: Unassembled WGS sequence
  • UP000043173 Componenti: Unassembled WGS sequence
  • UP000038065 Componenti: Unassembled WGS sequence
  • UP000028652 Componenti: Unassembled WGS sequence
  • UP000036184 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, FlagellumImported

Interactioni

Protein-protein interaction databases

STRINGi345073.VC0395_A1720.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 340209Histidine kinaseInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4105EDZ. Bacteria.
ENOG410XR0Q. LUCA.
KOiK10942.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR000014. PAS.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF13188. PAS_8. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O30663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSSAVQEQH SHLDSLEDQV ERYKQVLDVM PAGVILLDTQ GIVREANPEA
60 70 80 90 100
QRLLDVPLVG EKWYSVIQIA FAPRDDDGHE ISLRNGRKVR LAISASTTGQ
110 120 130 140 150
LILITDLTET RLLQSRISDL QRLSSLGRMV ASLAHQVRTP LSSAMLYAAN
160 170 180 190 200
LAAPNLPPAT RERFQSKLVD RLHDLEKQVN DMLLFAKGGD NKVVMPFSIG
210 220 230 240 250
DLAAEFMPMV ETALKNNQID YGQEVESEET MLLGNANALA SALSNLVMNA
260 270 280 290 300
LQIAGKGSQI DVFFRPVNGE LKISVQDNGP GVPESLQHKI MEPFFTTRSQ
310 320 330 340 350
GTGLGLAVVQ MVCRAHGGRL ELISKEGEGA CFTMCIPLER QADSSNSETG

E
Length:351
Mass (Da):38,379
Last modified:January 1, 1998 - v1
Checksum:i3459AFAEE4ECAF2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014113 Genomic DNA. Translation: AAC46366.1.
CP007653 Genomic DNA. Translation: AKO75632.1.
CWQA01000003 Genomic DNA. Translation: CSB60692.1.
CWPO01000015 Genomic DNA. Translation: CSB65796.1.
CWQJ01000012 Genomic DNA. Translation: CSC25764.1.
CWQG01000015 Genomic DNA. Translation: CSC44144.1.
CWQX01000039 Genomic DNA. Translation: CSC75327.1.
CWPV01000025 Genomic DNA. Translation: CSC78432.1.
CWPL01000463 Genomic DNA. Translation: CSD16752.1.
CWRC01000084 Genomic DNA. Translation: CSD28464.1.
CWSR01000690 Genomic DNA. Translation: CSI51223.1.
JIDQ01000051 Genomic DNA. Translation: KFD80267.1.
PIRiH82114.
RefSeqiWP_001881834.1. NZ_LRIK01000002.1.

Genome annotation databases

EnsemblBacteriaiAKO75632; AKO75632; EN12_10355.
CQB50953; CQB50953; CQB50953.
CRZ49408; CRZ49408; ERS013220_02409.
CRZ72612; CRZ72612; ERS013133_00401.
CSA31831; CSA31831; ERS013164_01244.
CSA47269; CSA47269; ERS013256_00041.
CSB33312; CSB33312; ERS013264_01651.
CSB60692; CSB60692; ERS013198_00866.
CSB65796; CSB65796; ERS013186_02708.
CSB98475; CSB98475; ERS013190_02403.
CSC25764; CSC25764; ERS013201_02178.
CSC29528; CSC29528; ERS013216_01116.
CSC40082; CSC40082; ERS013204_02035.
CSC44144; CSC44144; ERS013202_02985.
CSC75327; CSC75327; ERS013199_02607.
CSC78432; CSC78432; ERS013193_03847.
CSD16752; CSD16752; ERS013262_04005.
CSD28464; CSD28464; ERS013138_02953.
CSI51223; CSI51223; ERS013215_02995.
KFD80267; KFD80267; DA89_2415.
KQA14646; KQA14646; XM60_04305.
KQA33626; KQA33626; XV73_10700.
KQA36502; KQA36502; XV72_03845.
KQA41059; KQA41059; XV74_01725.
KQA45998; KQA45998; XV76_00680.
KQA47755; KQA47755; XV75_02610.
KQA49566; KQA49566; XV77_09955.
KQA54419; KQA54419; XV78_07410.
KQA58450; KQA58450; XV79_05145.
KQA64347; KQA64347; XV80_01745.
KQA66385; KQA66385; XV81_00210.
KQA67024; KQA67024; XV82_12425.
KQA73582; KQA73582; XV83_01735.
KQA75423; KQA75423; XV84_07265.
KQA79753; KQA79753; XV85_05170.
KQA81344; KQA81344; XV86_14010.
KQA86450; KQA86450; XV87_02505.
KQA90576; KQA90576; XV88_04600.
KQA94212; KQA94212; XV89_02790.
KQA96631; KQA96631; XV90_02340.
KEGGivcq:EN18_13755.
PATRICi20083299. VBIVibCho83274_2041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014113 Genomic DNA. Translation: AAC46366.1.
CP007653 Genomic DNA. Translation: AKO75632.1.
CWQA01000003 Genomic DNA. Translation: CSB60692.1.
CWPO01000015 Genomic DNA. Translation: CSB65796.1.
CWQJ01000012 Genomic DNA. Translation: CSC25764.1.
CWQG01000015 Genomic DNA. Translation: CSC44144.1.
CWQX01000039 Genomic DNA. Translation: CSC75327.1.
CWPV01000025 Genomic DNA. Translation: CSC78432.1.
CWPL01000463 Genomic DNA. Translation: CSD16752.1.
CWRC01000084 Genomic DNA. Translation: CSD28464.1.
CWSR01000690 Genomic DNA. Translation: CSI51223.1.
JIDQ01000051 Genomic DNA. Translation: KFD80267.1.
PIRiH82114.
RefSeqiWP_001881834.1. NZ_LRIK01000002.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi345073.VC0395_A1720.

