O30612 (CLPP2_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit 2
EC=3.4.21.92

Alternative name(s):
Endopeptidase Clp 2

Gene names

Name:	clpP2
Synonyms:	clpP
Ordered Locus Names:	MXAN_6438

Organism

Myxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]

Taxonomic identifier

246197 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus › Myxococcus xanthus

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP-Rule MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP-Rule MF_00444
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S14 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	ATP-dependent Clp protease proteolytic subunit 2 HAMAP-Rule MF_00444		PRO_0000179598
Sites
	Active site	97	1	By similarity
	Active site	122	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O30612 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 6B2A23DE232C46AE	FASTA	203	22,327
	10 20 30 40 50 60 MNVPFVIETT HRGERAYDLY SRLLKDRIIM LGTPVNDDVA NIIVAQLLFL ESEDPDKGIN 70 80 90 100 110 120 LYINSPGGSV TAGLAIYDTM QYVKCPVSTI CVGQAASMGA LLLLAGAKGK RYALPNSRIM 130 140 150 160 170 180 IHQPLGGAQG QATDIDIQAK EILRLRSYIN GLIVKHTGHT IERIEKDTER DYFMSAEDAR 190 200 QYGLIDEVVE KQRVIAPTPA PAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Salmi D., Creighton C., Youderian P. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolution of sensory complexity recorded in a myxobacterial genome." Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J., Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A. , Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B. Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DK 1622.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF013216 Genomic DNA. Translation: AAB97819.1. CP000113 Genomic DNA. Translation: ABF86796.1.
RefSeq	YP_634562.1. NC_008095.1.
3D structure databases
ProteinModelPortal	O30612.
SMR	O30612. Positions 3-189.
ModBase	Search...
Protein-protein interaction databases
STRING	246197.MXAN_6438.
Protein family/group databases
MEROPS	S14.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABF86796; ABF86796; MXAN_6438.
GeneID	4103420.
KEGG	mxa:MXAN_6438.
PATRIC	22655379. VBIMyxXan43560_6333.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0740.
HOGENOM	HOG000285833.
KO	K01358.
OMA	GHTIERI.
ProtClustDB	PRK00277.
Enzyme and pathway databases
BioCyc	MXAN246197:GIWU-6387-MONOMER.
BRENDA	3.4.21.92. 6741.
Family and domain databases
HAMAP	MF_00444. ClpP.
InterPro	IPR001907. ClpP. IPR023562. ClpP/TepA. IPR018215. ClpP_AS. [Graphical view]
PANTHER	PTHR10381. PTHR10381. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
TIGRFAMs	TIGR00493. clpP. 1 hit.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLPP2_MYXXD

Accession

Primary (citable) accession number: O30612
Secondary accession number(s): Q1CYG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program