Protocols and materials databases

DNASUi2613272.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAKO75632; AKO75632; EN12_10355.
CQB50953; CQB50953; CQB50953.
CRZ49408; CRZ49408; ERS013220_02409.
CRZ72612; CRZ72612; ERS013133_00401.
CSA31831; CSA31831; ERS013164_01244.
CSA47269; CSA47269; ERS013256_00041.
CSB33312; CSB33312; ERS013264_01651.
CSB60692; CSB60692; ERS013198_00866.
CSB65796; CSB65796; ERS013186_02708.
CSB98475; CSB98475; ERS013190_02403.
CSC25764; CSC25764; ERS013201_02178.
CSC29528; CSC29528; ERS013216_01116.
CSC40082; CSC40082; ERS013204_02035.
CSC44144; CSC44144; ERS013202_02985.
CSC75327; CSC75327; ERS013199_02607.
CSC78432; CSC78432; ERS013193_03847.
CSD16752; CSD16752; ERS013262_04005.
CSD28464; CSD28464; ERS013138_02953.
CSI51223; CSI51223; ERS013215_02995.
KFD80267; KFD80267; DA89_2415.
KQA14646; KQA14646; XM60_04305.
KQA33626; KQA33626; XV73_10700.
KQA36502; KQA36502; XV72_03845.
KQA41059; KQA41059; XV74_01725.
KQA45998; KQA45998; XV76_00680.
KQA47755; KQA47755; XV75_02610.
KQA49566; KQA49566; XV77_09955.
KQA54419; KQA54419; XV78_07410.
KQA58450; KQA58450; XV79_05145.
KQA64347; KQA64347; XV80_01745.
KQA66385; KQA66385; XV81_00210.
KQA67024; KQA67024; XV82_12425.
KQA73582; KQA73582; XV83_01735.
KQA75423; KQA75423; XV84_07265.
KQA79753; KQA79753; XV85_05170.
KQA81344; KQA81344; XV86_14010.
KQA86450; KQA86450; XV87_02505.
KQA90576; KQA90576; XV88_04600.
KQA94212; KQA94212; XV89_02790.
KQA96631; KQA96631; XV90_02340.
KEGGivcq:EN18_13755.
PATRICi20083299. VBIVibCho83274_2041.

Phylogenomic databases

eggNOGiENOG4105EDZ. Bacteria.
ENOG410XR0Q. LUCA.
KOiK10942.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR000014. PAS.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF13188. PAS_8. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Distinct roles of an alternative sigma factor during both free-swimming and colonizing phases of the Vibrio cholerae pathogenic cycle."
    Klose K.E., Mekalanos J.J.
    Mol. Microbiol. 28:501-520(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 0395Imported.
  2. Bishop-Lilly K.A., Johnson S.L., Verratti K., Luu T., Awosika J., Chain P.S., Sozhamannan S.
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 490-93Imported and NIH41Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TSY216Imported.
  4. Informatics Pathogen
    Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 4660Imported, 6196Imported, A217Imported, A232Imported, A325Imported, A346Imported, A346(2)Imported, A483Imported, A487Imported, A487(2)Imported and PRL18Imported.

Entry informationi

Entry nameiO30663_VIBCL
AccessioniPrimary (citable) accession number: O30663
Secondary accession number(s): Q7DCT7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.